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Abstract

Background:

Chiropractors commonly manage cervicogenic headache (CGH) and tension-type headache (TTH) using nonpharmacological interventions such as spinal manipulative therapy. However, dedicated guidelines on chiropractic management of headaches are outdated.

Methods:

We first conducted an umbrella review. A search for systematic reviews and clinical practice guidelines on nonpharmacological interventions for adults with CGH or TTH published from 2017 to August 2023 was conducted. At least two authors independently performed article screening, risk of bias/quality assessment, certainty of evidence, and data extraction. A steering committee developed statements from the synthesized data and seed documents, which were refined by anonymous feedback from a 57-member Delphi panel until reaching at least 80% consensus. The statements were then subjected to public comment, prompting further revisions that were subsequently reviewed by the Delphi panel.

Results:

Thirty-two relevant articles were identified (31 systematic reviews and 1 clinical practice guideline). Statements included recommendations regarding history (e.g., red flags) and examination for CGH/TTH, recommendation to use of spinal manipulation for CGH, and for TTH only within multimodal care. Certainty of evidence and strength of recommendations for other nonpharmacological interventions (e.g., acupuncture and exercise) varied. Limitations in evidence precluded strong recommendations for acupuncture, education, meditation/mindfulness, and modalities used in isolation for CGH and electroacupuncture for TTH.

Conclusions:

This clinical practice guideline created evidence-based consensus recommendations for chiropractic management of adults with CGH and TTH. Chiropractors may appropriately care for individuals with CGH and TTH using a variety of nonpharmacological interventions, while considering best practices in diagnosis, referral, and other aspects of care management.

Keywords

acupuncture chiropractic exercise therapy headache practice guidelines spinal manipulation

Background

Tension-type headache (TTH) is a common primary headache disorder with a prevalence of 26% in adults worldwide.¹ Manifesting as a pressing or tightening sensation with referred head pain, TTH affects the muscles around the head and neck. Cervicogenic headache (CGH) is a secondary headache arising from a disorder of the cervical spine,² with a variably reported prevalence ranging from 0.2% in individuals aged 30–44³ to 4.1% in those aged 18–65.⁴ CGH arises from cervical structures including facet joints, intervertebral discs, and/or soft tissues,⁵ whereas TTH is multifactorial, with potential sources including genetic predisposition and peripheral and central sensitization.^6–8

Chiropractors are conservative care clinicians who commonly treat patients with musculoskeletal disorders including spinal pain and headache.^9,10 Headache is one of the most common reasons that patients present to chiropractors, occurring in about 6% of their patients.^9,10 Furthermore, chiropractors are the most commonly sought first provider for the management of new-onset neck pain.¹¹ The most frequent treatment chiropractors use for headache is spinal manipulative therapy, defined herein as a high-velocity, low-amplitude thrust applied to the spinal joints.¹² While spinal manipulative therapy accounts for approximately 79% of chiropractor-delivered treatments, chiropractors may use a broad range of other nonpharmacological treatments.⁹ These include soft tissue therapy, spinal mobilization, acupuncture, transcutaneous electrical nerve stimulation, therapeutic exercises, nutritional supplements, and patient education.^9,13

Although TTH and CGH have different etiologies, neck pain and dysfunction are common in both.^14,15 Neck pain affects 92% of those with CGH¹⁶ and 88% of those with TTH.¹⁷ Cervical spine-related symptoms including tenderness and limited range of motion are often present in both CGH and TTH.^14,15,18 A key distinction is that neck symptoms in TTH are not intrinsic in causing the headache.¹⁸ Despite being classified differently, with TTH as a primary headache and CGH as a secondary headache arising from cervical spine disorders, both conditions frequently involve neck pain and dysfunction.^14,15 Patients often seek chiropractic spinal manipulative therapy to address neck pain and/or headache,^9,10 possibly due to its potential to alleviate associated muscle tension or cervical dysfunction. Recent U.S. survey data further highlight this observation, indicating that chiropractors encounter neck pain and headache in 81% and 66% of their patients on a daily basis, respectively.¹⁹ However, the biomechanical or neurophysiological mechanisms of spinal manipulative therapy remain unclear,²⁰ and the evidence supporting the use of this therapy for TTH and CGH requires an update and re-appraisal.

Nonopioid analgesics (e.g., acetaminophen) and nonsteroidal anti-inflammatory drugs (e.g., ibuprofen) are common first-line treatments for CGH and TTH,^6,21 although there is little evidence supporting acetaminophen for pain relief.^22,23 Other medications with a greater potential for dependency and medication overuse headache, for example, opioids and butalbital, are also commonly used.^16,17,24 Some headache sufferers prefer to avoid pharmacological regimens altogether.²⁵ According to the 2012 United States National Health Interview Survey, spinal manipulative therapy was one of the most commonly used complementary and integrative health approaches for headaches, being used in 22% of those with headache or migraine.²⁶ Patients also were reported to use herbs and supplements and engage in movement therapies, among other nonpharmacological interventions.²⁶

The most recent clinical practice guidelines for chiropractic management of adults with headaches were published in 2011 and 2019,^27,28 with the latter representing a broader guideline focusing on nonpharmacological care for headaches associated with neck pain. Both guidelines concluded that spinal manipulative therapy was beneficial for CGH, yet evidence was limited supporting its efficacy for TTH.^27,28 In addition, these guidelines did not address the use of dry needling, another treatment used by chiropractors.^27,28 Therefore, updated clinical practice guidelines are needed to capture potential growth in the literature while considering a broader range of therapies used by chiropractors for headache.

In addition to therapeutic interventions, effective management of CGH and TTH depends on accurate diagnosis, which is informed by thorough history taking and physical examination. Considering chiropractors are often first-contact providers for patients with neck pain and headache,^9–11 they must be able to distinguish between headache types, identify red or orange flags suggestive of serious pathology, and recognize yellow flags that may influence treatment response.^29–31 Accordingly, an updated, broad-scope review and guideline addressing these diagnostic and assessment elements may support appropriate decision-making regarding care planning and referral.

For this clinical practice guideline, we define nonpharmacological care as interventions that do not involve the use of medications, injections, or surgeries. This category includes, but is not limited to, manual therapies (such as spinal manipulative therapy, joint mobilization, and soft tissue manipulation), exercise, education, mind–body interventions (e.g., mindfulness, yoga), acupuncture, dry needling, and physical modalities (e.g., electrotherapy, heat, or cold therapy). This definition is informed by a previous review of nonpharmacological therapies for chronic pain³² and interventions that may be used or considered in chiropractic practice.^9,10,33

Although chiropractors are the most frequent providers of spinal manipulative therapy in the United States and use a range of nonpharmacological therapies sought by those with headache, there are no recent, comprehensive clinical practice guidelines addressing the use of these therapies by chiropractors.

The primary aim of this project was to evaluate the effectiveness of nonpharmacological interventions for adults with CGH or TTH and to use this evidence to inform the development of a clinical practice guideline for chiropractors. Specific objectives included: (1) identifying and appraising existing systematic reviews and clinical practice guidelines relevant to chiropractor-delivered care for CGH and TTH; (2) synthesizing evidence related to diagnosis, history taking, physical examination, imaging, care management, and nonpharmacological treatments related to care delivered by chiropractors, and (3) formulating evidence-based recommendations for both clinical decision-making and treatment through a Delphi process. The resulting guideline addresses nonpharmacological chiropractic management of adults with CGH or TTH, including examination, clinical decision-making, and treatment. The intended impact is to support improvements in pain, headache frequency, disability, and quality of life for adults affected by TTH and/or CGH.

Methods

This clinical practice guideline provides evidence-based recommendations for chiropractic management of adults with TTH or CGH using nonpharmacological interventions, covering aspects of diagnosis, examination, imaging, and care management. The target audience is chiropractors, with the goal of improving pain, frequency, disability, and quality of life for patients with TTH or CGH.

We followed the Preferred Reporting Items for Systematic reviews and Meta-Analyses when reporting the review and the Appraisal of Guidelines for Research and Evaluation for the clinical practice guideline (Supplementary Data S2, Supplementary Table S1).³⁴ Checklists detailing our adherence to these frameworks appear in Supplementary Data S4 and Supplementary Data S5. We adhered to a registered protocol (International Prospective Register of Systematic Reviews #CRD42023461883).

The Institutional Review Board of Texas Chiropractic College approved the project prior to the Delphi panel formation. Delphi panelists signed a consent form affirming their participation was voluntary and without compensation.

Steering committee

The steering committee performed the main project functions of identifying, assessing, and synthesizing the evidence; developing evidence-based recommendations; and integrating the Delphi panel and public comments into the recommendations. The steering was composed of 12 members: 10 doctors of chiropractic, 1 medical physician, a neurologist specializing in headaches, and 1 health sciences librarian. Their mean years of professional experience were 20 (min–max: 5–38). Four were health professions faculty (three chiropractic and one medical), one was a postdoctoral trainee as well as practicing doctor of chiropractic, and the rest were in full-time practice, four of which were interdisciplinary practices. All have been involved in research as investigators, and nine had previously participated in developing clinical practice guidelines.

Seed documents

The steering committee identified documents providing background information regarding the current evidence for interventions, especially nonpharmacological interventions for CGH and TTH. These also aided in developing the literature search parameters and clinical practice guideline structure.^{27,28,32,35–38}

Literature search

To provide a foundation for clinical practice guideline development, we performed a comprehensive literature search. Our research question was: Which nonpharmacological interventions for adults with CGH or TTH are effective? We focused on nonpharmacological interventions because the chiropractic scope of practice does not typically include medications or surgery. In addition, the steering committee was provided with lists of included and excluded articles and was asked to contribute additional references.

To answer the research question, we formulated elements defining the population, interventions, comparisons, and outcomes as follows:

Population: Adults (age ≥18) with CGH or TTH.

Interventions: Nonpharmacological interventions (e.g., spinal manipulative therapy, manual therapy and soft tissue manipulation, education, exercise, mind–body interventions, acupuncture, dry needling, and modalities such as electrotherapy, heat, or cold).

Comparisons: Any comparison, no restrictions.

Outcomes: Improvement in headache outcomes, including pain intensity, frequency and duration, function, and quality of life.

Our search strategy was developed by a research librarian (SW) alongside several coauthors (CH, DT, KA, and RT). We conducted initial test searches in PubMed, refining our query by adding and removing terms. The librarian translated our research question into search concepts, using filters for date, language, and publication type reflecting the above-stated elements and eligibility criteria. The librarian then adapted the PubMed query for other databases, including the Cochrane Database of Systematic Reviews and Cumulative Index of Nursing and Allied Health Literature, with all searches conducted in August 2023. The complete search strategies are available in Supplementary Data S1. Additional articles were sought via reference tracking and consulting experts in the field.

In addition to the primary literature search focused on nonpharmacological treatments, the steering committee conducted targeted searches to support sections of the guideline related to history taking, physical examination, and clinical decision-making. These searches and corresponding article selection relied upon section-specific eligibility criteria without limitations by study type, corresponding to their subject focus in the guideline rather than requiring solely systematic reviews or clinical practice guidelines of randomized controlled trials. These searches included queries of PubMed and Google Scholar, citation tracking of seed documents,^{27,28,32,35–38} and the inclusion of key references suggested by the steering committee based on previous clinical, guideline, and research experience. Further targeted searches were conducted in response to the Delphi process and public comments.

