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Abstract

Background

Finger exercise is a mind-body practice rooted in Traditional Chinese Medicine (TCM), grounded in meridian and acupoint theory. It consists of coordinated finger and hand movements, massage, and pressure techniques that stimulate the flow of Qi and improve circulation, strengthen hand–brain connectivity, and cultivate mindfulness. Finger exercise is intended to promote physical health, enhance cognitive function, and support mental well-being.

Objective

To introduce the concept of finger exercise, synthesize emerging evidence on its effects on general, physical, cognitive, and mental well-being, and explore potential mechanisms and implications for research and practice. A preliminary framework was developed based on initial evidence.

Methods

We conducted a literature search of randominzed controlled trials across three English and two Chinese databases using search terms such as “finger exercise” combined with keywords related to health, cognition, depression, anxiety, and sleep. A total of 12 studies published in English or Chinese (with English abstracts) were included in this review.

Results

The reviewed studies reported varied intervention protocols incorporating TCM principles, brain-hand coordination, pressure techniques, and mindfulness-based strategies. Preliminary evidence suggests that finger exercise may improve general functioning (eg, ADL/IADL), physical indicators (eg, fatigue, sleep), cognitive performance, and mental health (eg, depression, anxiety). Potential mechanisms include enhanced Qi flow, neuroplasticity, neurotransmitter modulation, reduced inflammation, and improved mindfulness.

Conclusion

Mindfulness-based finger exercise shows promise as a low-cost, safe, and easily implemented non-pharmacological intervention that can be done standing or seated and is also suitable for individuals with disabilities or mobility limitations. It has a potential to be integrated into community centers, nursing homes, hospitals, and rehabilitation programs. Further research should confirm its benefits and clarify mechanisms.

Keywords

finger/hand exercise traditional Chinese medicine physical health cognitive health mental health

Finger exercise, or finger practice, is a Traditional Chinese Medicine (TCM)-based mind-body practice rooted in Qi (气) flow and the meridian system.^1-3 Finger exercise involves targeted rubbing, pressing, and tapping with all ten fingers and both hands, while emphasizing mindfulness to achieve balance. In TCM theory, fingers and hands are gateways to systemic health, as many meridians terminate or pass through the fingers, allowing stimulation of specific acupoints to regulate internal organ function. This integration of movement and mindfulness has the potential to promote both mental well-being⁴ and cognitive functions.⁵

The origins of finger exercise can be traced to ancient Chinese treatises on health, such as the Huangdi Neijing (黄帝内经, the Inner Canon of the Yellow Emperor).⁶ In this foundational work of TCM dated over 2000 years ago, it was noted that “The twelve meridians inwardly connect to the internal organs, and outwardly connect to the limbs and joints,” underscoring the connections among hands, meridians, and overall health. Additionally, hand movements are essential components of various traditional Qigong, including Wuqinxi (五禽戏, Five Animal Frolics)⁷ and Baduanjin (八段锦, Eight Pieces of Brocade).⁸ These exercises are grounded in the principles of balancing Qi and fostering harmony within the body.

Finger exercise typically involves stimulating acupoints on the fingers and hands, which are believed to regulate organ function, calm the mind, and enhance cognitive clarity. For example, Hegu (合谷, LI4) is traditionally used to relieve tension and improve Qi circulation,⁹ while Laogong (劳宫, PC8) is associated with calming the mind and reducing anxiety.¹⁰ These points illustrate how finger movements may influence physical, emotional, and cognitive states by activating key meridian pathways. These effects, long described in TCM, are also supported by biophysiological research evidence.

In this integrative/narrative review, we aim to introduce mindfulness-based finger exercise, synthesize existing evidence on its health effects, explore potential mechanisms, and outline research and practical implications. Key components of this framework are reflected in Figure 1, and will be detailed in the following sections.

Figure 1.

Conceptual Framework of Mindfulness-Based Finger Exercise for Health and Well-Being With Proposed Mechanisms.

Introduction to Finger Exercise

Finger exercise is a simple, low-risk mind-body practice rooted in TCM. This section introduces its theoretical foundation, core components, and the overview of the conceptual framework of finger exercise on health outcomes and associated mechanisms.

TCM Basis of Finger Exercise

Finger exercise is grounded in TCM theories of meridians, acupoints, and reflex zones, which connect to internal organs and physiological systems.¹¹ By stimulating specific regions on hands and fingers, individuals could gradually restore the balance of Qi (energy) and promote holistic health.¹² Notably, of the twelve principal meridians, six end on the hands (see Figure 2),¹³ linking to the lungs, heart, and intestines. Stimulating these pathways is believed to balance Yin-Yang (阴阳, the dynamic balance between opposing forces), and improve health. As an example, fMRI studies suggest Hegu (合谷, LI4) modulates brain networks for pain and cognition,¹⁴ while Laogong (劳宫, PC8) appears to influence autonomic and emotional regulation.¹⁰ Figure 2 illustrates key meridians and acupoints on hands relevant to practice.

Figure 2.

Key Meridians and Acupoints on Hands and Fingers. LU: Taiyin Lung Channel of Hand (手太阴肺经). PC: Jueyin Pericardium Channel of Hand (手厥阴心包经). HT: Shaoyin Heart Channel of Hand (手少阴心经). SI: Taiyang Small Intestine Channel of Hand (手太阳小肠经). TH: Shaoyang Sanjiao Channel of Hand (手少阳三焦经). LI: Yangming Large Intestine Channel of Hand (手阳明大肠经). These Acupoints – such as Hegu (合谷, LI4), Laogong (劳宫, PC8), Neiguan (内关, PC6), Shenmen (神门, HT7), and Shaochong (少冲, HT9) – are Commonly Used in Finger Exercise and are Believed to Regulate Qi Flow, Support Organ Function, and Promote Physical and Mental Well-Being Based on TCM Theory. Figure Extracted and Adapted from Online Website: The Exact Location of the Meridians on Hands and Fingers (Dr Peizhi Ye)

Overview of the Conceptual Framework of Mindfulness-Based Finger Exercise on Health Outcomes and Associated Mechanisms

Currently, there is no developed theoretical framework or standardized set of movements of finger exercise (unlike Wuqinxi or Baduanjin), although it has been practiced for centuries and has gained renewed attention in recent years as a low-impact, accessible mind-body practice. While the current evidence is limited, we here propose a preliminary framework (Figure 1) upon an integrative synthesis of TCM principles and emerging biomedical evidence. Figure 1 conceptualizes finger exercise as a multi-component intervention, with health effects hypothesized to occur through both TCM-based processes and biophysiological mechanisms.

The left section of Figure 1 highlights four interrelated components of finger exercise: (1) acupoint stimulation, (2) hand-brain coordination movements, (3) stretching and relaxation techniques, and (4) mindfulness and focused attention. Acupoint stimulation techniques include acupressure, massage, or gentle rhythmic tapping of key hand/finger points,^15,16 to regulate Qi flow and promote systemic balance. Hand-brain coordination movements use patterned finger moves to engage both hemispheres of the brain and support cognitive function,^17,18 to enhance attention, memory, and executive function. Stretching and relaxation movements reduce muscular tension, promote finger and hand dexterity and flexibility, support musculoskeletal and mental relaxation.¹⁹ Mindfulness and focused attention support present-moment awareness of movements and sensations, thus helping with attentional control, emotional stability, and stress regulation.²⁰ Notably, mindfulness functions both as a component of finger exercise and also a mechanism for enhancing attention, bodily awareness, and emotional regulation.

