We report a case of neuromyelitis optica (NMO) with a large cerebral lesion. The patient had an episode of fever and consciousness disturbance with a tumefactive frontal white matter lesion at age 43, and then repeated bilateral optic neuritis and transverse myelitis until she died at age 63. Histopathological examinations revealed that marked tissue destruction, cavities and inflammatory changes typical of NMO were seen in the cerebrum as well as the optic nerves and spinal cord. This is the first autopsied case of NMO with a tumefactive cerebral lesion that later became cavitary.
O’Riordan JI , Gallagher HL , Thompson AJ , Howard RS , Kingsley DP , Thompson EJet al.Clinical, CSF, and MRI findings in Devic’s neuromyelitis optica . J Neurol Neurosurg Psychiatry1996; 60: 382-387 .
3.
de Seze J , Stojkovic T , Ferriby D , Gauvrit JY , Montagne C , Mounier-Vehier Fet al.Devic’s neuromyelitis optica: clinical, laboratory, MRI and outcome profile . J Neurol Sci2002; 197: 57-61 .
4.
Ghezzi A , Bergamaschi R , Martinelli V , Trojano M , Tola MR , Merelli Eet al.Clinical characteristics, course and prognosis of relapsing Devic’s neuromyelitis optica . J Neurol2004; 251: 47-52 .
5.
Mandler RN , Davis LE , Jeffery DR , Kornfeld M.Devic’s neuromyelitis optica: a clinicopathological study of 8 patients . Ann Neurol1993; 34: 162-168 .
6.
Lucchinetti CF , Mandler RN , McGavern D , Bruck W , Gleich G , Ransohoff RMet al.A role of humoral mechanism in the pathogenesis of Devic’s neuromyelitis optica . Brain2002; 125: 1450-1461 .
Scott TF , Bhagavatula K , Snyder PJ , Chieffe C.Transverse myelitis. Comparison with spinal cord presentations of multiple sclerosis . Neurology1998; 50: 429-433 .
9.
Fukazawa T , Kikuchi S , Niino M , Yabe I , Hamada T , Tashiro K.Multiphasic demyelinating disorder with acute transverse myelitis in Japanese . J Neurol2003; 250: 624-626 .
10.
Misu T , Fujihara K , Nakashima I , Miyazawa I , Okita N , Takase Set al.Pure optic-spinal form of multiple sclerosis in Japan . Brain2002; 125: 2460-2468 .
