Abstract
Trisomy 22 (47, XX, +22), a rare chromosomal defect, was detected antenatally by chromosome analysis of the amniotic fluid after an obstetric ultrasound examination revealed multiple anomalies. The ultrasound findings included intrauterine growth retardation, holoprosencephaly, cleft lip, cardiac anomalies, decreased amniotic fluid level, and an abnormally thickened nuchal fold. Postnatal examination and autopsy confirmed the ultrasound findings.
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