The central section of the framework depicts two interconnected categories of mechanisms. The first, Qi flow, meridian regulation, and mindfulness, reflects TCM-based theories, and the second, biophysiological mechanisms, includes pathways supported by biomedical evidence. Together, these mechanisms are hypothesized to contribute to the right section of the framework, which is the general, physical, cognitive, and mental health outcomes. Subsequent sections of this paper will elaborate on mechanisms and health outcomes, along with the empirical evidence.

Finger Exercise and Health Outcomes

Although finger exercise has long been incorporated in health practices,³² scientific investigation into its health effects is relatively recent, with most empirical studies emerging over the past two decades. Current research has primarily focused on adults and older adults, with the majority of studies conducted in China and published in Chinese-language journals.³³ While a few studies have reported limited or inconclusive findings, most studies suggest finger exercise may serve as a promising non-pharmacological intervention to improve sleep,²⁵ chronic pain,²⁶ depression,²⁸ cognitive function,^3,21,22 and overall health.^{22,23,25,27,28,30} The following sections review the current evidence of finger exercise’s health effects, organized by four domains: general, physical, cognitive, and mental health. Brief explanations of underlying mechanisms are also discussed.

To identify empirical intervetion studies on finger exercise and health outcomes, a search was conducted across five databases (PubMed, Cochrane Library, PsycINFO, Wanfang, and CNKI) from inception to February 2024. Eligible studies were randomized controlled trials involving middle-aged or older adults and reporting outcomes in at least one prespecified health domain (general, physical, cognitive, or mental health). Characteristics of included studies are summarized in Table 1. Full details of the search strategy, inclusion/exclusion criteria, and quality assessment procedures (also in Supplemental Table) are provided in the Supplementary Material.

Table 1.

Summary of included studies detailing sample characteristics, intervention features, and outcome measures

Reference	Participants	Sample size (I/C)	Age (mean(SD))	Intervention	Control	Daily interval, frequency	Duration	Instruments/health domains
Chen, 2016²¹	MCI patients	65 (32/33)	68.49 ± 5.27	Finger exercise	Health education	60 min, 2 days/week	3 months	MMSE: Cognition
Chen, 2016²¹	MCI patients	65 (32/33)	68.49 ± 5.27	Finger exercise	Health education	60 min, 2 days/week	3 months	FAQ: General health
Xue, 2019²²	MCI patients	69 (35/34)	71.40 ± 8.69; 72.97 ± 7.36	Finger exercise	Health education	10 min, 3 times/day	6 months	MoCA, MMSE, MES: Cognition
								FS-14: Fatigue
								EQ-5D, ADL, FAQ: General health
Qu et al, 2012²³	Mild AD patients	60 (30/30)	55∼90	Finger exercise	Free uninstructed finger exercise	45 min/day	6 months	ADL: General health
Wang, 2016²⁴	AD patients	45 (21/24)	73.57 ± 9.77; 73.46 ± 8.83	Finger exercise and Donepezil	Donepezil	≥20 min/day, ≥3 days/week	12 months	MMSE, MoCA: Cognition
Wang, 2016²⁴	AD patients	45 (21/24)	73.57 ± 9.77; 73.46 ± 8.83	Finger exercise and Donepezil	Donepezil	≥20 min/day, ≥3 days/week	12 months	ADL: General health
Zhang & Lin, 2022²⁵	AD patients	60 (20/20/20)	/	Five elements music finger exercise with personalized care	Personalized care; Regular care	10 min, 2 times/day	6 months	MMSE: Cognition
								ADL: General health
								PSQI: Sleep
								24-HAMD: Mental health
Zhang, 2023²⁶	Elderly patients with gouty arthritis	62 (31/31)	69.75 ± 2.46; 69.34 ± 2.77	Finger exercise	Regular care	2 times/day	4 weeks	VAS: Pain
						At least 10 days/week		SF-36: Physical health, pain, energy/Fatigue, mental health, general health
						At least 10 days/week		ADL: General health
Zhang et al, 2017²⁷	AD patients	200 (50/50; 50/50)	79.64 ± 6.08; 75.79 ± 6.84; 78.21 ± 6.24; 77.43 ± 6.56	Finger exercise; Combined	Control; Buyang Huanwu tang	∼75 min, 2 times/day	3 months	HDS, ADAS-cog: Cognition
Zhang et al, 2017²⁷	AD patients	200 (50/50; 50/50)	79.64 ± 6.08; 75.79 ± 6.84; 78.21 ± 6.24; 77.43 ± 6.56	Finger exercise; Combined	Control; Buyang Huanwu tang	∼75 min, 2 times/day	3 months	ADL: General health
Zhang et al, 2016²⁸	Mild senile dementia patients	120 (60/60)	70.4 (65∼82); 69.3 (65∼83)	Finger exercise and Donepezil	Donepezil	≥15 min/day	6 months	MMSE, MoCA: Cognition
Zhang et al, 2016²⁸	Mild senile dementia patients	120 (60/60)	70.4 (65∼82); 69.3 (65∼83)	Finger exercise and Donepezil	Donepezil	≥15 min/day	6 months	ADL: General health
Liu et al, 2016²⁹	Senile dementia patients	36 (18/18)	80.72 ± 7.291; 79.72 ± 9.430	Passive finger exercise	Regular care	25 min/day	3 months	MMSE: Cognition
								ADL: General health
								NPI: Mental health
Li et al, 2021³⁰	CIS patients	200 (100/100)	63.3 ± 5.7; 64.2 ± 5.0	Finger exercise	Routine care	∼60 min, 2 times/day	3 months	MoCA, MMSE, NIHSS, VCI: Cognition
Li et al, 2021³⁰	CIS patients	200 (100/100)	63.3 ± 5.7; 64.2 ± 5.0	Finger exercise	Routine care	∼60 min, 2 times/day	3 months	ADL: General health
Wang et al, 2022³	MCI patients	232 (117/115)	67.97 ± 6.32; 67.95 ± 6.80	Finger exercise	Control	30 min, 2 times/day	1 month	MMSE: Cognition
*Liao et al, 2025³¹	Community older adults	284 (142/142)	67.8 ± 5.7	Finger exercise	Control	20 min, 2 times/day	2 months	PHQ-9: Mental health
*Liao et al, 2025³¹	Community older adults	284 (142/142)	67.8 ± 5.7	Finger exercise	Control	20 min, 2 times/day	2 months	WHOQOL-BREF: General health

Notes. I, intervention; C, control; SD, standard deviation; MCI, mild cognitive impairment; AD, Alzheimer’s Disease; CIS, cerebral ischemic stroke; SF-36, the short form (36) health survey; MMSE, mini-mental state examination; MoCA, montreal cognitive assessment; ADL, activity of daily living; NPI, neuropsychiatric inventory; FAQ, functional activities questionnaire; VAS, visual analogue Scale; MES, memory and executive screening; EQ-5D, european quality of 5 dimensions; FS-14, fatigue scale-14; PSQI, pittsburgh sleep quality index; 24-HAMD, hamilton depression rating scale; HDS, hasegawa dementia scale; ADAS-cog, Alzheimer Disease assessment scale-cognitive section; NIHSS, neurologic functional defect; VCI, incidence of mild vascular cognitive impairment; PHQ-9, patient health questionnaire; WHOQOL-BREF, world health organization quality-of-life scale. Weekly intervention frequency being 7 days/week if not specified. *All studies were searched until February 2024, except the Liao et al, 2025 study.

