The introduction of blood cardioplegia has been proven to limit ischaemia and
reperfusion injury in cardiac surgery. But the presence of activated neutrophils
in the capillary bed may cause further damage. Leukocyte filters have been shown
to be very effective in reducing the leukocytes in blood cardioplegia to less
than 10%. Leukocyte depletion of blood cardioplegia provides an excellent
approach to minimizing myocardial injury, predominantly in high-risk cardiac surgery.
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