Eligibility criteria

Inclusion criteria

Published in peer-reviewed journal from 1/01/2017 through 8/24/2023. This start date precedes the end dates two seed document searches; a systematic review covering nonpharmacological treatments for chronic TTH³² and clinical practice guideline.²⁸

English language.

Study population comprised of adults treated for CGH or TTH.

Study intervention(s) included at least one nonpharmacological therapy.

Publication types including clinical practice guidelines and systematic reviews and meta-analyses of randomized controlled trials, or a combination of randomized and nonrandomized studies of interventions.

Exclusion criteria

Reviews, commentaries, abstracts from conference proceedings, theses, cross-sectional descriptive surveys, observational studies, and gray literature. These were excluded due to being considered lower quality evidence.

Articles addressing only migraine or other headache types and not CGH or TTH.

Articles only addressing acute or post-traumatic headache.

Articles that did not include nonpharmacological interventions.

Articles not providing separate analyses of CGH or TTH.

Screening

Search results were screened in duplicate (C.H. and R.J.T.), first by title/abstract, and then by full text. Disagreements regarding eligibility were resolved by discussion.

Evaluation of article quality

We evaluated the quality of articles meeting inclusion criteria. We used the Appraisal of Guidelines for Research and Evaluation instrument Global Rating Scale to assess clinical practice guidelines³⁴ and the Scottish Intercollegiate Guideline Network checklist for systematic reviews and meta-analyses (Supplementary Data S2, Tables S1 and S2, respectively).³⁹ At least two investigators rated each study and discussed differences in ratings until they reached agreement. Scottish Intercollegiate Guidelines Network scores were graded using threshold of high quality, low risk of bias (score of 10–12; majority of “yes” responses), acceptable quality, low risk of bias (7–9), low quality, high risk of bias (4–6), or unacceptable/reject (0–3). In this model, no items were assigned a higher weight than others. Appraisal of Guidelines for Research and Evaluation followed a similar threshold-driven approach with the maximum scores of 6 and 7 based on the main component items, with a determination that allowed raters to weigh the various factors.

Evaluation of evidence certainty

To evaluate the overall level of evidence for interventions, we adapted the Grading of Recommendations Assessment, Development, and Evaluation approach to account for the synthesis of systematic reviews rather than individual randomized controlled trials (Supplementary Data S2, Supplementary Table S3).^40–42 Initial determinants of our initial certainty ratings were article quality ratings from the Scottish Intercollegiate Guideline Network ratings (which incorporate risk of bias and publication bias) and Appraisal of Guidelines for Research and Evaluation ratings, and the number and consistency of studies contributing to each rating for each intervention. We secondarily considered Grading of Recommendations Assessment, Development, and Evaluation domains of imprecision, inconsistency, and indirectness to determine if additional downgrading was necessary. Each rating was derived de novo, rather than relying on the cited study authors’ own ratings. Finally, we incorporated article quality/risk-of-bias assessments of randomized controlled trials as provided within our synthesized articles, rather than replicating these de novo, which would have been impractical for a large number of studies and cited trials. These quality scores were pragmatically categorized as high, acceptable, low, or very low. When available, pooled estimates from meta-analyses (versus narrative syntheses) and recent publications (versus older) were prioritized when deriving evidence certainty scores per condition and outcome, which enabled better assessments of precision and more updated data, respectively. At least two investigators independently performed evidence certainty assessments, with discrepancies resolved via discussion (performed by C.H., R.J.T., and C.J.D.).

After the quality assessment was completed, the steering committee was provided with all included articles and quality assessments.

Data extraction

Tables were constructed with the key characteristics of included study. Extracted items were determined a priori, including publication date, number of studies included, article quality, total number of patients, interventions, and summary of outcomes. To determine treatment effectiveness, data extractors considered effect estimates and measures of precision and statistical significance from synthesized studies, reviewing forest plots and subgroup analyses when available and appropriate. We avoided relying on authors’ broader conclusions that may have been oversimplified or not directly applicable to our research questions. One investigator (C.H.) extracted data and at least one other investigator (R.J.T., M.R.P., D.N.T., and C.J.D.) verified it, discussing disagreements until they were resolved. Completed data tables were provided to the steering committee to consider when making the clinical practice guideline recommendations.

Development of seed statements

The steering committee first agreed on domains to be covered in the clinical practice guideline, deciding the structure would follow the order of the clinical encounter. The initial proposed structure was adapted from a prior chiropractic clinical practice guidelines.^35,43,44 Other seed documents played a role in helping structure material related to diagnosis, clinical decision-making, and red/orange flags including The International Classification of Headache Disorders, 3rd edition,³⁶ an overview of clinical practice guidelines for musculoskeletal pain,³⁷ and a primary care resource from the European Headache Federation and Global Campaign against Headache.³⁸ Steering committee members then developed statements addressing key aspects within each domain. Domains for both CGH and TTH included informed consent; history, physical examination and special tests; diagnosis; patient-reported outcome measures; frequency and duration of treatment; follow-up/re-evaluation; and concurrent care and co-management and/or referral. Interventions were addressed separately for each type of headache. Steering committee members drafted and revised content for specific domains iteratively, reaching consensus over several rounds of internal review. Each set of statements included supporting citations, with a reference list accessible to Delphi panelists during the consensus process to facilitate evidence-informed ratings.

Delphi consensus panel

We identified a list of possible candidates to form a panel of Doctors of Chiropractic and other health professionals with experience in managing headaches and who also valued scientific evidence. We estimated a panel of approximately 50–60 members would provide an appropriate range of viewpoints, based on our previous Delphi projects. We aimed for the majority to be doctors of chiropractic, given the goal of developing profession-specific recommendations. However, we also sought to include medical physicians, particularly headache specialists. We attempted to ensure geographical and ethnic diversity among the panelists. We identified candidates by (1) consulting lists of previous Delphi panelists for chiropractic clinical practice guidelines^35,43–45 and (2) inviting nominees and volunteers among the Clinical Compass board, which includes representatives of ChiroCongress, the American Chiropractic Association, the American Black Chiropractic Association, and the Association of Chiropractic Colleges. We limited panelist selection to practitioners based in the United States, as clinical recommendations may vary due to differences in international regulatory environments. We asked volunteers and nominees to submit a form describing their practice characteristics and their curriculum vitae. These materials were reviewed by the steering committee to guide panelist selection. We aimed to include practitioners with a range of years in practice to capture a diversity of perspectives. Selection prioritized individuals with previous experience in guideline development, additional academic degrees or certifications (e.g., diplomate status), interdisciplinary practice experience, and/or involvement in research or professional education. Final panelist selection was based on group discussion and consensus among the steering committee.

Methodology of the modified Delphi process

In attempt to reduce bias, panelists were anonymous during the consensus process, being identified by a number only, which only the project director (C.H.) and project coordinator (CE) knew. This was done because all raters’ comments were shared among the SC and the Delphi panelists. We used an established systematic and quantitative methodology of incorporating evidence and expert opinion to reach group consensus.⁴⁶ Panelists used a 9-point ordinal Likert “appropriateness” rating scale for each seed statement. “Appropriate” means that the expected patient health benefits exceed expected negative effects by a large enough margin that the recommended action is worthwhile, without considering costs.⁴⁶ The scale is anchored by “highly inappropriate” (1) and “highly appropriate (9), with “uncertain” placed over the middle of the scale. Unlimited space was provided for comments after every statement. We asked that panelists provide supporting citations when disagreeing with recommendations. In addition to the reference list they received accompanying the rating statements, we offered to email panelists a bibliographic file of all citations to aid in their deliberations.

Data management and analysis

The project coordinator entered rating scores into a Statistical Product and Service Solutions (version 25, IBM Corp., Armonk, NY, US) database. Medians and percentages of agreement were calculated for each statement. To be congruent with the methodology, we required an a priori of at least 80% agreement with a median rating of at least 7 to be considered consensus.^46,47 The project coordinator pasted panelists’ comments into a Microsoft Word® table, organized by panelist identification number, statement number, and rating. The steering committee examined the ratings and their associated deidentified comments. Balancing the comments with all supporting evidence, the steering committee revised statements that did not reach 80% agreement. Revised statements were returned to the Delphi panel, with their deidentified comments, for another round of rating.

External review: public comments

Multiple methods of dissemination are recommended by organizations such as Appraisal of Guidelines, Research and Evaluation for ensuring stakeholder involvement in clinical practice guideline development.³⁴ We included stakeholders from the inception of the project by representing chiropractic organizations on the steering committee and Delphi panel. These included representatives of US’ state chiropractic associations, faculty from health professions institutions, practitioners of other health professions such as medicine, nursing, physical therapy, or massage therapy, and interested laypeople such as vendors. After achieving consensus on the recommendations in the modified Delphi process, we solicited public comments on the draft clinical practice guideline, using several methods:

A MailChimp (Atlanta, GA, US) email blast to the Clinical Compass contact list, which included the Clinical Compass Board (including United States’ state and national chiropractic organizations, academic institutions, vendors, and interested laypersons [∼900 individuals]).

Direct invitations through the chiropractic organization ChiroCongress to its member associations (∼35,000 chiropractors).

Postings on Facebook (Meta Platforms, Inc., CA, US) and LinkedIn (Microsoft, WA, US) via the Clinical Compass page, which is available to health professionals and interested laypersons. Social media posts were publicly visible and actively shared to a broader audience.

Notification to the Chiropractic Summit, a national organization of various chiropractic groups and interested individuals.

Using multiple methods with some overlap served to reinforce the message, as did a follow-up mailing 2 weeks later. The comment period was 30 days.

The Clinical Compass website (https://clinicalcompass.org/) provided links to several portable document files: a request for input; summary of methods; and the draft recommendations accompanied by the reference list. We also posted a fillable comment form to facilitate response. The project coordinator collected the comments and entered them into a Microsoft Word® table. The steering committee read all comments and considered revisions as appropriate. If a comment resulted in requiring a substantive change, the revised statements would be recirculated to the Delphi panel to reach consensus.

Results

Literature search

The search yielded 204 citations; 1 additional citation was added from expert consultation and reference tracking, for a total of 205 (see Fig. 1 for study selection flowchart). After removing duplicates, 179 citations remained. A total of 137 citations were excluded; reasons for exclusion are categorized in Figure 1 and detailed in Supplementary Data S3. This left 32 articles to be included in the evidence synthesis: 31^32,48–77 were systematic reviews/meta-analyses and 1 was a clinical practice guideline (Table 1).²⁸

FIG. 1.

Article selection flow diagram (Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020). CINAHL, Cumulative Index to Nursing and Allied Health Literature; HA, headache.

Table 1.