General Health Outcomes and Daily Function

Many studies examining finger exercise have included measures of overall well-being, focusing on participants’ abilities to perform daily functional tasks, such as bathing, dressing, feeding, transferring, and toileting. A recent systematic review and meta-analysis³³ reported finger exercise interventions may lead to improvements in activities of daily living (ADL) in older adults with mild cognitive impairment (MCI) or Alzheimer’s disease (AD). This meta-analysis synthesized data from eight studies involving 770 participants,^22-25,27-30 of which six studies demonstrated significant improvements in ADL^{22,23,25,27,28,30} while two did not observe statistically significant results.^24,29 Several studies also evaluated instrumental activities of daily living (IADLs), such as food preparation, housekeeping, laundry, shopping, managing medications and finances, and using transportation. For instance, Xue et al.²² found that the finger exercise intervention group showed a 4.79% improvement in ADL score, a 19.52%, improvement in functional activities such as gaming, social visits, and memory tasks, and a 17.79% improvement in quality of life scores. Similarly, Chen et al.²¹ observed enhanced performance in functional activities after the finger exercise intervention. Qu et al.²³ also found improvements in both ADL and IADL scores post-intervention. Although Liu et al.²⁹ did not observe significant changes in overall ADL scores, they did report improvements in specific domains such as urinary control. Importantly, while the majority of evidence comes from cognitively impaired populations, one study also noted ADL improvements among older adults with arthritis.²⁶ Finally, in a most recent study where community older adults participated in 20-min, twice daily finger exercise intervention for two months, the quality of life scores of the intervention group were significantly improved.³¹ Importantly, they also found the number of falls significantly reduced, and balance and gait enhanced. A summary of findings related to general health outcomes, including ADL and IADL measures, is provided in Table 2.

Table 2.

Summary of Findings on General Health

Reference	Instrument	Key Findings
Chen, 2016²¹	FAQ	Participants in the experimental group showed significant improvements in functional activity compared to the control group post-intervention (t = 2.974, P = .004)
Xue, 2019²²	ADL	Significant group-by-time interaction were observed in abilities to perform daily activities and functional activities. For all three instruments, there were significant differences between groups post-intervention, with the intervention group showed 4.79%, 19.52%, and 17.79% improvements in ADL, FAQ, and EQ-5D, respectively
	FAQ
	EQ-5D
Qu et al, 2012²³	ADL	The intervention group showed significant improvements compared to the control group post-intervention (P < 0.05)
Wang, 2016²⁴	ADL	No significant differences exist across two groups
Zhang & Lin, 2022²⁵	ADL	There were no differences between the two groups at baseline and after 1-month intervention. After 3-month and 6-month’s intervention, the finger exercise group showed significantly improved independence in performing daily activities
Zhang, 2023²⁶	SF-36	With similar baseline level, the intervention group showed significantly better general health and abilities to perform daily activities compared to the control group post-intervention
Zhang, 2023²⁶	ADL
Zhang et al, 2017²⁷	ADL	Finger exercise intervention groups showed significantly improved daily activity abilities compared to baseline and to corresponding control groups after intervention
Zhang et al, 2016²⁸	ADL	The intervention group exhibited significantly improved ability in performing daily activities compared to the baseline level and the control group after 6 months’ finger exercise intervention
Liu et al, 2016²⁹	ADL	The total score in self-care ability were significantly improved post-intervention in the intervention group, whereas the control group experienced significant decreases
Li et al, 2021³⁰	ADL	Self-care ability significantly improved in the intervention group compared to baseline and that of the control group post-intervention
Liao et al, 2025³¹	WHOQOL-BREF	Quality of life significantly improved in the intervention group in all domains as compared to the control group, except for environmental health. Number of falls was reduced, and balance and gait were improved.

Several factors may contribute to the different effects of finger exercise on ADL, with age emerging as a potential moderator. Some evidence suggests the effectiveness of finger exercise may decline with advancing age.^29,30 This trend aligns with broader findings in cognitive training literature, where older adults were sometimes shown to benefit less from interventions compared to younger individuals.³⁴ However, some other studies reported older adults may still achieve meaningful gains.³⁵ In the context of finger exercise, the reduced benefits with increasing age could be attributed to declines in physical functioning and cognitive plasticity,³⁶ making it more challenging to perform intricate finger movements with high precision.

Potential Mechanisms

The improvement in ADL and IADL could be attributed to several potential mechanisms. For example, acupoint stimulation is believed to regulate internal organ systems. Stimulating acupoints such as Laogong (劳宫, PC8) and Hegu (合谷, LI4) may enhance Qi flow, promote systemic balance, and improve physiological functions relevant to daily activities such as continence and digestion.^37,38

Another important mechanism is the enhancement of motor skills and hand function. The combination of repeated finger movements, hand-eye coordination tasks, and massaging/stretching techniques has been associated with improvements in joint flexibility, coordination, and functional mobility. These movements stimulate neural pathways and brain regions associated with motor control,³⁹ executive function, and coordination, promoting inter-hemispheric connectivity and overall neural function.⁴⁰ This, in turn, could support better ADL performance. As an example, massaging the thumb during the finger exercise has been proposed to stimulate brain areas responsible for continence control, which is a key component of ADL.⁴¹

Overall, these mechanisms may contribute to improvements in physical function, energy balance, and overall well-being, highlighting the potential role of finger exercise in enhancing ADL and IADL performance.¹

Physical Health Outcomes

While some previous studies have demonstrated that finger exercise improves hand-specific functions like grip strength and post-surgical recovery, this review focuses more on its broader physical health effects, particularly related to fatigue, sleep, and joint pain. Fatigue has been one of the more frequently reported outcomes in finger exercise research. In a 6-month RCT,²² older adults with MCI who engaged in a structured 5-min finger exercise were found to experience significant reductions in self-reported fatigue. The intervention involved 14 movements, including palm massage, finger grasping, finger math calculation, acupoint stimulation on Hegu (合谷, LI4), Houxi (后溪, SI3), Shenmen (神门, HT7), Daling (大陵, PC7), and Taiyuan (太渊, LU9), and relaxation/hand-shaking movements. Similarly, Zhang²⁶ reported reductions in fatigue in a 4-week study among older adults with gouty arthritis, using a protocol that included massage, tapping, wrist relaxation, and acupoint activation. Sleep quality also appears to benefit in some cases from finger exercise. Zhang & Lin²⁵ studied the effect of five elements music finger exercise on hospitalized AD patients in various health domains. Participants reported improved sleep quality and fewer disturbances 3- and 6-month post-intervention, although no effects were seen at 1 month, suggesting benefits for sleep may require longer durations. Joint pain and general physical functioning were also examined in Zhang’s study,²⁶ which found reductions in joint discomfort and improvements in general physical functioning after the short 4-week intervention. Although the intervention duration was short, the protocol was comprehensive, and the result suggests that even brief engagement in finger exercise may be beneficial in managing physical symptoms. However, the study did not investigate long-term effects, and additional research is needed to evaluate the health benefits over time.

Despite the promising findings, the literature remains inconsistent. While some studies report significant improvements in physical health, others have found only marginally significant effects.²² Additionally, some improvements in sleep disturbances were not observed shortly after the intervention began but only emerged after a longer period of time.²⁵ This indicates the effects of finger exercise on sleep outcomes may require a longer duration to manifest, as compared to more immediate outcomes like joint pain. Overall, despite growing attention to non-pharmacological approaches for improving sleep and fatigue, relatively few studies have examined the effects of finger exercise in this area. Further research is needed to clarify long-term physical health benefits of finger exercise, and identify optimal intervention protocols. Table 3 summarizes key findings on physical health outcomes associated with finger exercise.

