Variability of Serum Theophylline Concentrations in Outpatient Asthmatic Children

Kelly WH Murphy S . Should we stop using theophylline for the treatment of the hospitalized patient with status asthmaticus? DICP Ann Pharmacother 1989; 23: 995–8.

Fairshter RD Busse WW . Theophylline—how much is enough? J Allergy Clin Immunol 1986; 77: 646–8.

Neijens HJ Duiverman EJ Graatsma BH Kerrebijn KF . Clinical and bronchodilating efficacy of controlled-release theophylline as a function of its serum concentrations in preschool children. J Pediatr 1985; 107: 811–5.

Simons ER Luciuk GH Simons KJ . Sustained-release theophylline for treatment of asthma in preschool children. Am J Dis Child 1982; 136: 790–3.

Levy G Koysooko R . Pharmacokinetic analysis of the effect of theophylline on pulmonary function in asthmatic children. J Pediatr 1975; 86: 789–93.

Polluck J Kiechel F Cooper D Weinberger M . Relationship of serum theophylline concentration to inhibition of exercise-induced bronchospasm and comparison with cromolyn. Pediatrics 1977; 60: 840–4.

Weinberger M Hendeles L . Slow-release theophylline rationale and basis for product selection. N Engl J Med 1983; 308: 760–4.

Milavetz G Vaughan LM Weinberger MM Hendeles L . Evaluation of a scheme for establishing and maintaining dosage of theophylline in ambulatory patients with chronic asthma. J Pediatr 1986; 109: 351–4.

Ekwo E Weinberger M . Evaluation of a program for the pharmacologic management of children with asthma. J Allergy Clin Immunol 1978; 61: 240–7.

Wilkinson L . Systat: The system for statistics. Evanston, IL: Systat, 1986.

Menendez R Kelly WH Howick J McWilliams BC . Sustained-release theophylline: Pharmacokinetic and therapeutic comparison of two preparations. Am J Dis Child 1983; 137: 469–73.

Weinberger M Hendeles L Wong L Vaughan L . Relationship of formulation and dosing interval to fluctuation of serum theophylline concentration in children with chronic asthma. J Pediatr 1981; 99: 145–52.

Haltom JR Szefler SJ . Theophylline absorption in young asthmatic children receiving sustained-release formulations. J Pediatr 1985; 107: 805–10.

Kolski GB Levy J Anolik R . The use of theophylline clearance in pediatric status asthmaticus. Am J Dis Child 1987; 141: 282–7.

Wyatt R Weinberger M Hendeles L . Oral theophylline dosage for the management of chronic asthma. J Pediatr 1978; 92: 125–30.

Ginchansky E Weinberger M . Relationship of theophylline clearance to oral dosage in children with chronic asthma. J Pediatr 1977; 91: 655–60.

Table D . 10: Critical values of the T distribution. In: Zar JH , ed. Biostatistical analysis. Englewood Cliffs, NJ: Prentice-Hall, 1974: 413–4.

Loren M Miklich DR Chai H Barwise G . Aminophylline bioavailability and the across-time stability of plasma theophylline levels. J Pediatr 1977; 90: 473–6.

Cheung CM Soldin S . Clinical evaluation of a dry chemistry strip theophylline assay. Ther Drug Monit 1986; 8: 205–10, 215.

Hill M Hendeles L . Evaluation of an office method of measuring theophylline serum concentrations. J Allergy Clin Immunol 1988; 82: 30–4.

Pollack GM Baswell B Szefler SJ Shen DD . Comparison of inter- and intra-subject variation in oral absorption of theophylline from sustained-release products. Int J Pharmaceut 1984; 21: 3–16.

Dederich RA Szefler SJ Green ER . Intrasubject variation in sustained-release theophylline absorption. J Allergy Clin Immunol 1981; 67: 465–71.

Leung P Kalisker A Thomas DB . Variation in theophylline clearance rate with time in chronic childhood asthma. J Allergy Clin Immunol 1977; 59: 440–4.

Walson PD Strunk RC Taussig LM . Intrapatient variability in theophylline kinetics. J Pediatr 1977; 91: 321–4.

Slaughter RL . Theophylline commentary. In: Evans WE Schentag JJ Jusko WJ , eds. Applied pharmacokinetics: Principles of therapeutic drug monitoring. Spokane, WA: Applied Therapeutics, 1986: 1189–209.

Weinstein AG Cuskey W . Theophylline compliance in asthmatic children. Ann Allergy 1985; 54: 19–24.

Wood PR Casey R Kolski GB McCormick MC . Compliance with oral theophylline therapy in asthmatic children. Ann Allergy 1985; 54: 400–4.

Eney RD Goldstein EO . Compliance of chronic asthmatics with oral administration of theophylline measured by serum and salivary levels. Pediatrics 1976; 57: 513–7.

Cramer JA Mattson RH Prevey ML Scheyer RD Ouellette VL . How often is medication taken as prescribed? A novel assessment technique. JAMA 1989; 261: 3273–7.