Included Studies by Headache Type and Study Design

Quality^a	Design^b	1^st author	Year	Headache type^c
A	SR	Aslıyüce⁴⁸	2022	CGH
A	SR	Becher⁴⁹	2023	CGH
H	MA	Bini⁵⁰	2022	CGH
A	SR	Cardoso⁵¹	2022	CGH
A	MA	Demont⁵²	2023	CGH
H	MA	Fernandez⁵³	2020	CGH
A	SR	Núñez‐Cabaleiro⁵⁴	2022	CGH
A	MA	Coelho⁵⁵	2019	CGH/TTH
H	CPG	Côté²⁸	2019	CGH/TTH
A	SR	Vázquez-Justes⁵⁶	2022	CGH/TTH
A	SR	Machado-Oliveira⁵⁷	2020	CGH/TTH
H	MA	Pourahmadi⁵⁸	2021	CGH/TTH
H	MA	(Rehman) Aemaz⁵⁹	2022	TTH
H	MA	Anheyer⁶¹	2019	TTH
H	MA	Anheyer⁶⁰	2020	TTH
A	SR	Cumplido-Trasmonte⁶²	2021	TTH
H	MA	Falsiroli Maistrello⁶³	2018	TTH
H	MA	Fan⁶⁴	2021	TTH
A	MA	Hall⁶⁵	2017	TTH
H	MA	Hu⁶⁶	2023	TTH
H	SR	Huang⁶⁷	2020	TTH
H	MA	Jiang⁶⁸	2019	TTH
H	MA	Jung⁶⁹	2022	TTH
H	MA	Kamonseki⁷⁰	2022	TTH
H	MA	Kang⁷¹	2022	TTH
A	MA	Kolokotsios⁷²	2021	TTH
H	MA	Krøll⁷³	2021	TTH
H	MA	Probyn⁷⁴	2017	TTH
A	SR	Repiso-Guardeño⁷⁵	2022	TTH
H	SR	Skelly³²	2018	TTH
A	MA	Tao⁷⁶	2023	TTH
H	MA	Varangot-Reille⁷⁷	2022	TTH

Article quality assessment: H = high; A = acceptable (using Scottish Intercollegiate Guidelines Network checklist for systematic reviews/meta-analyses and Appraisal of Guidelines for Research and Evaluation Global Rating Scale for clinical practice guidelines).

Study design: CPG, clinical practice guideline; MA = systematic review with meta-analysis; SR, systematic review.

Headache type; CGH, cervicogenic headache; TTH, tension-type headache.

Article quality assessment

All included studies were considered “high” or “acceptable” quality and thus were retained in the analysis (Table 1).

Data extraction

Tables 2 and 3 provide the results of the data abstraction for systematic reviews/meta-analyses of CGH and TTH, respectively. Table 4 summarizes the one included clinical practice guideline. Table 5 provides evidence certainty ratings. Data extracted in our umbrella review synthesis highlighted a greater quantity of literature regarding nonpharmacological interventions for TTH compared with CGH. A single clinical practice guideline provided pertinent recommendations,²⁸ which were considered alongside our updated evidence synthesis when drafting clinical practice guideline recommendations. The certainty of evidence supporting individual treatments varied from “high” to “very low.” We did not downgrade for indirectness, considering the study outcomes aligned with our eligibility framework. We did downgrade when article quality scores indicated risk of bias or publication bias, imprecision with respect to study effect estimates, and inconsistency when study findings varied. The information derived from this synthesis is best interpreted within the context of the guideline recommendations presented below, which are based on included articles’ quality, certainty of evidence, and expert and public feedback.

Table 2.

Systematic Reviews/Meta-Analyses on Cervicogenic Headache.^a

First author	Interventions	# studies	Total n	Evidence certainty	Outcomes
Vázquez-Justes^56a	DN	2 RCTs	180	C	Improvement in all groups DN+Mob > DN or Mob alone DN > sham Acup for function
Pourahmadi^58a	DN	4 RCTs	248	D	DN > other interventions for pain frequency, QoL, trigger point tenderness, and cervical ROM
Aslıyüce⁴⁸	Mob	10 RCTs	465	A–B	Mob = other Mob Mob+DN > DN alone Mob > TE, sham or ST
Cardoso⁵¹	Mob (SNAG)	8 RCTs	357	B	Mob (SNAG) > other treatments
Bini⁵⁰	SMT Mob TE	20 RCTs	1439	B	Short- and long-term: SMT > sham SMT > Mob/modal/ST SMT + DN > Mob
Fernandez⁵³	SMT	7 RCTs	403	B	Short-term: SMT > other treatments for pain intensity, frequency and disability, but not pain duration
Núñez‐Cabaleiro⁵⁴	SMT Mob	11 RCTs, 3 quasi-exp	938	B	Upper cervical SMT > other treatments ST superior in short-term (immediate improvement)
Coelho^55a	SMT Mob	5 RCTs	407	C	SMT+Mob = Conservative at 1 and 3 months
Becher⁴⁹	TE	11 RCTs	594	C–D	TE = Mob = ST (fascial manipulation) TE > other treatments and/or sham
Demont⁵²	TE SMT (cervical or thoracic), ST (TPT), Mob	14 RCTs	1112	B	SMT, ST, Mob > other treatments in the short term TE (neck) > other treatments in long-term

This table includes only the CGH data from studies which include both CGH and TTH. Table 3 includes data on TTH from those studies (no study data are duplicated).

Acup, acupuncture; DN, dry needling; Mob, mobilization; RCT, randomized controlled trial; SMT, spinal manipulative therapy; Quality (A, high; B, moderate; C, low; D, very low); SNAG, sustained natural apophyseal glides; TE, therapeutic exercise.

Table 3.

Systematic Reviews/Meta-Analyses on Tension-Type Headache

First author	Intervention(s)	# studies	Total n	Evidence certainty^c	Outcomes
Hu⁶⁶,a	Acu EAcu EAcu + CT	11 RCTs 1 RCT 1 RCT	569 146 163	B–C	Acu > WM EAcu not superior to WM EAcu + CT > WM
Huang⁶⁷	Acu	8 SRs	11,172	C	Acu effective for TTH
Kang⁷¹	Acu	30 RCTs	2742	C	Acu > sham Acu for pain frequency Acu > medication for pain intensity
Kolokotsios⁷²	Acu	15 RCTs	1272	A	Acu not superior to Sham for pain frequency In the long-term, Acu > Sham for pain intensity
Repiso-Guardeño⁷⁵	Acu TE SMT Mob ST Edu MM Modal	15 RCTs	1229	B	Short-term effectiveness: ST SMT (upper cervical) Electroacu MM 2–6 months effectiveness: MM Mob Edu ST Acu TE, SMT (upper cervical) Long-term effectiveness: Mob + Edu
Tao⁷⁶	Acu	14 RCTs	2795	C–D	Acu > SC or NoT
Pourahmadi⁵⁸,b	DN	4 RCTs	270	D	DN > other interventions for frequency, QoL, trigger point tenderness, and cervical ROM, but not pain intensity
Rehman, (Aemaz)⁵⁹	MM	2 RCT	92	D	NS in MA
Anheyer⁶¹	MM	2 RCT	92	D	NS in MA
Probyn⁷⁴	MM Edu	4 RCTs	177	C	MM or Edu > SC for pain intensity, disability, QoL, medication consumption, mood but not frequency
Jiang⁶⁸	Mob + ST (suboccipital)	6 RCTs	505	B	Mob + ST (combined) effective at 4 weeks, no difference at 8 weeks
Krøll⁷³	Mob, TE, MM, Acu	13 RCTs	Not specified	C–D	Positive effect for frequency and QoL: Acupuncture Mob Positive effect for frequency and intensity TE
Cumplido-Trasmonte⁶²	MT (SMT Mob ST)	10 RCTs	595	B	MT (combined SMT, Mob, ST) > other interventions
Coelho⁵⁵,b	SMT Mob	4 RCTs	386	C	SMT+Mob > other interventions for disability and pain but not frequency at 1–4 wk.
Jung⁶⁹	SMT Mob Modal ST TE	20 RCTs	1220	B	Combined SMT, modal, ST, TE, Edu > medical care
Skelly³²	SMT MM (CBT) Acu	2 RCTs 3 RCTs 2 RCTs	201 198 119	C C C	SMT > SC Insufficient evidence Insufficient evidence
Kamonseki⁷⁰	SMT (HVLA), ST, DN	15 RCTs	1331	B–D	Pain intensity and frequency: ST > NoT DN > NoT HVLA SMT not superior to NoT
Falsiroli Maistrello⁶³	ST (TPT)	5 RCTs	298	D	ST (TPT) > minimal active interventions for reduction of frequency, intensity, and duration
Hall⁶⁵	Tai Chi	1 RCT	47	D	Tai Chi > NoT
Varangot-Reille⁷⁷	TE	5 RCTs	296	D	TE (strength) improved pain intensity, frequency, disability and QoL
Machado-Oliveira⁵⁷	TE (RE)	4 RCTs	300	B	TE (RE) > other treatments
Fan⁶⁴	Tuina (Mob + ST)	7 RCTs	1228	C	Tuina > medication
Anheyer⁶⁰	Yoga	2 RCT	63	D	NS in meta-analysis

For this study, we only included the 13 RCTs that compared standard acupuncture, electroacupuncture, and cupping to “western medicine,” which was not defined in the article. Other interventions included acupuncture methods not likely to be used by chiropractors in the United States with acupuncture certification.

This table includes TTH data from studies which include both CGH and TTH as well as those with only TTH.

Acup, acupuncture; CGH, cervicogenic headache; CT, cupping therapy; DN, dry needling; EAcu, electroacupuncture; Edu, education; QoL, quality of life; modal, modalities; MM, mindfulness meditation; Mob, mobilization; NoT, no treatment; NS, not statistically significant; QoL, quality of life; RCT, randomized controlled trial; RE, resistance exercise; SMT, spinal manipulative therapy; ST, soft tissue technique; TE, therapeutic exercise; TPT, trigger point therapy; TTH, tension-type headache; WM, Western medicine.

^cEvidence certainty: A, high; B, moderate; C, low; D, very low.

Table 4.

Prior Clinical Practice Guideline Recommendations for Treating Cervicogenic and Tension-Type Headache²⁸

For/against	Nonpharmacological interventions	Frequency and duration	Evidence
Cervicogenic headache
For	1. Edu 2. TE (low-load cervicocranial or cervicoscapular exercise) 3. SMT with or without Mob to the cervical and thoracic spine	1. NA 2. ≤8 visits; 6 weeks 3. ≤10 visits; 6 weeks	1. NA 2. 1 low RoB RCT 3. 3 low RoB RCTs
Against	1. Multimodal (SMT, Mob and TE)	1. NA	1. 2 low RoB RCTs
Episodic tension-type headache
For	1. Edu 2. TE (low‐load endurance craniocervical and cervicoscapular exercises)	1. NA 2. ≤ 8 visits; 6 weeks	1. NA 2. 1 low RoB RCT
Against	1. SMT	1. NA	1. 1 low RoB RCT
Chronic tension-type headache
For	1. Edu 2. TE (home or clinic: warm‐up, neck and shoulder stretching and strengthening, aerobic exercise) 3. TE (low‐load endurance craniocervical and cervicoscapular exercises) 4. Multimodal care (Mob, TE, postural correction) 5. Massage	1. NA 2. ≤8 sessions; 12 wk 3. ≤8 sessions; 6 wk 4. ≤9 sessions; 8 wk 5. 2 sessions; 4 weeks	1. NA 2. 1 low RoB RCT 3. 1 low RoB RCT 4. 1 low RoB RCT 5. 1 low RoB RCT
Against	1. SMT	1. NA	1. 1 low RoB RCT

Edu, education; Mob, mobilization; NA, not applicable; RCT, randomized controlled trial; RoB, risk of bias; SMT, spinal manipulative therapy; ST, soft tissue; TE, therapeutic exercise; TTH, tension-type headache.

Table 5.