Table 3.

Summary of Findings on Physical Health

Reference	Domain	Instrument	Key Findings
Xue, 2019²²	Fatigue	FS-14	A marginal significant group x time interaction was identified. The intervention group showed significant reduced fatigue level across intervention, while the control group exhibited no significant difference
Zhang & Lin, 2022²⁵	Sleep	PSQI	There were no differences between the two groups at baseline and after 1-month intervention. After 3-month and 6-month’s intervention, the finger exercise group showed significantly less sleep disturbances
Zhang, 2023²⁶	Pain	VAS	With similar baseline level, the intervention group showed significantly lower joint pain compared to the control group post-intervention
Zhang, 2023²⁶	General	SF-36	With similar baseline level, the intervention group showed significantly better physical functioning and physical role functioning compared to the control group post-intervention

Potential Mechanisms

Finger exercise movements, particularly those involving meridian-based techniques and acupoint stimulation, are hypothesized to improve physical health through several mechanisms. First, the stimulation of acupoints such as Hegu (合谷, LI4), Daling (大陵, PC7), and Shaochong (少冲, HT9) is believed to enhance blood circulation and flow to the hands, upper limbs, and upper body,^42,43 reducing muscular stiffness, and support recovery in aging populations. These acupoints are frequently incorporated into finger exercise protocols.²²

Additionally, finger exercise may alleviate fatigue by modulating immune responses, leading to reduced levels of inflammation markers such as C-reactive protein (CRP) and improved physical functioning. For instance, a study found that inflammatory factors including IL-6 and hs-CRP were reduced after acupoint stimulation of Hegu (合谷, LI4) and Neiguan (内关, PC6),⁴⁴ suggesting a systemic anti-inflammatory effect.

Furthermore, acupressure on Hegu (合谷, LI4) and Shenmen (神门, HT7) was found to improve sleep quality and reduce insomnia symptoms, as well as alleviate fatigue,^45,46 potentially through modulation of inflammatory pathways and activation of the parasympathetic nervous system.

Collectively, these findings suggest potential pathways (circulatory, anti-inflammatory, and neuroregulatory) through which finger exercise might contribute to improved physical health outcomes such as fatigue, pain, and sleep disturbance.

Cognitive Health Outcomes

Although investigations on the health outcomes of finger exercise are overall limited, cognitive health has been the most extensively studied, with emerging but mixed evidence suggesting its potential benefits, particularly among individuals with MCI or early-stage AD.³³ Most studies have used validated tools such as the Montreal Cognitive Assessment (MoCA) and the Mini-Mental State Examination (MMSE).^47,48 Evidence in MCI populations has been generally more consistent than AD patients. Among older adults with MCI in China,^3,21,22 significant improvements in MoCA or MMSE scores were consistently reported after 1-6 months of finger exercise intervention, which included hand/finger massage, stretching, finger math, and stimulation of acupoints such as Neiguan (内关, PC6), Waiguan (外关, SJ5), Hegu (合谷, LI4), Houxi (后溪, SI3), and Laogong (劳宫, PC8).

However, findings in AD populations, especially those at moderate to severe stages, have been more mixed,³³ and disease severity appears to play a regulatory role that warrants further discussion. Zhang et al.²⁸ studied mild-stage AD patients practicing a 4-section finger exercise involving grasping, ordered movements, and object manipulation for 6 months, reporting significant cognitive improvements. In another study, MMSE cognition score was also significantly improved in the finger exercise group both 3 months and 6 months post-intervention.²⁵ Similarly, a study²⁷ with 200 AD patients compared groups receiving basic care, TCM treatment, or finger exercise with acupoint stimulation, and reported significantly better cognitive performance measured by the Hasegawa Dementia Scale (HDS) and Alzheimer Disease Assessment Scale-Cognitive Section (ADAS-cog) in groups involving finger exercise. However, not all studies in AD populations found strong and positive effects. Liu et al.²⁹ studied mostly moderate-stage (77.8%) AD patients using an 8-section passive finger exercise routine over 3 months. While some MMSE subscale improvements (recall, language) were observed, total MMSE differences were only marginally significant. Furthermore, Wang,²⁴ who included both mild and moderate AD patients, found no significant between-group cognitive differences after a 12-month intervention. These findings suggest that finger exercise may be less effective in more advanced stages of AD, where neurodegeneration may limit neuroplasticity; instead, it may be more helpful for individuals with milder levels of cognitive decline. Table 4 summarizes the findings on cognition associated with finger exercise.

Table 4.

Summary of Findings on Cognitive Health

Reference	Instrument	Key Findings
Chen, 2016²¹	MMSE	Scores of MMSE, attention and calculation, and delayed recall in experimental group are significantly increased comparing to control group before and after intervention (P < .05)
Xue, 2019²²	MoCA	There were significant group X time interactions in MoCA, MMSE, and MES, with the intervention group showing better cognitive function compared to the control group at 3 months and 6 months post-intervention
	MMSE
	MES
Wang, 2016²⁴	MoCA	No significant differences exist across two groups
Wang, 2016²⁴	MMSE	No significant differences exist across two groups
Zhang & Lin, 2022²⁵	MMSE	There were no differences between the two groups at baseline and after 1-month intervention. After 3-month and 6-month’s intervention, the finger exercise group showed significantly better cognitive performance
Zhang et al, 2017²⁷	HDS	Finger exercise intervention groups showed significantly improved cognitive performance compared to baseline and to corresponding control groups after intervention
Zhang et al, 2017²⁷	ADAS-cog
Zhang et al, 2016²⁸	MMSE	The intervention group exhibited significantly improved cognitive performance compared to the baseline level and the control group after 6 months’ finger exercise intervention
Zhang et al, 2016²⁸	MoCA
Liu et al, 2016²⁹	MMSE	After intervention, the scores of intervention group were higher than control group in the ability of recall and language, which had significant difference in two groups (P < .05)
Li et al, 2021³⁰	MoCA, MMSE, NIHSS, VCI	The scores of all instruments were improved in the intervention group compared to baseline and that of the control group post-intervention
Wang et al, 2022³	MMSE	The cognitive function as indicated by MMSE score were improved significantly in the intervention group compared to the control group

Several factors may contribute to the mixed findings. First, the duration of the intervention could play a key role. In studies where significant cognitive improvements were not observed, the exercise duration may have been too short, thus insufficient to yield significant benefits.²⁴ Supporting this, a meta-regression analysis identified total exercise hours as a significant moderator, indicating better outcomes at longer exercise hours.³³ Second, the severity of cognitive impairment appears to moderate the effects; interventions tend to show more consistent benefits in MCI or mild dementia compared to moderate or severe AD. This stage-specific pattern is consistent with previous findings showing that patients with amnestic MCI benefit more from interventions than those with mild AD,^49,50 and studies in AD populations generally have more frequently reported mixed or limited efficacy.⁵¹ Third, the specific intervention protocols could influence outcomes. Protocols focusing solely on motor coordination and muscle stretching may be less effective than those also incorporating acupoint stimulation. Further research is needed to assess the effectiveness of different finger exercise components. Finally, intervention fidelity may have varied across studies. For instance, without direct supervision, participants may have performed movements incorrectly, reducing effectiveness. Despite these mixed findings, the current evidence provides preliminary support for the efficacy of finger exercise in improving cognitive function, particularly in MCI or mild dementia populations.^28,51 These findings highlight the importance of implementing early-stage interventions to slow cognitive decline.

