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Abstract

Experimental autoimmune encephalomyelitis (EAE) was found to have a chronic and significantly worse course in apolipoprotein-E (apoE) deficient female mice when compared with matched controls. Disease measures compared included incidence of EAE (64% versus 31%, P <0.05, x² test), maximal clinical score (average ±SD 2.81±2.5 versus 0.75±1.1, P <0.01, Mann -Whitney test) and mortality (27.3% versus 0%, P =0.02, Mann -Whitney test and x² test). A poE deficient mice had significantly increased lymphocyte proliferation responses to both myelin antigens and mitogens and significantly more infiltrating lesions in the central nervous system (CNS) in histopatho logy. Defective neuronal repair mechanisms and enhanced immune reactivity in apoE deficient mice may explain our findings. C linical implications for MS are discussed.

Keywords

A lzheimer’s disease apoE experimental autoimmune encephalomyelitis (EA E)multiple sclerosis

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Lack of apolipoprotein-E exacerbates experimental allergic encephalomyelitis

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