Summary of Findings for Interventions for Cervicogenic and Tension-Type Headache

Intervention and condition	Summary of findings and reasons for downgrade	Certainty	Recommendation
Dry needling for CGH	Most recent, acceptable-quality, SR included two RCTs of acceptable and high quality for frequency and duration⁵⁶ (risk of bias)	B	In favor
Joint mobilization for CGH	Multiple acceptable to high-quality SRs of multiple RCTs with varied quality for intensity, frequency, and disability^{48,50–52,55,62} (risk of bias)	B	In favor
Spinal manipulative therapy for CGH	High-quality SRs and CPG including multiple high-quality RCTs for frequency and intensity^{28,50,52–55}	A	In favor
Multimodal therapies for CGH	Based on high quality SR and acceptable-quality CPG including multiple acceptable to-high-quality RCTs combining spinal and soft tissue manipulation and joint mobilization intensity and frequency^28,52 (risk of bias)	B	In favor
Soft tissue manipulation for CGH	SR of multiple RCTs combining ST with other manual therapies for frequency and intensity⁵² (indirectness)	B	In favor
Therapeutic exercise for CGH	Based on two SRs of two RCTs having moderate and high-quality for intensity and disability^50,52 (imprecision)	B	In favor
Acupuncture for TTH	Multiple high- or acceptable-quality SRs including several RCTs with varying quality for frequency and intensity^{66,67,71,72,75,76} (risk of bias)	B	In favor
Dry needling for TTH	Two SRs based on multiple RCTs for intensity and frequency^58,70 (risk of bias)	C	In favor
Electroacupuncture for TTH	Single very-low certainty effect derived from SR including two RCTs showing no effect for intensity and frequency⁶⁶ (risk of bias, imprecision)	D	No effect
Mindfulness medication or psychological self-care for TTH	In most recent SR, three RCTs focused on TTH specifically and there was no subgroup analysis for TTH for frequency, intensity, or duration⁵⁹ (imprecision)	C	No effect
Joint mobilization for TTH	Two SRs, one of which being network meta-analysis with multiple RCTs for intensity and frequency^68,69 (imprecision)	B	In favor
Modality: Transcutaneous electrical nerve stimulation for TTH	Based on SR with multiple RCTs, yet only examined as an isolated therapy in a single RCT, with effect crossing null in network meta-analysis (imprecision)⁶⁹	B	No effect
Spinal manipulative therapy for TTH	Based on SRs including two low-to-acceptable quality RCTs supporting efficacy³² and one high-quality RCT showing no effect for intensity²⁸ (risk of bias, inconsistency)	C	In favor
Multimodal therapies for TTH	SR including two RCTs showed soft tissue and spinal manipulation were superior to soft tissue manipulation alone for intensity (imprecision)⁶⁸	B	In favor
Soft tissue manipulation for TTH	SRs including multiple RCTs with varying quality, with significant effect favoring therapy in network meta-analysis for frequency and intensity, dependent upon comparator^32,69,70 (risk of bias, heterogeneity)	C	In favor
Therapeutic exercise for TTH	SRs of multiple acceptable-quality RCTs including network meta-analysis showing wide confidence intervals for intensity and frequency.^57,69,73,77 (imprecision)	B	In favor
Tuina for TTH	Single SR of multiple low-quality RCTs demonstrating significant effect on intensity⁶⁴ (risk of bias)	C	In favor

We were unable to derive an evidence certainty or recommendation for the following intervention-condition pairs as no available evidence was identified: acupuncture, electroacupuncture, education, mindfulness medication or psychological self-care, modalities, and Tuina for cervicogenic headache (CGH); education for tension-type headache (TTH). Multimodal therapies are defined as any combination of spinal manipulative therapy, joint mobilization, soft tissue manipulation, and modalities. The certainty of evidence ranges from A (highest) to D (lowest) as defined in Supplementary file 2 Supplementary Table S3: A, high; B, medium; C, low; D, very low. RCT, randomized controlled trial; SR, systematic review.

Modified Delphi consensus process

Of 73 individuals invited, 58 accepted (80%). One panelist did not respond after accepting, thereby yielding 57 final panelists. Of the 57, 43 (75%) identified as male and 49 (86%) as white. There were two who identified as Black/African American (5%); two as Hispanic (4%); and one each as Asian (2%), Native American (2%), and multiracial (2%). Fifty-five were doctors of chiropractic (96%); there was one medical physician (Family Medicine; 2%) and one pharmacist (2%). Seven doctors of chiropractic were cross-trained (12%): seven in acupuncture (11%) and one in nursing (Bachelor of Science in Nursing; 2%). Eight of the doctors of chiropractic had academic master’s degrees (Master of Arts, Master of Public Health, or Master of Science; 14%). Nineteen (33%) of the panelists are employed by a Veterans Administration facility. One panelist was a faculty member at a chiropractic college (2%), and two were faculty at nonchiropractic institutions (4%). Fifty-two were practitioners (91%) with a mean time in practice of 24 years (min–max: 1–45). The 52 practitioners reported a mean of 84 patient visits per week (min–max: 6–650). The mean estimated proportion of their patients with a chief complaint of headache was 17% (min–max: 2–80%). Panelists’ locations represented 28 US’ states as follows: five from New York (9%); four each from Arizona, Florida, and Wisconsin (7% each); three each from California, Kansas, New Hampshire, Oregon, Texas, and Washington (5% each); two each from Iowa, Missouri, Pennsylvania, and South Dakota (4% each); and one each from Colorado, Georgia, Hawaii, Illinois, Kentucky, Maryland, Michigan, Minnesota, Mississippi, Montana, New Jersey, Ohio, Rhode Island, and Tennessee (2% each).

On Delphi Round 1, the panel reached consensus (>80% agreement) on 21 of the 31 recommendations (68%). Comments indicated the primary reason for disagreement was a need for greater clarity of the recommendations for interventions, rather than disagreement with the statements’ evidence base. The steering committee clarified the statements after reviewing the panelists’ comments. Agreement was reached for all but one statement in Round 2. Round 3 consisted of a revision of that statement, clarifying the recommendation concerning the appropriateness of dry needling for CGH; the panelists then reached consensus.

Public comments

Five comments were submitted by four individuals (all doctors of chiropractic) during the 28-day comment period. The comments were deidentified and sent to the steering committee, who carefully considered each comment. One commenter requested a greater level of detail in the outcome measures recommendations to comply with Centers for Medicare and Medicaid Services regulations; the steering committee agreed this was not within the purview of making evidence-based recommendations. Another commenter requested consideration of additional conditions and medications as red flags; however, the steering committee agreed that these additions would be redundant with the history taking statements. The third and fourth commenters were concerned with contraindications and precautions regarding transcutaneous electrical nerve stimulation and high-velocity, low-amplitude spinal manipulative therapy for complicated or late pregnancy (Table 6) and provided several references. The steering committee considered their citations, conducting targeted literature searches on these topics. They concluded that the language used for contraindications/precautions was ambiguous, found more clearly delineated definitions, and changed five of the recommendations from “possible contraindication” to “precaution.” This necessitated an additional Delphi round to reach consensus. The Delphi panel reached at least 80% consensus on four of the statements, with a response rate of 95% (54 of 57 panelists). They did not reach agreement on the fifth revised statement (on transcutaneous electrical nerve stimulation), so it was retained in its original form.

Table 6.

Precautions and Contraindications for Nonpharmacological Interventions

Condition	Cervical HVLA manipulation^a	Cervical mobilization^b	Soft tissue techniques^c	Needling therapy	Therapeutic exercise	TENS
Active spinal infection	C	C	C	C	C	C
Active inflammatory arthritis	C	C	✓	✓	✓	✓
Anticoagulation therapy	P	✓	P	P⁷⁸	✓	✓
Cervical artery dysfunction^d	C	P	P	✓	C	✓
Cervical ligamentous instability	C	✓	✓	✓	P	✓
Degenerative cervical myelopathy	C	✓	✓	✓	P	✓
Complicated or late (37+ weeks) pregnancy	P^79–83	✓	✓	P⁸⁴	✓	C⁸⁵
Spinal metastasis	C	P	P	P	P⁸⁶	P⁸⁷

Application of high-velocity, low-amplitude biomechanical force to a joint.⁸⁸

Application of low-velocity biomechanical force to a joint.⁸⁸

Including instrument-assisted soft tissue techniques.

Examples include aneurysm, atherosclerosis, dissection, thrombosis, and vascular anomalies.

*Symbols: C represents contraindication, defined as a condition or factor for which the intervention should be avoided; P indicates precaution, defined as a case in which the intervention should be applied with special care or limitations,⁸⁹ and ✓ indicates there is typically no contraindication in this context. Certainty C, Strength ↑↑.

Evidence-based recommendations reaching consensus

Following each statement is the rating for certainty of evidence, as described in Supplementary Data S2, Supplementary Table S3, and strength of recommendation (strength) as strong ↑↑ or weak ↑.⁴⁰ Below are the finalized recommendations in the clinical practice guideline.

Informed consent/risks and benefits

IC1

Informed consent is a process involving direct communication between the clinician and patient. Explain all procedures, including examination, diagnosis and treatment options (including no treatment) in terms the patient understands. Explain both benefits and risks.⁴⁴ Ask the patient if they have any questions; answer them and affirm that the patient understands, in order to inform shared decision-making.⁴⁴ Record the discussion and patient’s consent in the medical record. Certainty D, strength ↑↑.

IC2

Adhere to local/regional legal requirements. If necessary, seek advice on compliance from the state licensing board. Additional guidance is available from the American Chiropractic Association and the Association of Chiropractic Colleges. Certainty D, strength ↑↑.

History

H1

Record a history that includes current symptoms, health status, previous and concurrent treatment, and psychosocial factors. Components should include:^29,38 Certainty B, strength ↑↑. 1.

Assessment of red/orange flags^29–31 (Supplementary Data S2, Supplementary Table S4) and possible contraindications for nonpharmacological interventions, with particular emphasis on high-velocity, low-amplitude spinal manipulation^{79–85,87,89} (Table 6)

Assessment of yellow flags (i.e., psychosocial factors that may influence the treatment response)³¹

History of significant and/or recent physical trauma

Headache onset, characteristics, and precipitating factors

Pain type, severity, location, frequency, and duration

Provocative and relieving factors

Previous interventions and response

Current and previous self-care strategies

Diagnostic tests and results

10.

Current medications, both prescription and nonprescription, particularly those for HA

11.

Current nutraceuticals and supplements

12.

Comorbidities, family history

13.

Lifestyle factors such as diet, sleep quality, physical activity, alcohol, tobacco, and recreational drug use.

Diagnostic considerations

D1

Establish a working diagnosis of CGH or TTH from the history and examination.³⁶ Certainty A, Strength ↑↑.

Definitions

The following material is based on diagnostic criteria from The International Classification of Headache Disorders, 3rd edition:³⁶

TTH is classified as a primary headache with palpable pericranial tenderness, typically bilateral. It is characterized as episodic (infrequent or frequent) or chronic.³⁶ Infrequent episodic TTH occurs less than once a month and is not addressed in this guideline. Frequent episodic TTH is characterized by at least 10 episodes occurring on 1–14 days/month on average for >3 months and does not exhibit the additional symptoms characteristic of migraine. Chronic TTH is similar to frequent episodic except that it occurs more than 15 days/month for at least 3 months.³⁶

CGH is classified as a secondary headache caused by a disorder of the cervical spine and its related structures (bone, disc, and/or soft tissue), usually but not always associated with neck pain. When cervical myofascial pain is the cause, the headache is more appropriately classified as TTH.³⁶

Diagnosis of CGH

D2

Diagnosis of CGH relies on clinical and/or imaging evidence of a cervical spine disorder, reasonable exclusion of other headache disorders, and any one of the following:³⁶ Certainty B, strength ↑↑ 1.