Potential Mechanisms

Several mechanisms have been suggested to explain how finger exercise enhances cognitive function. First, repetitive and coordinated finger movements may enhance neural activity in areas involved in executive function, attention, and memory.⁵² Neuroimaging studies have shown that finger exercise can stimulate neuroplasticity and strengthen functional connectivity between sensorimotor regions and cognitive networks.^3,30,53

Second, finger exercise often incorporates focused attention and mindful engagement, requiring individuals to maintain concentration on finger sequences and sensations. This mindfulness component may improve attentional control and working memory.⁵⁴ Similar to practices like Tai Chi,⁵⁵ the attentional focus in finger exercise is thought to help improve cognitive health in aging populations.

Third, finger exercise may increase the production of brain-derived neurotrophic factor (BDNF), which promotes synaptic plasticity and supports cognitive performance such as learning and memory,⁵⁶ as evidenced by a recent RCT study reporting increased BDNF levels following a finger exercise intervention.³¹ Additionally, finger exercise may have anti-inflammatory effects that help mitigate neuroinflammation, a key contributor to cognitive decline.⁵⁷ These effects contribute to a better environment for neuronal function and cognitive processes.

Finally, from a TCM perspective, finger exercise activates acupoints linked to brain regions involved in cognition. For example, stimulation of Daling (大陵, PC7) and Neiguan (内关, PC6) increased connectivity of nodes located in brain areas associated with memory and language,^53,58 and Hegu (合谷, LI4) modulated resting-state brain networks in AD.⁵⁹ Animal studies further support cognitive benefits of finger and hand acupuncture.^56,60

Taken together, these findings suggest that finger exercise may enhance cognition through multiple pathways involving neuroplasticity, BDNF release, inflammation reduction, and acupoint-specific brain modulation, though further studies are needed to strengthen the evidence.

Mental Health Outcomes

Although research on the mental health effects of finger exercise remains limited, several studies have reported potentially promising findings, particularly in reducing symptoms of depression, anxiety, and broader neuropsychiatric disturbances. Depressive symptoms have been a focus in a few studies. Zhang et al.²⁸ assessed depression in AD patients using the Hamilton Depression Rating Scale (24-HAMD). After 3 and 6 months, the intervention group showed significantly lower depression scores. Supporting these findings, Zhang²⁶ demonstrated that participants who received a finger exercise intervention exhibited significant improvements in mental well-being and mental role functioning. This improvement could be attributed to the dual benefits of physical activity and cognitive stimulation offered by finger exercise, which may help enhance mood, increase self-efficacy, and foster a greater sense of control over one’s mental health. Neuropsychiatric symptoms have also shown improvement. In a 3-month finger exercise intervention,²⁹ significant reductions were observed in total Neuropsychiatric Inventory (NPI) scores as well as subscales for anxiety, disinhibition, and abnormal behavior in AD patients. Notably, in a recent study among 284 community older adults, the depressive symptoms were significantly reduced in the finger exercise intervention group.³¹ However, replication across diverse populations and study designs remains limited. Table 5 summarizes the findings on mental health outcomes associated with finger exercise.

Table 5.

Summary of Findings on Mental Health

Reference	Instrument	Key Findings
Zhang et al, 2016²⁸	24-HAMD	There were no differences between the two groups at baseline and after 1-month intervention. After 3-month and 6-month’s intervention, the finger exercise group showed significantly less depression compared with the control group
Zhang, 2023²⁶	SF-36	With similar baseline level, the intervention group showed significantly better mental functioning and mental role functioning compared to the control group post-intervention
Liu et al, 2016²⁹	NPI	After intervention, the behavioral and psychological symptoms, including anxiety, disinhibition and abnormal behavior were significantly different (P < .05) across groups
Liao et al, 2025³¹	PHQ-9	Depressive symptoms significantly improved in the finger exercise intervention group as compared to the control group

Like other health outcomes, intervention duration appears to be a key factor influencing mental health. Studies with shorter durations (eg, 1 month) tend to show less pronounced effects on mental health, whereas longer interventions (3-6 months) appear to generate more consistent improvements.²⁸ This underscores the importance of considering intervention length in designing interventions targeting mental health.

Potential Mechanisms

Several pathways may explain how finger exercise could potentially support mental health. Drawing from acupuncture research,⁶¹ one key mechanism involves neurotransmitter modulation. Finger exercise may stimulate the release of endorphins and neuropeptide Y (NPY), which help reduce pain, elevate mood, and relieve stress.⁶²

Inflammation reduction is another potential pathway. Stimulating acupoints such as Hegu (合谷, LI4) has been shown to regulate the kynurenine pathway, reduce inflammation and glutamate release, and improve depression-like behaviors.⁶³

From a TCM perspective, finger exercise may promote emotional stability by supporting liver function, which in TCM is linked to mood regulation. Acupoints like Hegu (合谷, LI4) and Shenmen (神门, HT7) are believed to facilitate Qi flow in liver-associated meridians. Supporting this link, studies have shown that individuals with liver disease are more likely to develop depressive symptoms.⁶⁴ However, this theoretical connection remains speculative and requires more empirical validation.

Finger exercise may also reduce sympathoadrenal system activity by promoting parasympathetic activation through mindful movement and acupoint stimulation, leading to lower stress hormone levels, thereby alleviating symptoms of anxiety.⁶⁵

Finally, mindfulness and attentional focus may further enhance mental health. Many finger exercise protocols require sustained attention to movement and sensation, fostering a mindfulness-like state associated with improved emotional regulation and reduced anxiety.⁶⁶ These effects parallel those observed in broader mindfulness-based practices.⁶⁷ Specific acupoints on hands and arms, such as Jianshi (间使, PC5) and Shenmen (神门, HT7), have also been linked to improved attention,⁶⁸ and mindfulness may enhance self-regulation by increasing awareness of emotional and bodily signals.⁶⁹

Collectively, these mechanisms suggest that finger exercise can enhance mental health through a combination of neurobiological, physiological, and psychological processes, and further rigorous studies are needed to confirm the pathways involved and assess the generalizability of findings.

Summary of Potential Mechanisms

Although the mechanisms of finger exercise are not fully established, evidence suggests shared pathways supporting physical, cognitive, and emotional benefits. These reflect an integration of Traditional Chinese Medicine (TCM), neurobiology, and psychological self-regulation, activated through acupoint stimulation, hand-brain coordination, and mindful stretching/relaxation movement.

Finger exercise may promote health through numerous TCM-related processes. First, improved Qi flow and meridian regulation are considered foundational. Acupoint stimulation is thought to restore Qi circulation, balance Yin-Yang, and support organ health, thereby promoting blood flow, organ function, and systemic balance.⁴²

Second, mindfulness and focused attention further support emotional and cognitive regulation. Many protocols emphasize focused attention on movement and sensation, fostering a mindfulness-like state that enhances emotional awareness and stability, which may further alleviate symptoms of anxiety and depression.

Finger exercise may also exert its effects through biophysiological pathways. First, inflammation and immune modulation may play a role. Stimulating points like Hegu (合谷, LI4) and Shenmen (神门, HT7) may reduce inflammation, as shown by decreased CRP and IL-6 levels,⁴⁴ supporting fatigue and chronic pain management. While these effects are supported by acupressure studies, and some studies have explored acupoints on other regions of the body that reduce inflammation,^70,71 more research is needed to confirm these outcomes specifically through finger and hand acupoints.

