Abstract
Background:
Acute sleep deprivation impairs cognitive, psychomotor, and mood outcomes, in part by reducing cerebral adenosine triphosphate (ATP) availability. Creatine supplementation may counter these effects by increasing phosphocreatine stores.
Methods:
Six databases were systematically searched (January 2006–May 2025) for studies investigating creatine’s effects on cognitive, psychomotor, and mood outcomes during acute sleep deprivation.
Results:
Results were synthesized narratively. Of 160 records, five studies met the inclusion criteria. Early investigations indicate a positive trend for creatine supplementation as an intervention for acute sleep deprivation, though effects may vary by cognitive domain.
Conclusion:
Despite favorable early results, research is sparse, and future high-quality trials are needed.
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