Temporal relation to cervical disorder

Symptoms correlate with cervical disorder (e.g., symptoms improve/resolve in parallel with improvement or resolution of the cervical disorder)

Reduced cervical range of motion or exacerbation of headache with provocative maneuvers

Headache alleviated after diagnostic block.

Diagnosis of TTH

D3

TTH is diagnosed based on recurrent episodes of typically bilateral, pressing, or tightening headaches lasting from minutes to days, which are mild to moderate in intensity, and examination findings of pericranial tenderness (i.e., frontal, temporal, masseter, pterygoid, sternocleidomastoid, splenius, and trapezius muscles).³⁶ TTH is not aggravated by routine physical activities and never includes moderate or severe nausea or vomiting, yet it may include one of photophobia, phonophobia, or mild nausea. Other headaches should be ruled out although TTH may overlap with migraine features. Certainty B, strength ↑↑.

D4

There may be overlap or difficulty making distinctions between TTH and migraine. Certainty B, strength ↑↑.

Examination

E1

For suspected TTH or CGH, conduct a physical examination focusing on musculoskeletal and neurological components related to the neck and head, including an assessment of pain and/or tenderness upon palpation of the neck, pericranial region, and appropriate provocative testing for the cervical spine when indicated.^28,90 Certainty A, strength ↑↑.

Diagnostic imaging

DI1

Routine diagnostic imaging is not recommended for patients with already-diagnosed cervicogenic or TTH.^{28,29,38,90,91} Certainty A, strength ↑↑.

Factors which indicate the need for imaging are: 1.

Red flags on history or physical exam

Severe and/or progressive neurological deficits

No improvement after a reasonable course (4–6 weeks) of care.

General management considerations

See Figure 2 for general care pathway.

FIG. 2.

Care pathway for patients with cervicogenic or tension-type headache. HA, headache; MMI/MTB, maximum medical improvement or maximal treatment benefit; PROMs, passive ranges of motion; ROM, range of motion.

G1

For patients with contraindications, or who do not adequately respond to an initial course of approximately 4 weeks of conservative care, consider referral to and/or co-management with appropriate pharmacological providers or medical specialists for further evaluation and/or management of TTH/CGH.³⁸ Certainty B, strength ↑↑.

G2

Select intervention strategies that are congruent with patient preference, are without contraindications, and emphasize patient-centered care.^28,37,90 Certainty B, strength ↑↑.

Outcome assessment

O1

Consider using patient-reported outcome measures to assess patient pain and function, and to assess progress over time. Certainty B, strength ↑↑.

Examples of validated instruments are pain intensity: Numeric Pain Rating Scale; function/disability: Neck Disability Index.

Examples of validated headache-specific instruments are:

Headache Impact Test 6-item.⁹²

Headache Disability Index.⁹³

Considerations for frequency and duration of treatment

F1

Administer any of the recommended interventions 1–2× per week for 4 weeks to 3 months, depending on clinical context (e.g., headache frequency/intensity), response to a trial of care, and patient preference (during or between headache episodes).^27,28,54,69 Certainty C, strength ↑↑.

F2

Continue the course of care that best manages the patient’s headache pain intensity, frequency, and duration. Certainty C, strength ↑↑.

F3

Administer passive ranges of motion at endpoint of trial of care to assess response. Certainty B, strength ↑↑.

CGH interventions

CGH1

Offer spinal manipulation.^{28,50,52–55} Certainty A, strength ↑↑.

CGH2

Offer multimodal therapy that includes spinal manipulation and any combination of joint mobilization, soft tissue, and/or modalities.²⁸ Certainty B, strength ↑.

CGH3

Consider offering or referring for dry needling when appropriate (e.g., to address suspected trigger points of the cervical spinal musculature).^56,58 Certainty B, strength ↑.

CGH4

Provide therapeutic exercises in a multimodal program (e.g., stretching, strengthening, endurance, and/or postural correction) and/or select individual exercises guided by patient preference.^28,49,50,52 Certainty B, strength ↑.

TTH interventions

TTH1

Provide spinal manipulation combined with joint mobilization, soft tissue techniques, and/or modalities.³² Certainty B, strength ↑.

TTH2

Offer joint mobilization and/or soft tissue techniques.^32,68–70 Certainty B, strength ↑↑.

TTH3

Offer or refer for self-management strategies such as patient education, relaxation, and mindfulness-based stress reduction).^37,74 Certainty C, strength ↑↑.

TTH4

Consider offering or referring for acupuncture, electroacupuncture, or dry needling as part of a multimodal approach.^{58,66–68,70–72,75,76} Certainty B strength ↑↑.

Discussion

The present umbrella review and clinical practice guideline builds upon prior recommendations regarding chiropractic and nonpharmacological management of CGH and TTH by encompassing a broader range of therapies^27,28 and including a more comprehensive focus regarding patient evaluation and management. All recommendations were derived after synthesizing recent evidence from an umbrella review of the literature and attaining consensus from a large multidisciplinary panel. Several recommendations in this study differed from previous headache clinical practice guidelines, reflecting the higher certainty evidence due to the accumulation of more randomized controlled trials and systematic reviews regarding CGH and TTH. Considering the new and updated material focusing on broad aspects of care including diagnosis, history taking, treatment, and care management, the present guideline helps address gaps in prior guidance and aims to support chiropractors in their daily clinical decision-making.

Two statements on the topic of informed consent attained a strong recommendation despite being based on a very low certainty of evidence (i.e., D; ↑↑). Accordingly, this strongly encourages chiropractors to obtain informed consent despite limited evidence. The rationale for this apparent discrepancy stems from the source of evidence. Congruent with our approach to evidence certainty ratings, the supporting evidence for informed consent was based on consensus, expert opinion, and legal precedent, rather than arising from systematic reviews of randomized controlled trials. The informed consent example illustrates the necessity of separately evaluating certainty of evidence and strength of recommendation in guidelines, as these ratings may stem from distinct factors.^94,95

The present clinical practice guideline makes a strong recommendation to offer spinal manipulative therapy for CGH based on high certainty evidence, yet it gives a weak recommendation to avoid spinal manipulative therapy as a stand-alone treatment for TTH based on low certainty evidence. This clinical practice guideline makes a weak recommendation to provide spinal manipulative therapy alongside other therapies for both CGH and TTH based on moderate certainty evidence. While prior clinical practice guidelines had already recommended spinal manipulative therapy for CGH,^27,28 a clinical practice guideline in 2019 recommended avoiding spinal manipulative therapy for TTH.²⁸ In contrast to this prior recommendation, our findings were based on a larger number of studies and enabled a recommendation to use this therapy within a multimodal treatment strategy.

In a clinical practice guideline regarding the prescription of opioids published in 2022, the United States Centers for Disease Control and Prevention recommended the use of nonopioid therapies for individuals with subacute and chronic pain in the absence of serious pathology.⁹⁶ One of the recommendations was to use spinal manipulative therapy for TTH. In addition, the Centers for Disease Control and Prevention highlighted the relevance of patient preference when selecting therapies and that nonpharmaceutical treatments should be the initial approach to TTH and CGH. In the context of the current opioid epidemic, and considering patients’ potential preference to avoid opioids, our clinical practice guideline recommendation to use spinal manipulative therapy for TTH aligns with those of the Centers for Disease Control and Prevention.

New recommendations herein, which were not found in a prior similar clinical practice guideline for chiropractors, address specific elements of diagnostic criteria, history taking, red, yellow and orange flag screening, referral, and outcome assessment.²⁷ While our statements were based on moderate certainty evidence, each received a strong recommendation, highlighting the consensus around their necessity and importance in clinical decision-making for CGH and TTH. In addition, three of our statements regarding formulating a working diagnosis, conducting a physical examination, and avoiding routine diagnostic imaging received a strong recommendation based on high-certainty evidence.

The present clinical practice guideline also derived several statements that were based on a low certainty of evidence, suggesting additional research is needed to increase the certainty around these recommendations. One key example was the treatment frequency for headaches. While a prior clinical practice guideline arrived at more specific recommended frequencies and durations of care, our steering committee and Delphi panel were unable to derive similar statements due to the heterogeneity of the intervention characteristics included among relevant studies.^27,28,54,69 Similarly, recommendations regarding self-management, soft-tissue therapies, dry needling, and mindfulness-based treatments were based only on moderate certainty evidence.

Other therapies had varying strengths of recommendation, based on a moderate certainty of evidence, including dry needling and therapeutic exercise for CGH (both having a weak recommendation), and acupuncture for TTH (strong recommendation). There was insufficient evidence to provide a recommendation either for or against several interventions that are potentially used for CGH such as acupuncture, education, meditation/mindfulness, and modalities used in isolation. Similarly, a weak recommendation was made to use electroacupuncture for TTH based on very low certainty evidence. Finally, we generally found a greater quantity and scope of available evidence for nonpharmacological treatments for TTH compared with CGH. These shortcomings reflect the gaps in the available literature and suggest randomized controlled trials should be conducted to continue examining a range of nonpharmacological interventions for CGH and TTH.

The Clinical Compass group, potentially including one or more of the current authors, expects to update the present guideline within 5–10 years using similar methods. Implementation of the present guidelines may be assessed through real-world longitudinal observational cohort studies, surveys, and cross-sectional analyses of large databases or registries. This may include an assessment of the clinical decision-making characteristics as well as treatments rendered for TTH and CGH.

Strengths and limitations

The present clinical practice guideline was strengthened by the review methods that were registered a priori, comprehensive search strategy, linkage between evidence and recommendations, incorporation of a large Delphi panel, and transparent team involvement and strategies.