Second, neural activation and plasticity represent another key pathway. Finger exercise may enhance connectivity between motor and cognitive brain regions, partly through increased production of BDNF and other neurotrophic factors.^3,30,53 Evidence in this area is relatively strong; however, results are mixed among those with advanced cognitive decline.³³ The discrepancies may be attributed to the severity of cognitive impairment, exercise duration, and the specific components of finger exercise used.

Third, autonomic regulation and stress reduction are also implicated. Gentle, rhythmic ten finger movements may stimulate the parasympathetic nervous system, reduce cortisol levels,⁷² and ease anxiety and depressive symptoms.^61,65 While the evidence is promising, it remains limited, and further studies are needed to better understand these effects.

These interconnected mechanisms are summarized in Figure 1. Importantly, although Qi flow and meridian regulation originate from TCM theory, a growing number of studies suggest that acupoint stimulation may influence modern physiological pathways. For example, it may activate peripheral nerves that modulate BDNF⁷³ and reduce inflammatory cytokines,⁷⁴ which are linked to cognitive and emotional regulation. These parallels remain preliminary, and more research is needed to clarify how TCM-related and biomedical mechanisms intersect. By regulating Qi, inflammation, neural connectivity, stress, and mindfulness, finger exercise functions as a holistic, multi-system intervention. Further research using standardized protocols, biomarkers, and imaging techniques is needed to clarify these pathways and optimize implementation.

Implications

Research Implications: Gaps and Future Directions

This paper provides the first integrative/narrative review of mindfulness-based finger exercise theory, evidence, and implications for health and well-being. While findings indicate potential benefits across physical, cognitive, and mental health domains, several gaps remain. First, most existing studies were conducted in Chinese populations and published in Chinese-language journals, which limits generalizability. Future RCTs should include more diverse populations and examine a wider range of outcomes, including sleep quality, fatigue, and pain, where evidence remains preliminary.

Another gap lies in the lack of standardized protocols of mindfulness-based finger exercise. Unlike established practices such as Baduanjin or Wuqinxi, finger exercise has no unified set of movements, and existing protocols vary in duration, frequency, acupoint selection, and incorporation of cognitive or mindfulness elements. These inconsistencies may contribute to inconclusive findings, for example among individuals with Alzheimer’s Disease. Further research is needed to refine and standardize protocols, identify essential components, and develop evidence-based guidelines, including comparative evaluations with other non-pharmacological interventions such as Tai Chi.

Methodological quality is also a concern, as many studies showed relatively high risks of bias and lacking details on randomization, allocation concealment, and blinding. Control conditions were often limited to health education or usual care, increasing performance bias. Future studies should adopt rigorous designs with well-defined protocols to minimize bias and strengthen the reliability of findings.

Evidence on mechanisms is similarly limited. Much current understanding derives from acupuncture studies, since little direct evidence exits on finger movement or acupressure. Future research should use finger exercise interventions to explore underlying mechanisms, connecting TCM-based principles with biophysiological pathways such as inflammation, neuroplasticity, and autonomic regulation. Studies incorporating neurobiological and physiological measures, such as biomarkers (eg, cortisol, BDNF) and brain imaging (eg, fMRI), are particularly needed to clarify pathways.

Finally, all existing interventions were delivered in person. Digital platforms, including AI-based motion sensors and mobile apps, could improve adherence, scalability, and remote tracking and data collection, thus enhancing both feasibility and fidelity. Collectively, these directions can build stronger evidence for the integration of finger exercise into health promotion and clinical practice.

Regarding the limitations of this review, the literature search was restricted to English- and Chinese-language databases, which may have excluded studies published in other Asian languages. Future reviews should capture a broader body of medical literature published on finger exercise. Additionally, due to the limited available evidence on finger exercise, the present study adopts an integrative/narrative review approach. Future reviews should employ systematic methods (including meta-analyses) to quantitatively synthesize findings when more robust evidence becomes available.

Practical Implications

Mindfulness-based finger exercise/practice offers a potentially practical, low-cost, non-pharmacological approach that can be easily integrated into various healthcare and community settings. In hospitals and rehabilitation centers, it may serve as a complementary tool to support recovery and symptom management, especially for individuals with disabilities, limited mobility, and cognitive challenges. In nursing homes and community centers, staff can implement group programs in collaboration with health professionals, residents, and families. Our recent feasibility study with 116 ethnically diverse older adults in Philadelphia⁷⁵ showed that finger exercise was safe, easy to learn, and feasible even for those with mobility limitations.

Importantly, given that the review found intervention effects to be more pronounced in milder stages of cognitive decline, finger exercise may hold particular value as an early preventive strategy. Implementing such interventions before substantial neurodegeneration occurs may maximize potential benefits and help slow functional decline.

At home, finger exercise can be part of daily self-care routines. It is safe, requires no equipment, can be practiced seated, and empowers older adults to manage their health, promote independence, and improve quality of life.

Overall, finger exercise holds potential as a simple and scalable intervention, though further evidence is needed to confirm its effectiveness and generalizability across populations.

Conclusion

Mindfulness-based finger exercise is a simple, safe and non-pharmacological approach grounded in Traditional Chinese Medicine (TCM) principles that can be practiced standing or seated. It aligns with whole-person health and integrative medicine by integrating physical movement, acupoint stimulation, and mindful attention. Emerging evidence suggests potential benefits for physical function, cognitive performance, and emotional well-being, especially in older adults and individuals with chronic conditions, disabilities or limited mobility.

However, current evidence is limited by methodological constraints, including small sample sizes, short intervention durations, heterogeneous protocols, and a predominance of studies conducted in Chinese populations. Further research is needed to clarify underlying mechanisms, evaluate long-term outcomes, and test finger exercise’s applicability across diverse populations. As interest in integrative and preventive health grows, mindfulness-based finger exercise offers a promising, low-cost strategy that warrants greater scientific and clinical attention.

Supplemental Material

Supplemental Material - Finger Exercise for Health and Well-Being: Theory, Evidence, and Implications

Supplemental Material for Finger Exercise for Health and Well-Being: Theory, Evidence, and Implications by Jianghong Liu, Haoer Shi and Yi Yang in Global Advances in Integrative Medicine and Health

Footnotes

ORCID iD

Jianghong Liu

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

Declaration of Conflicting Interests

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Supplemental Material

Supplemental material for this article is available online.

References

Liu

Chen

Liu

Guo

. Effect of passive finger exercises on grip strength and the ability to perform activities of daily living for older people with dementia: a 12-week randomized controlled trial. Clin Interv Aging. 2018;13:2169-2177. doi:10.2147/CIA.S174756

Yuan

Liu

, et al. The comparative effectiveness of traditional Chinese medicine exercise therapies in elderly people with mild cognitive impairment: a systematic review and network meta-analysis. Front Neurol. 2022;13:775190. doi:10.3389/fneur.2022.775190

Wang

Xie

, et al. Finger exercise alleviates mild cognitive impairment of older persons: a community-based randomized trial. Geriatr Nurs. 2022;47:42-46. doi:10.1016/j.gerinurse.2022.06.014

Keng

Smoski

Robins

. Effects of mindfulness on psychological health: a review of empirical studies. Clin Psychol Rev. 2011;31(6):1041-1056. doi:10.1016/j.cpr.2011.04.006

Sevinc

Rusche

Wong

, et al. Mindfulness training improves cognition and strengthens intrinsic connectivity between the hippocampus and posteromedial cortex in healthy older adults. Front Aging Neurosci. 2021;13:702796. doi:10.3389/fnagi.2021.702796

Shaw

Aland

. Meridians under the skin. Eur J Orient Med. 2014;7(6):18-23.

