Abstract
We report the case of a woman who developed subacute cutaneous lupus erythematosus (SCLE) after exposure to the sun while taking cinnarizine and thiethylperazine. The patient recalled that 10 years previously, a similar eruption had appeared after sunbathing, while she was taking only cinnarizine. SCLE development in this patient was probably drug related and there is some evidence that cinnarizine played an important pathogenic role.
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References
1.
Sontheimer RD
. Subacute cutaneous lupus erythematosus: a decade's perspective . Med Clin North America
1989 ; 73 : 1073 –1090 .
2.
Sontheimer RD
et al. Serologic and HLA associations in subacute cutaneous lupus erythematosus . Ann Intern Med
1982 ; 97 : 664 –671 .
3.
Bielsa I
et al. Immunogenetic findings in cutaneous lupus erythematosus . J Am Acad Dermatol
1991 ; 25 : 251 –257 .
4.
Callen JP
,
Kulick KB
,
Stelzer G
,
Fowler JF
. Subacute cutaneous lupus erythematosus. Clinical, serologic and immunogenetic studies of forty-nine patients seen in nonreferral setting . J Am Acad Dermatol
1986 ; 15 : 1227 –1237 .
5.
Norris D
. Pathomechanisms of photosensitive lupus erythematosus . J Invest Dermatol
1993 ; 100 : 58S –68S .
6.
Sontheimer RD
,
Provost TT
. Cutaneous manifestations of lupus erythematosus . In: Dubois' lupus erythematosus .
Wallace DJ
and
Hahn BH
(eds). Williams & Wilkins : Baltimore , 1997 , pp 569 –623 .
7.
Sontheimer RD
. Photoimmunology of lupus erythematosus and dermatomyositis: a speculative review . Photochem Photobiol
1996 ; 63 : 583 –594 .
8.
Lee LA
et al. The autoantibody response to Ro/SS-A autoantibodyassociated cutaneous lupus erythematosus . Dermatologic Clinics
1990 ; 8 : 751 –758 .
9.
Norris DA
. Pathomechanisms of photosensitive lupus erythematosus . J Invest Dermatol
1993 ; 100 : 585 –685 .
10.
Harber LC
,
Baer RL
. Pathogenic mechanisms of drug-induced photosensitivity . J Invest Dermatol
1972 ; 58 : 327 –342 .
11.
Allen J
. Drug-induced photosensitivity . Clin Pharm
1993 ; 12 : 580 –587 .
12.
Miyagawa S
et al. Lichen planus pemphigoides-like lesions induced by cinnarizine . Br J Dermatol
1985 ; 122 : 607 –613 .