Several limitations are noteworthy. Individualizing recommendations according to the frequency, duration, or chronicity of headaches (e.g., episodic vs. chronic TTH) was not feasible due to the lack of consistent definitions regarding these characteristics of the study populations among included studies. For TTH, the synthesized literature frequently did not analyze separate subgroups such as episodic versus chronic TTH, often due to primary randomized controlled trials including both types of TTH.^{55,60,62–64,66,69–72,76,77} As a result, there are instances where clinicians must rely upon the clinical expertise aspect of the evidence triad.⁹⁷ Future chiropractic clinical practice guidelines could also consider another common headache subtypes, migraine and concussion, which were beyond the scope of the present study. Meta-analysis based on raw data from randomized controlled trials was beyond our scope given the range of therapies assessed and corresponding strategy to focus on systematic reviews rather than primary studies. We did not consistently record individual justifications for downgrades in evidence certainty ratings, nor did we calculate kappa values to quantify agreement between assessors. While the data range was short (2017 onward), our approach obviated the need to include older studies, as these were inherently included within and/or superseded by more recent systematic reviews, which were included in this study. The Delphi consensus approach, while rigorous, is susceptible to bias due to the subjectivity and variability inherent among experts when interpreting evidence. Our restriction to English-language articles may have excluded relevant studies or guidelines, leading to language bias. However, two factors may have mitigated this potential bias. First, several of the systematic reviews we included had no language restrictions^58,76,77 or incorporated studies published in non-English languages,^{50–52,56,60–64,66,68,69,75} and second, most systematic reviews and clinical practice guidelines are published in English.⁹⁸ Our use of predefined values for Scottish Intercollegiate Guidelines Network scores removes expert determination that may weigh certain items higher than others. Accordingly, article quality scores may have varied using different methods. This review and guideline did not assess the incidence of risks associated with chiropractor-delivered interventions for those with TTH/CGH, which was outside the scope of our primary objectives. Mild adverse events, such as transient muscle soreness or discomfort, are commonly reported with interventions such as spinal manipulative therapy, while serious adverse events are estimated at 1 per 2 million manipulations to 13 per 10,000 patients and may be better assessed through synthesis of large observational studies.^99,100 Our guideline lacked a statement addressing marital status, work habits, family life, and leisure activities. These factors could be explored during history taking as they may influence headache frequency and/or severity.¹⁰¹ Our guideline lacked specific recommendations on which components of the general physical or neurological examination should be conducted (e.g., blood pressure, cranial nerve assessment, and reflexes). Notably, blood pressure measurement has been encouraged by a previous guideline focusing on headache management in primary care settings.³⁸ Our recommendations did not differentiate between types of patient encounters (e.g., new vs. established patients or new vs. recurring headache presentations) or provide descriptive vignettes to guide interpretation. Accordingly, the utility of history taking and physical examination was left to the panelists’ judgment. Future guidelines may provide more explicit guidance regarding the frequency, timing, and clinical context of these recommendations. Our guideline did not evaluate the role of imaging in the initial diagnosis of CGH or TTH. While radiographs or magnetic resonance imaging may occasionally assist in differential diagnosis or help identify cervical spine pathology in suspected CGH, imaging findings are common among individuals without headache and are not required by The International Classification of Headache Disorders, 3rd edition for CGH diagnosis.³⁶ Recent evidence also indicates a lack of positive correlation between degenerative cervical magnetic resonance imaging findings and headache severity, suggesting limited diagnostic utility of imaging in CGH.¹⁰² Future guideline updates could address appropriate indications and timing of imaging in greater detail. The present recommendations are not generalizable to pediatric populations and do not apply to those with serious pathology (e.g., cancer, infection, and spinal fracture).

Conclusions

This clinical practice guideline provides evidence-based consensus statements for nonpharmaceutical management of CGH and TTH in adults. Among other statements, recommendations encouraged a history and examination and use of spinal manipulative therapy for patients with CGH, whereas patients with TTH should receive spinal manipulative therapy as a component of multimodal care. In addition, our guideline highlights the lack of high certainty evidence, which precludes our ability to derive strong statements for several other nonpharmacological therapies such as acupuncture, education, meditation/mindfulness, and modalities used in isolation for CGH and electroacupuncture for TTH. This guideline provides evidence-informed direction to chiropractors regarding which nonpharmacological interventions are appropriate to consider for CGH and TTH in adults.

Ethics Approval and Consent to Participate

The Institutional Review Board of Texas Chiropractic College approved the project. All Delphi panelists consented to participate in the study.

Consent for Publication

All Delphi panelists consented to being acknowledged in the article.

Competing Interests

C.J.D., L.S.C., and S.A.M. are board members for Clinical Compass. C.J.D. is a member of the Washington State Health Technology Clinical Committee. K.R.A. is on the Board of Governors for the American Chiropractic Association. The authors have no additional conflicts to declare.

Authors’ Contributions

Study methodology was developed by R.J.T., C.J.D., C.H., D.N.T., S.A.W., M.R.P., K.R.A., L.S.C., S.A.M., C.A.S., and C.B.O. S.A.W. conducted the literature search. C.J.D. and C.H. secured funding. C.H. provided supervision and was responsible for the software and data analysis. Data curation was performed by R.J.T., C.J.D., C.H., D.N.T., and M.R.P. The investigation was carried out by R.J.T., C.J.D., C.H., D.N.T., S.A.W., M.R.P., K.R.A., L.S.C., S.A.M., and C.A.S. R.J.T. and C.H. prepared the first draft of the article, whereas R.J.T., C.J.D., C.H., D.N.T., S.A.W., M.R.P., K.R.A., L.S.C., S.A.M., C.A.S., and C.B.O. contributed to article revisions and editing.

Footnotes

Acknowledgments

The authors thank project coordinator, Cathy Evans, for her expert management of the consensus process and all project communications. The authors also thank the Delphi panelists for their generous contribution of their time and expertise to the consensus process: Logan Benjamin, DC, CSCS; Wayne Bennett, DC, DABCO; Craig R. Benton, DC; Derrell Blackburn, DC, MBA; Charles L. Blum, DC, CSCP; Gina M. Bonavito-Larragoite, DC, MBA; Amanda G. Brown, DC, PSP; Wayne H. Carr DC, DACRB, CCSP, AFMCP, CCA; Jeffrey R. Cates, DC, MS; Richard L. Cole, DC, DACNB, FICCN, DAAPM, FICC; Matthew Coté, DC, MS; Thomas Cotter, DC, DACRB; Diana Cowell, PharmD, MBA, BCPS; Zachary A. Cupler, DC, MS; Monica Curruchich, DC, RN, BSN; John Curtin, MSS, DC, DACO, CCIC; Mark D. Dehen, DC, FICC; Paul M. Ettlinger, DC; Jason T. Evans, DC, DIBCN, FIACN, ABIME, NASM; David Folweiler, DC, DACRB; Jonathan Free, DC; Margaret Freihaut DC; William P. Gallagher Jr., DC, CMVI; Justin Goehl, DC, MS; Kyle B. Hammes, DC; Jerrell Hardison, DC; Huyen “Lily” Ho, DC; Gary Alan Jacob DC, LAc, MPH, DipMDT; Jeffrey M. Johnson, DC; Valerie Johnson, DC, DABCI, DACBN; Gregory Katsaros, DC, DAAPM; Louis A. Kazal, Jr., MD, FAAFP; Robert E. Klein, DC, FACO; Lawrence J Larragoite DC, FIAMA, CFMP; Robert A. Leach, DC, MS, MCHES; Duane Lowe, DC; Eric Luke, DC, MS; Hans Mohrbeck, DC, CCN, CCSM; Mark Mulak, DC, MBA, MS, DACRB, DACBSP®; Marcus Nynas, DC; Juli Olson, DC, DACM, FAIHM; Colette Peabody, DC, MS; Mariangela Penna, DC; Lindsay Rae, DC; Shawn Reince, DC; Jeffrey W. Remsburg DC, MS, DACRB, Cert MDT; Christopher B. Roecker, DC, MS; Vern A. Saboe Jr., DC, DACAN, FICC, DABFP, DIANM; Scott Siegel, DC; Charles A. Simpson, DC, DABCO; Samantha Stolzel, DC, MS; Mignon “Mimi” Sweat, MS, DC; Susan Wenberg, DC, MA; John S. Weyand, DC, DABCO; Clint J. Williamson, DC; Morgan Young, DC.

Author Disclosure Statement

This material is the result of work supported with resources and the use of facilities at VA Puget Sound Health Care System. The views expressed in this article are those of the authors and do not necessarily reflect the official policy or position of the United States Department of Veterans Affairs or the United States Government.

Funding Information

This study was funded in part by Clinical Compass and NCMIC Foundation. Clinical Compass funding partially covered the time and resources of C.J.D., S.A.M., and C.H., whereas NCMIC Foundation funding partially covered the time and resources of C.H. The study received no specific grant and NCMIC Foundation played no role in decision-making.

Availability of Data and Materials

All data generated or analyzed during this study are included in this published article and its supplementary information files.

Supplemental Material

References

Stovner

, Hagen

, Linde

, et al. The global prevalence of headache: An update, with analysis of the influences of methodological factors on prevalence estimates. J Headache Pain, 2022; 23(1):34; doi: 10.1186/s10194-022-01402-2

Jull

. Cervicogenic headache. Musculoskelet Sci Pract, 2023; 66:102787; doi: 10.1016/j.msksp.2023.102787

Knackstedt

, Bansevicius

, Aaseth

, et al. Cervicogenic headache in the general population: The Akershus study of chronic headache. Cephalalgia, 2010; 30(12):1468–1476; doi: 10.1177/0333102410368442

Sjaastad

, Bakketeig

. Prevalence of Cervicogenic headache: Vågå study of headache epidemiology. Acta Neurol Scand, 2008; 117(3):173–180; doi: 10.1111/j.1600-0404.2007.00962.x

Demont

, Lafrance

, Benaissa

, et al. Cervicogenic headache, an easy diagnosis? A systematic review and meta-analysis of diagnostic studies. Musculoskelet Sci Pract, 2022; 62:102640; doi: 10.1016/j.msksp.2022.102640

Ashina

, Mitsikostas

, Lee

, et al. Tension-type headache. Nat Rev Dis Primers, 2021; 7(1):24; doi: 10.1038/s41572-021-00257-2

Fernández-de-las-Peñas

, Plaza-Manzano

, Navarro-Santana

, et al. Evidence of localized and widespread pressure pain hypersensitivity in patients with tension-type headache: A systematic review and meta-analysis. Cephalalgia, 2021; 41(2):256–273; doi: 10.1177/0333102420958384

Gupta

, Kumar

, Luthra

, et al. Polymorphism in apolipoprotein E among Migraineurs and tension-type headache subjects. J Headache Pain, 2009; 10(2):115–120; doi: 10.1007/s10194-008-0094-y

Beliveau

PJH

, Wong

, Sutton

, et al. The chiropractic profession: A scoping review of utilization rates, reasons for seeking care, patient profiles, and care provided. Chiropr Man Therap, 2017; 25:35; doi: 10.1186/s12998-017-0165-8

10.

Himelfarb

, Hyland

, Ouzts

, et al. National Board of Chiropractic Examiners: Practice Analysis of Chiropractic 2020. NBCE: Greeley, CO; 2020.

11.

Fenton

, Fang

S-Y

, Ray

, et al. Longitudinal care patterns and utilization among patients with new-onset neck pain by initial provider specialty. Spine (Phila Pa 1976), 2023; 48(20):1409–1418; doi: 10.1097/BRS.0000000000004781

12.

Hurwitz

. Epidemiology: Spinal manipulation utilization. J Electromyogr Kinesiol, 2012; 22(5):648–654; doi: 10.1016/j.jelekin.2012.01.006

13.

Moore

, Leaver

, Sibbritt

, et al. Prevalence and factors associated with the use of primary headache diagnostic criteria by chiropractors. Chiropr Man Therap, 2019; 27:33; doi: 10.1186/s12998-019-0254-y

14.

Satpute

, Bedekar

, Hall

. Cervical neuro-musculoskeletal impairments in people with Cervicogenic headache: A systematic review and meta-analysis. Phys Ther Rev, 2023; 28(2):88–110; doi: 10.1080/10833196.2023.2187996

15.

Liang

, Galea

, Thomas

, et al. Cervical musculoskeletal impairments in migraine and tension type headache: A systematic review and meta-analysis. Musculoskelet Sci Pract, 2019; 42:67–83; doi: 10.1016/j.msksp.2019.04.007

16.

Minen

, Lindberg

, Wells

, et al. Survey of opioid and barbiturate prescriptions in patients attending a tertiary care headache center. Headache, 2015; 55(9):1183–1191; doi: 10.1111/head.12645

17.