Wang

Xiao

, et al. Wuqinxi exercise improves hand dexterity in patients with Parkinson’s disease. Evid Based Complement Alternat Med. 2020;2020:8352176. doi:10.1155/2020/8352176

Wang

J-Y

Guo

Tang

Meng

. Case-control study on regular Ba Duan Jin practice for patients with chronic neck pain. Int J Nurs Sci. 2014;1(4):360-366. doi:10.1016/j.ijnss.2014.10.006

Wen

Hao

Zheng

. Acupoints for tension-type headache: a literature study based on data mining technology. Evid Based Complement Alternat Med. 2021;2021:5567697. doi:10.1155/2021/5567697

10.

Kim

Lee

Son

C-G

. Anatomical exploration of the PC8 acupoint through cadaveric study: implications for median and ulnar nerve stimulation. Compl Ther Clin Pract. 2025;60:101993. doi:10.1016/j.ctcp.2025.101993

11.

Chen

Antochi

Barbilian

. Acupuncture and the retrospect of its modern research. Rom J Morphol Embryol. 2019;60(2):411-418.

12.

Huang

S-W

Wang

W-T

Yang

T-H

Liou

T-H

Chen

G-Y

Lin

L-F

. The balance effect of acupuncture therapy among stroke patients. J Alternative Compl Med. 2014;20(8):618-622.

13.

Lee

I-S

Ryu

Chae

. Oversimplifying the name of the 12 meridian channels. Integr Med Res. 2023;12(4):101002. doi:10.1016/j.imr.2023.101002

14.

Wang

Nie

, et al. Effect of acupuncture in mild cognitive impairment and alzheimer disease: a functional MRI study. PLoS One. 2012;7(8):e42730. doi:10.1371/journal.pone.0042730

15.

Matos

Machado

Monteiro

Greten

. Understanding traditional Chinese medicine therapeutics: an overview of the basics and clinical applications. Healthcare (Basel). 2021;9(3):257. doi:10.3390/healthcare9030257

16.

Lin

Y-C

Tung

. Acupuncture qi flow and points measurement. Acupuncture for Pain Management. 2014;153-158.

17.

Kwok

Lam

Wong

, et al. Effectiveness of coordination exercise in improving cognitive function in older adults: a prospective study. Clin Interv Aging. 2011;6:261-267. doi:10.2147/CIA.S19883

18.

Liou

W-C

Chan

Hong

C-T

, et al. Hand fine motor skill disability correlates with dementia severity. Arch Gerontol Geriatr. 2020;90:104168. doi:10.1016/j.archger.2020.104168

19.

Dewi

Nurani

Fatmala

Wahida

Budhiana

Arsyi

. The five finger relaxation techniques on pain and sleep quality in rhematic patients in sukabumi village, working area of the selabatu health center, sukabumi city. IJNHS. 2022;5(6):501-510. doi:10.35654/ijnhs.v5i6.650

20.

Clark

Schumann

Mostofsky

. Mindful movement and skilled attention. Front Hum Neurosci. 2015;9:297. doi:10.3389/fnhum.2015.00297

21.

Chen

. Effects of Finger Exercise on Cognitive and Social Function in Community- Dwelling Older Adults with Mild Cognitive Impairment. Master. Taishan Medical University; 2016.

22.

Xue

. The Construction Effect of Cognitive Intervention Model for Elderly Individuals with Mild Cognitive Impairment. Master. Yangzhou University; 2019.

23.

Zhang

Zhu

. Finger exercises can improve the activities of daily living in elderly patients with mild dementia. Shanghai Nurs. 2012;12(04):14-16.

24.

Wang

. Effect of Finger Exercises on Cognitive Funtion and Hippocampal Volume in Patients with Alzheimer’s Disease. Master. Zhejiang Chinese Medical University; 2016.

25.

Zhang

Lin

. Application of five elements music finger exercise combined with personalized nursing in patients with Alzheimer's disease. Jilin Med J. 2022;43(08):2252-2255.

26.

Zhang

C-h

. Impact of finger exercise and diet intervention on the rehabilitation of elderly patients with gouty arthritis. Chin J Mod Drug App. 2023;17(08):161-165.

27.

Zhang

Huang

. Observation of Buyang Huanwu Tang combined with finger exercise for alzheimer disease. J Chin Med. 2017;49(08):148-151.

28.

Zhang

Liu

. Nursing effect of finger exercises on mild senile dementia patients. J Baotou Med Coll. 2016;32(09):116-117.

29.

Liu

Chen

Liu

Guo

. Effect of the passive exercises of fingers for the senile dementia patients. Scientific Res Aging. 2016;4(11):70-79.

30.

Deng

Guo

Wang

. Nursing effects of finger exercise on cognitive function and others for cerebral ischemic stroke patients. Am J Transl Res. 2021;13(4):3759-3765.

31.

Liao

Feng

, et al. The impact of finger exercise on falls, balance, gait, quality of life, and depressive symptoms among community-dwelling older adults: a randomized controlled trial. The Journals of Gerontology: Series A. 2025;80(10):glaf170.

32.

Chadwick

. A review of the history of hand exercises in rheumatoid arthritis. Muscoskel Care. 2004;2(1):29-39.

33.

Liu

Shi

. Finger exercise effects on cognitive functions in elders with MCI/AD/dementia: a systematic review and meta-analysis of randomized controlled trials. Brain Behavior and Immunity Integrative. 2023;4:100034. doi:10.1016/j.bbii.2023.100034

34.

Wykes

Reeder

Landau

Matthiasson

Haworth

Hutchinson

. Does age matter? Effects of cognitive rehabilitation across the age span. Schizophr Res. 2009;113(2-3):252-258. doi:10.1016/j.schres.2009.05.025

35.

Shaw

Hosseini

SMH

. The effect of baseline performance and age on cognitive training improvements in older adults: a qualitative review. J Prev Alzheimers Dis. 2021;8(1):100-109. doi:10.14283/jpad.2020.55

36.

Navarro

Calero

. Cognitive plasticity in young-old adults and old-old adults and its relationship with successful aging. Geriatrics. 2018;3(4):76.

37.

Sun

Liu

Zhang

. Clinical acupoint selection for the treatment of functional constipation by massage and acupuncture based on smart medical big data analysis. J Healthc Eng. 2021;2021:9930412. doi:10.1155/2021/9930412

38.

Shen

Liu

Wang

Liu

Miao

. Evaluating the clinical application and effect of acupuncture therapy in anal function rehabilitation after low-tension rectal cancer surgery. World J Clin Cases. 2024;12(18):3476-3481. doi:10.12998/wjcc.v12.i18.3476

39.

Nyberg

Eriksson

Larsson

Marklund

. Learning by doing versus learning by thinking: an fMRI study of motor and mental training. Neuropsychologia. 2006;44(5):711-717.

40.

Eschmann

Heroux

Cheetham

Potts

Diong

. Thumb and finger movement is reduced after stroke: an observational study. PLoS One. 2019;14(6):e0217969.

41.

Wang

Kui

. Application of acupoint massage in nursing care of elderly patients with dementia. Yunnan J Trad Chin Med Mater Med. 2014;35:81-82.

42.

McCaffrey

Fowler

. Qigong practice: a pathway to health and healing. Holist Nurs Pract. 2003;17(2):110-116.

43.

