A 2-year-old male presented with fever, rash, right upper quadrant pain, and hyperbilirubinemia and was diagnosed with Langerhans cell histiocytosis (LCH). Periportal, hepatic, pulmonary, thymic, and thyroid involvement was noted on initial imaging. Thyroid gland involvement by LCH is rare. This case illustrates computed tomography, ultrasonography, and magnetic resonance imaging features of LCH of the thyroid.
Behrens RJ, Levi AW, Westra WH, Dutta D., Cooper DS: Langerhan's histiocytosis of the thyroid: a report and review of the literature . Thyroid2001;11:697-705.
Weitzman S., Egeler R.: Langerhans cell histiocytosi: update for the pediatrician. Curr Opin Pediatr2008;20: 23-29.
4.
Chu T., D'Angio GJ, Favara BE, et al. Histiocytosis syndromes in children. Lancet1987;2:41-42.
5.
Schmidt S., Eich G., Geoffray A., et al: Extraosseous involvement of Langerhan's cell histiocytosis in children. Ped Radiol2004;34:313-322.
6.
Junewick JJ, Fitzgerald NE: The thymus in Langerhans cell histiocytosis. Ped Radiol1999;29:904-907.
7.
Azouz EM, Saigal G., Rodriguez MM, Podda A.: Langerhans' cell histiocytosis: pathology, imaging, and treatment of skeletal involvement. Ped Radiol2005;35: 103-115.
8.
Maurea S., Lastoria S., Klain M., et al: Evaluation of thyroid involvement by histiocytosis X. J Nucl Med1994;35: 263-265.
9.
Giovanella L. , Ceriani L., Crippa S., Mazzucchelli L.: Image in endocrinology: Langerhans cell histiocytosis of the thyroid gland detected by 18FDG-PET/CT. J Endocrinol Metab2007;92:2866-2867.
10.
Braiteh F., Kuzrock R.: Langerhans cell histiocytosis of the thyroid. J Clin Onocol2006;24:522-523.
11.
Lollar K., Farraq TY, Cao D., Niparko J., Tufano RP: Langerhans cell histiocytosis of the thyroid gland. Am J Otolaryngol2008;29:201-204.