Pershing

, Hirekhan

, Syed

, et al. Documentation of international classification of headache disorders criteria in patient medical records: A retrospective cohort analysis. Cureus, 2024; 16(1):e52209; doi: 10.7759/cureus.52209

18.

Fernández-de-Las-Peñas

, Cook

, Cleland

, et al. The cervical spine in tension type headache. Musculoskelet Sci Pract, 2023; 66:102780; doi: 10.1016/j.msksp.2023.102780

19.

Himelfarb

, Johnson

, Green

, et al. National Board of Chiropractic Examiners: Practice Analysis of Chiropractic 2025. NBCE: Greeley, CO; 2025.

20.

Gevers-Montoro

, Provencher

, Descarreaux

, et al. Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain. Eur J Pain, 2021; 25(7):1429–1448; doi: 10.1002/ejp.1773

21.

Loder

, Weizenbaum

, Frishberg

, et al.; American Headache Society Choosing Wisely Task Force. Choosing wisely in headache medicine: The American headache society’s list of five things physicians and patients should question. Headache, 2013; 53(10):1651–1659; doi: 10.1111/head.12233

22.

Abdel Shaheed

, Ferreira

, Dmitritchenko

, et al. The efficacy and safety of paracetamol for pain relief: An overview of systematic reviews. Med J Aust, 2021; 214(7):324–331; doi: 10.5694/mja2.50992

23.

Machado

, Maher

, Ferreira

, et al. Efficacy and safety of paracetamol for spinal pain and osteoarthritis: Systematic review and meta-analysis of randomised placebo controlled trials. Bmj, 2015; 350:h1225; doi: 10.1136/bmj.h1225

24.

Mafi

, Edwards

, Pedersen

, et al. Trends in the ambulatory management of headache: Analysis of NAMCS and NHAMCS data 1999-2010. J Gen Intern Med, 2015; 30(5):548–555; doi: 10.1007/s11606-014-3107-3

25.

Mitsikostas

, Belesioti

, Arvaniti

, et al.; Hellenic Headache Society. Patients’ preferences for headache acute and preventive treatment. J Headache Pain, 2017; 18(1):102; doi: 10.1186/s10194-017-0813-3

26.

Zhang

, Dennis

, Leach

, et al. Complementary and alternative medicine use among US adults with headache or migraine: Results from the 2012 national health interview survey. Headache, 2017; 57(8):1228–1242; doi: 10.1111/head.13148

27.

Bryans

, Descarreaux

, Duranleau

, et al. Evidence-based guidelines for the chiropractic treatment of adults with headache. J Manipulative Physiol Ther, 2011; 34(5):274–289; doi: 10.1016/j.jmpt.2011.04.008

28.

Côté

, Yu

, Shearer

, et al. Non-pharmacological management of persistent headaches associated with neck pain: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) collaboration. Eur J Pain, 2019; 23(6):1051–1070; doi: 10.1002/ejp.1374

29.

, Remmers

, Schytz

, et al. Red and orange flags for secondary headaches in clinical practice. Neurology, 2019; 92(3):134–144; doi: 10.1212/WNL.0000000000006697

30.

García-Azorín

, Abelaira-Freire

, González-García

, et al. Sensitivity of the SNNOOP10 list in the high-risk secondary headache detection. Cephalalgia, 2022; 42(14):1521–1531; doi: 10.1177/03331024221120249

31.

Stearns

, Carvalho

, Beneciuk

, et al. Screening for yellow flags in Orthopaedic physical therapy: A clinical framework. J Orthop Sports Phys Ther, 2021; 51(9):459–469; doi: 10.2519/jospt.2021.10570

32.

Skelly

, Chou

, Dettori

, et al. Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review. AHRQ: Rockville, MD; 2018.

33.

Chang

. The chiropractic scope of practice in the United States: A cross-sectional survey. J Manipulative Physiol Ther, 2014; 37(6):363–376; doi: 10.1016/j.jmpt.2014.05.003

34.

Brouwers

, Kho

, Browman

, et al.; AGREE Next Steps Consortium. AGREE II: Advancing guideline development, reporting, and evaluation in health care. Prev Med, 2010; 51(5):421–424; doi: 10.1016/j.ypmed.2010.08.005

35.

Hawk

, Whalen

, Farabaugh

, et al. Best practices for chiropractic management of patients with chronic musculoskeletal pain: A clinical practice guideline. J Altern Complement Med, 2020; 26(10):884–901; doi: 10.1089/acm.2020.0181

36.

Headache Classification Committee. The international classification of headache disorders, 3rd edition. Cephalalgia, 2018; 38(1):1–211; doi: 10.1177/0333102417738202

37.

Lin

, Wiles

, Waller

, et al. What does best practice care for musculoskeletal pain look like? Eleven consistent recommendations from high-quality clinical practice guidelines: Systematic review. Br J Sports Med, 2020; 54(2):79–86; doi: 10.1136/bjsports-2018-099878

38.

Steiner

, Jensen

, Katsarava

, et al. AIDS to management of headache disorders in primary care (2nd edition) : On behalf of the European headache federation and lifting the burden: The global campaign against headache. J Headache Pain, 2019; 20(1):57; doi: 10.1186/s10194-018-0899-2

39.

Scottish Intercollegiate Guideline Network (SIGN). Methodology checklists. 2021. Available from: https://www.sign.ac.uk/using-our-guidelines/methodology/checklists/ [Last accessed: June 12, 2024].

40.

Guyatt

, Oxman

, Kunz

, et al.; GRADE Working Group. Going from evidence to recommendations. Bmj, 2008; 336(7652):1049–1051; doi: 10.1136/bmj.39493.646875.AE

41.

Guyatt

, Oxman

, Vist

, et al.; GRADE Working Group. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. Bmj, 2008; 336(7650):924–926; doi: 10.1136/bmj.39489.470347.AD

42.

Brozek

, Akl

, Alonso-Coello

, et al.; GRADE Working Group. Grading quality of evidence and strength of recommendations in clinical practice guidelines. Part 1 of 3. An overview of the GRADE approach and grading quality of evidence about interventions. Allergy, 2009; 64(5):669–677; doi: 10.1111/j.1398-9995.2009.01973.x

43.

Hawk

, Amorin-Woods

, Evans

, et al. The role of chiropractic care in providing health promotion and clinical preventive services for adult patients with musculoskeletal pain: A clinical practice guideline. J Altern Complement Med, 2021; 27(10):850–867; doi: 10.1089/acm.2021.0184

44.

Whalen

, Hawk

, Farabaugh

, et al. Best practices for chiropractic management of adult patients with mechanical low back pain: A clinical practice guideline for chiropractors in the United States. J Manipulative Physiol Ther, 2022; 45(8):551–565; doi: 10.1016/j.jmpt.2023.04.010

45.

Whalen

, Farabaugh

, Hawk

, et al. Best-practice recommendations for chiropractic management of patients with neck pain. J Manipulative Physiol Ther, 2019; 42(9):635–650; doi: 10.1016/j.jmpt.2019.08.001

46.

Fitch

, Bernstein

, Aguilar

, et al. The RAND UCLA appropriateness method user’s manual. RAND Corporation: Santa Monica, CA. 2001.

47.

Hsu

C-C

, Sandford

. The Delphi technique: Making sense of consensus. Pract Assess Res Eval, 2007; 12(10); doi: 10.7275/PDZ9-TH90

48.

Aslıyüce

YÖ

, Ülger

. Mulligan Mobilization for cervicogenic headache - A systematic review. Int J Osteopath Med, 2022; 43:31–38; doi: 10.1016/j.ijosm.2022.03.002

49.

Becher

, Lozano-López

, Castro-Carletti

, et al. Effectiveness of therapeutic exercise for the management of Cervicogenic headache: A systematic review. Musculoskelet Sci Pract, 2023; 66:102822; doi: 10.1016/j.msksp.2023.102822

50.

Bini

, Hohenschurz-Schmidt

, Masullo

, et al. The effectiveness of manual and exercise therapy on headache intensity and frequency among patients with Cervicogenic headache: A systematic review and meta-analysis. Chiropr Man Therap, 2022; 30(1):49; doi: 10.1186/s12998-022-00459-9

51.

Cardoso

, Seixas

, Rodrigues

, et al. The effectiveness of sustained natural Apophyseal glide on flexion rotation test, pain intensity, and functionality in subjects with Cervicogenic headache: A systematic review of randomized trials. Arch Physiother, 2022; 12(1):20; doi: 10.1186/s40945-022-00144-3

52.

Demont

, Lafrance

, Gaska

, et al. Efficacy of physiotherapy interventions for the management of adults with Cervicogenic headache: A systematic review and meta-analyses. Pm R, 2023; 15(5):613–628; doi: 10.1002/pmrj.12856

53.

Fernandez

, Moore

, Tan

, et al. Spinal manipulation for the management of Cervicogenic headache: A systematic review and meta-analysis. Eur J Pain, 2020; 24(9):1687–1702; doi: 10.1002/ejp.1632

54.

Núñez‐Cabaleiro

, Leirós‐Rodríguez

. Effectiveness of manual therapy in the treatment of Cervicogenic headache: A systematic review. Headache, 2022; 62(3):271–283; doi: 10.1111/head.14278

55.

Coelho

, Ela

, Garvin

, et al. The effectiveness of manipulation and mobilization on pain and disability in individuals with Cervicogenic and tension-type headaches: A systematic review and meta-analysis. Phys Ther Rev, 2019; 24(1–2):29–43; doi: 10.1080/10833196.2019.1572963

56.

Vázquez-Justes

, Yarzábal-Rodríguez

, Doménech-García

, et al. Effectiveness of dry needling for headache: A systematic review. Neurologia (Engl Ed), 2022; 37(9):806–815; doi: 10.1016/j.nrleng.2019.09.010

57.

Machado-Oliveira

, da Silva Gauto

, de Santana Neto

, et al. Effects of different exercise intensities on headache: A systematic review. Am J Phys Med Rehabil, 2020; 99(5):390–396; doi: 10.1097/phm.0000000000001349

58.

Pourahmadi

, Dommerholt

, Fernández-de-Las-Peñas

, et al. Dry needling for the treatment of tension-type, Cervicogenic, or migraine headaches: A systematic review and meta-analysis. Phys Ther, 2021; 101(5):pzab068; doi: 10.1093/ptj/pzab068

59.

Aemaz Ur Rehman

, Waseem

, Habiba

, et al. Efficacy of mindfulness-based intervention for the treatment of chronic headaches: A systematic review and meta-analysis. Ann Med Surg (Lond), 2022; 78:103862; doi: 10.1016/j.amsu.2022.103862

60.

Anheyer

, Klose

, Lauche

, et al. Yoga for treating headaches: A systematic review and meta-analysis. J Gen Intern Med, 2020; 35(3):846–854; doi: 10.1007/s11606-019-05413-9

61.

Anheyer

, Leach

, Klose

, et al. Mindfulness-based stress reduction for treating chronic headache: A systematic review and meta-analysis. Cephalalgia, 2019; 39(4):544–555; doi: 10.1177/0333102418781795

62.

Cumplido-Trasmonte

, Fernández-González

, Alguacil-Diego

, et al. Manual therapy in adults with tension-type headache: A systematic review. Neurologia (Engl Ed), 2021; 36(7):537–547; doi: 10.1016/j.nrleng.2017.12.005

63.

Falsiroli Maistrello

, Geri

, Gianola

, et al. Effectiveness of trigger point manual treatment on the frequency, intensity, and duration of attacks in primary headaches: A systematic review and meta-analysis of randomized controlled trials. Front Neurol, 2018; 9:254; doi: 10.3389/fneur.2018.00254

64.

Fan

, Di

, Huang

, et al. The effectiveness and safety of Tuina for tension-type headache: A systematic review and meta-analysis. Complement Ther Clin Pract, 2021; 43:101293; doi: 10.1016/j.ctcp.2020.101293

65.

Hall

, Copsey

, Richmond

, et al. Effectiveness of Tai Chi for chronic musculoskeletal pain conditions: Updated systematic review and meta-analysis. Phys Ther, 2017; 97(2):227–238; doi: 10.2522/ptj.20160246

66.

, Wang

, Jia

, et al. Acupuncture and related therapies for tension-type headache: A systematic review and network meta-analysis. Front Neurol, 2023; 14:1194441; doi: 10.3389/fneur.2023.1194441

67.

Huang

, Shen

, Qin

, et al. Acupuncture for the treatment of tension-type headache: An overview of systematic reviews. Evid Based Complement Alternat Med, 2020; 2020:4262910–4262910; doi: 10.1155/2020/4262910

68.

Jiang

, Li

, Wei

, et al. Effectiveness of physical therapy on the Suboccipital area of patients with tension-type headache: A meta-analysis of randomized controlled trials. Medicine (Baltimore), 2019; 98(19):e15487; doi: 10.1097/md.0000000000015487

69.

Jung

, Eschke

, Struss

, et al. Effectiveness of physiotherapy interventions on headache intensity, frequency, duration and quality of life of patients with tension-type headache. A systematic review and network meta-analysis. Cephalalgia, 2022; 42(9):944–965; doi: 10.1177/03331024221082073

70.

Kamonseki

, Lopes

, van der Meer

, et al. Effectiveness of manual therapy in patients with tension-type headache. A systematic review and meta-analysis. Disabil Rehabil, 2022; 44(10):1780–1789; doi: 10.1080/09638288.2020.1813817

71.

Kang

, Xiao

, Fan

, et al. Acupuncture for tension-type headache: A systematic review and meta-analysis of randomized controlled trials. Front Neurol, 2022; 13:943495; doi: 10.3389/fneur.2022.943495

72.

Kolokotsios

, Stamouli

, Koukoulithras

, et al. The effectiveness of acupuncture on headache intensity and frequency in patients with tension-type headache: A systematic review and meta-analysis. Cureus, 2021; 13(4):e14237; doi: 10.7759/cureus.14237

73.

Krøll

, Callesen

, Carlsen

, et al. Manual joint Mobilisation techniques, supervised physical activity, psychological treatment, acupuncture and patient education for patients with tension-type headache. A systematic review and meta-analysis. J Headache Pain, 2021; 22(1):96; doi: 10.1186/s10194-021-01298-4

74.

Probyn

, Bowers

, Mistry

, et al.; CHESS team. Non-pharmacological self-management for people living with migraine or tension-type headache: A systematic review including analysis of intervention components. BMJ Open, 2017; 7(8):e016670; doi: 10.1136/bmjopen-2017-016670

75.

Repiso-Guardeño

, Moreno-Morales

, Armenta-Pendón

, et al. Physical therapy in tension-type headache: A systematic review of randomized controlled trials. Int J Environ Res Public Health, 2023; 20(5):4466; doi: 10.3390/ijerph20054466

76.

Tao

, Wang

, Feng

, et al. Efficacy of acupuncture for tension-type headache prophylaxis: Systematic review and meta-analysis with trial sequential analysis. J Neurol, 2023; 270(7):3402–3412; doi: 10.1007/s00415-023-11695-1

77.

Varangot-Reille

, Suso-Martí

, Romero-Palau

, et al. Effects of different therapeutic exercise modalities on migraine or tension-type headache: A systematic review and meta-analysis with a replicability analysis. J Pain, 2022; 23(7):1099–1122; doi: 10.1016/j.jpain.2021.12.003

78.

Muñoz

, Dommerholt

, Pérez-Palomares

, et al. Dry needling and antithrombotic drugs. Pain Res Manag, 2022; 2022:1363477; doi: 10.1155/2022/1363477

79.

Hellstenius

. A risk too great? Stroke implications for the pregnant patient: A scoping review. J Clin Chiropr Pediat, 2020; 19(2):1688–1693.

80.

Stickler

, Kearns

. Spinal manipulation and adverse event reporting in the pregnant patient limits estimation of relative risk: A narrative review. J Man Manip Ther, 2023; 31(3):162–173; doi: 10.1080/10669817.2022.2118653

81.

Trager

, Daniels

, Scott

, et al. Pregnancy and spontaneous cervical artery dissection: A propensity-matched retrospective cohort study. J Stroke Cerebrovasc Dis, 2023; 32(11):107384; doi: 10.1016/j.jstrokecerebrovasdis.2023.107384

82.

Weis

, Pohlman

, Barrett

, et al. Best-practice recommendations for chiropractic care for pregnant and postpartum patients: Results of a consensus process. J Manipulative Physiol Ther, 2022; 45(7):469–489; doi: 10.1016/j.jmpt.2021.03.002

83.

Weis

, Stuber

, Murnaghan

, et al. Adverse events from spinal manipulations in the pregnant and postpartum periods: A systematic review and update. J Can Chiropr Assoc, 2021; 65(1):32–49.

84.

Zamora-Brito

, Fernández-Jané

, Pérez-Guervós

, et al. Role of acupuncture in the present approach to labor induction: A systematic review and meta-analysis. Am J Obstet Gynecol MFM, 2024; 6(2):101272; doi: 10.1016/j.ajogmf.2023.101272

85.

Teoli

, An

. Transcutaneous electrical nerve stimulation. In: StatPearls. StatPearls Publishing: Treasure Island (FL); 2024.

86.

Kearns

, Fernández-De-Las-Peñas

, Brismée

J-M

, et al. New perspectives on dry needling following a medical model: Are we screening our patients sufficiently? J Man Manip Ther, 2019; 27(3):172–179; doi: 10.1080/10669817.2019.1567011

87.

Johnson

, Bjordal

. Transcutaneous electrical nerve stimulation for the management of painful conditions: Focus on neuropathic pain. Expert Rev Neurother, 2011; 11(5):735–753; doi: 10.1586/ern.11.48

88.

Funabashi

, Gorrell

, Pohlman

, et al. Definition and classification for adverse events following spinal and peripheral joint manipulation and mobilization: A scoping review. PLoS One, 2022; 17(7):e0270671; doi: 10.1371/journal.pone.0270671

89.

Cameron

. Physical Agents in Rehabilitation from Research to Practice. 4th ed. Elsevier Health Sciences: St. Louis; 2012.

90.

Haldeman

, Johnson

, Chou

, et al. The global spine care initiative: Care pathway for people with spine-related concerns. Eur Spine J, 2018; 27(Suppl 6):901–914; doi: 10.1007/s00586-018-5721-y

91.

Whitehead

, Cardenas

, Corey

, et al. ACR Appropriateness Criteria® headache. J Am Coll Radiol JACR, 2019; 16(11):S364–S377; doi: 10.1016/j.jacr.2019.05.030

92.

Haywood

, Mars

, Potter

, et al. Assessing the impact of headaches and the outcomes of treatment: A systematic review of Patient-Reported Outcome Measures (PROMs). Cephalalgia, 2018; 38(7):1374–1386; doi: 10.1177/0333102417731348

93.

Jacobson

, Ramadan

, Aggarwal

, et al. The henry ford hospital Headache Disability Inventory (HDI). Neurology, 1994; 44(5):837–842; doi: 10.1212/WNL.44.5.837

94.

Klugar

, Kantorová

, Pokorná

, et al. Visual transformation for guidelines presentation of the strength of recommendations and the certainty of evidence. J Clin Epidemiol, 2022; 143:178–185; doi: 10.1016/j.jclinepi.2021.11.009

95.

Qaseem

, Kansagara

, Lin

, et al.; Clinical Guidelines Committee of the American College of Physicians. The development of clinical guidelines and guidance statements by the clinical guidelines committee of the American college of physicians: Update of methods. Ann Intern Med, 2019; 170(12):863–870; doi: 10.7326/M18-3290

96.

Dowell

, Ragan

, Jones

, et al. CDC clinical practice guideline for prescribing opioids for pain — United States, 2022. MMWR Recomm Rep, 2022; 71(3):1–95; doi: 10.15585/mmwr.rr7103a1

97.

Schlegl

, Ducournau

, Ruof

. Different weights of the evidence-based medicine triad in regulatory, health technology assessment, and clinical decision making. Pharmaceut Med, 2017; 31(4):213–216; doi: 10.1007/s40290-017-0197-3

98.

Lunny

, Salzwedel

, Liu

, et al. Validation of five search filters for retrieval of clinical practice guidelines produced low precision. J Clin Epidemiol, 2020; 117:109–116; doi: 10.1016/j.jclinepi.2019.09.022

99.

Chu

EC-P

, Trager

, Lee

LY-K

, et al. A retrospective analysis of the incidence of severe adverse events among recipients of chiropractic spinal manipulative therapy. Sci Rep, 2023; 13(1):1254; doi: 10.1038/s41598-023-28520-4

100.

Swait

, Finch

. What are the risks of manual treatment of the spine? A scoping review for clinicians. Chiropr Man Therap, 2017; 25(1):37; doi: 10.1186/s12998-017-0168-5

101.

Torelli

, Cologno

, Manzoni

. Weekend headache: A possible role of work and life-style. Headache J Head Face Pain, 1999; 39(6):398–408; doi: 10.1046/j.1526-4610.1999.3906398.x

102.

Ziegler

, Iversen

, Hvid

, et al. Association between cervical MRI findings and patient-reported severity of headache in patients with persistent neck pain: A cross-sectional study. Chiropr Man Therap, 2025; 33(1):38; doi: 10.1186/s12998-025-00600-4

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Chiropractic Management of Adults with Cervicogenic or Tension-Type Headaches: Development of a Clinical Practice Guideline

Abstract

Background:

Methods:

Results:

Conclusions:

Keywords

Background

Methods

Steering committee

Seed documents

Literature search

Eligibility criteria

Inclusion criteria

Exclusion criteria

Screening

Evaluation of article quality

Evaluation of evidence certainty

Data extraction

Development of seed statements

Delphi consensus panel

Methodology of the modified Delphi process

Data management and analysis

External review: public comments

Results

Literature search

Article quality assessment

Data extraction

Modified Delphi consensus process

Public comments

Evidence-based recommendations reaching consensus

Informed consent/risks and benefits

IC1

IC2

History

H1

Diagnostic considerations

D1

Definitions

Diagnosis of CGH

D2

Diagnosis of TTH

D3

D4

Examination

E1

Diagnostic imaging

DI1

General management considerations

G1

G2

Outcome assessment

O1

Considerations for frequency and duration of treatment

F1

F2

F3

CGH interventions

CGH1

CGH2

CGH3

CGH4

TTH interventions

TTH1

TTH2

TTH3

TTH4

Discussion

Strengths and limitations

Conclusions

Ethics Approval and Consent to Participate

Consent for Publication

Competing Interests

Authors’ Contributions

Footnotes

Acknowledgments

Author Disclosure Statement

Funding Information

Availability of Data and Materials

Supplemental Material