Wang

Zhu

Zhou

. Effects of electroacupuncture stimulation of the wushu acupoints along the heart channel on brain-derive neurotrophic factor overexpression and angiogenesis in rats with acute myocardial ischemia. Tradit Med Res. 2024;9(4):19. doi:10.53388/TMR20231011001

44.

Liu

Yin

, et al. Effects of transcutaneous electrical acupoint stimulation on postoperative cognitive decline in elderly patients: a pilot study. Clin Interv Aging. 2021;16:757-765. doi:10.2147/cia.S309082

45.

Nordio

Romanelli

. Efficacy of wrists overnight compression (HT 7 point) on insomniacs: possible role of melatonin? Minerva Med. 2008;99(6):539-547.

46.

Shergis

Jackson

, et al. A systematic review of acupuncture for sleep quality in people with insomnia. Complement Ther Med. 2016;26:11-20. doi:10.1016/j.ctim.2016.02.007

47.

Nasreddine

Phillips

Bédirian

, et al. The Montreal cognitive assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc. 2005;53(4):695-699. doi:10.1111/j.1532-5415.2005.53221.x

48.

Tombaugh

McIntyre

. The mini-mental state examination: a comprehensive review. J Am Geriatr Soc. 1992;40(9):922-935. doi:10.1111/j.1532-5415.1992.tb01992.x

49.

Förster

Buschert

Teipel

, et al. Effects of a 6-month cognitive intervention on brain metabolism in patients with amnestic MCI and mild Alzheimer’s disease. J Alzheimers Dis. 2011;26(s3):337-348.

50.

Buschert

Bokde

Hampel

. Cognitive intervention in Alzheimer disease. Nat Rev Neurol. 2010;6(9):508-517.

51.

Oltra-Cucarella

Perez-Elvira

Espert

Sohn McCormick

. Are cognitive interventions effective in Alzheimer’s disease? A controlled meta-analysis of the effects of bias. Neuropsychology. 2016;30(5):631-652.

52.

Jang

Park

Cruz

. Structured finger movements May enhance cognitive as well as motor functions of the brain. European J Sci Res. Editors-in-Chief. 2013;98(3):373.

53.

Dai

Yin

. Cerebral cortex functional networks of magnetic stimulation at acupoints along the pericardium meridian. J Integr Neurosci. 2019;18(1):79-85.

54.

Moradi

Ghorbani

Pouladi

Caldwell

Bailey

. The effects of mindfulness on working memory: a systematic review and meta-analysis. bioRxiv. 2025. doi:10.1101/2025.03.21.644687

55.

Xie

Zhang

Huo

Fan

. Tai Chi Chuan exercise related change in brain function as assessed by functional near–infrared spectroscopy. Sci Rep. 2019;9(1):13198.

56.

Lee

Sur

B-J

Kwon

, et al. Acupuncture stimulation alleviates corticosterone induced impairments of spatial memory and cholinergic neurons in rats. Evid Based Complement Alternat Med. 2012;2012(1):670536.

57.

Lee

. Neuroprotective effect of acupuncture against single prolonged stress induced memory impairments and inflammation in rat brain via modulation of brain derived neurotrophic factor expression. Evid Based Complement Alternat Med. 2022;2022(1):4430484.

58.

X-T

Sun

Zhang

, et al. Effectiveness and safety of acupuncture for vascular cognitive impairment: a systematic review and meta-analysis. Front Aging Neurosci. 2021;13:692508.

59.

Zhang

Qin

, et al. Effect of acupuncture stimulation of hegu (LI4) and taichong (LR3) on the resting-state networks in Alzheimer’s disease: beyond the default mode network. Neural Plast. 2021;2021:8876873. doi:10.1155/2021/8876873

60.

Feng

. Influences of electro-acupuncture at related jing-well points in rats with vascular dementia. J Tradit Chin Med. 2012;32(2):238-242.

61.

Yin

Cui

Wang

. Mechanisms of acupuncture in treating depression: a review. Chin Med. 2025;20(1):29. doi:10.1186/s13020-025-01080-7

62.

Morales-Medina

Dumont

Quirion

. A possible role of neuropeptide Y in depression and stress. Brain Res. 2010;1314:194-205. doi:10.1016/j.brainres.2009.09.077

63.

Jiang

, et al. Electroacupuncture attenuates LPS-Induced depression-like behavior through kynurenine pathway. Front Behav Neurosci. 2023;16:1052032. doi:10.3389/fnbeh.2022.1052032

64.

Lee

Otgonsuren

Younoszai

Mir

Younossi

. Association of chronic liver disease with depression: a population-based study. Psychosomatics. 2013;54(1):52-59.

65.

Liu

Lee

Kosowicz

, et al. Targeting mental health: a scoping review of acupoints selection in acupressure for depression, anxiety, and stress. Brain Behavior and Immunity Integrative. 2025;10:100111. doi:10.1016/j.bbii.2025.100111

66.

Parmentier

García-Toro

García-Campayo

Yañez

Andrés

Gili

. Mindfulness and symptoms of depression and anxiety in the general population: the mediating roles of worry, rumination, reappraisal and suppression. Front Psychol. 2019;10:506.

67.

van Agteren

Iasiello

, et al. A systematic review and meta-analysis of psychological interventions to improve mental wellbeing. Nat Hum Behav. 2021;5(5):631-652.

68.

Chou

Chu

Lin

J-G

. Effects of electroacupuncture treatment on impaired cognition and quality of life in Taiwanese stroke patients. J Alternative Compl Med. 2009;15(10):1067-1073.

69.

Vago

Silbersweig

. Self-awareness, self-regulation, and self-transcendence (S-ART): a framework for understanding the neurobiological mechanisms of mindfulness. Front Hum Neurosci. 2012;6:296.

70.

Qing

Zhao

Lin

. [Effect of acupuncture on patients with cancer-related fatigue and serum levels of CRP, IL-6, TNF-α and sTNF-R1]. Zhongguo Zhen Jiu. 2020;40(5):505-509. doi:10.13703/j.0255-2930.20190423-k0002

71.

Abdulaziz

Tareq Mohamad

Saad El-Din

Abdel

ART

Osman

. Effect of neurogenic acupoint cupping on high sensitive C-reactive protein and pain perception in female chronic pelvic pain: a randomized controlled trial. J Musculoskelet Neuronal Interact. 2021;21(1):121-129.

72.

Lee

Park

Kim

. The effects of heat and massage application on autonomic nervous system. Yonsei Med J. 2011;52(6):982-989. doi:10.3349/ymj.2011.52.6.982

73.

Miao

Zhang

. Effect of acupuncture on BDNF signaling pathways in several nervous system diseases. Front Neurol. 2023;14:1248348. doi:10.3389/fneur.2023.1248348

74.

Guo

Gong

, et al. The anti-inflammatory actions and mechanisms of acupuncture from acupoint to target organs via Neuro-Immune regulation. J Inflamm Res. 2021;14:7191-7224. doi:10.2147/jir.S341581

75.

Liu

Yang

Shi

Sun

Feng

Finger Exercise Group . Developing and evaluating a mindfulness-based finger/hand exercise intervention for ethnically diverse older adults with and without disabilities: a feasibility study. Geriatr Nurs. 2024;56:148-158. doi:10.1016/j.gerinurse.2024.02.008

Supplementary Material

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Mindfulness-Based Finger Exercise for Health and Well-Being: Theory,Evidence,and Implications

Abstract

Background

Objective

Methods

Results

Conclusion

Keywords

Introduction to Finger Exercise

TCM Basis of Finger Exercise

Overview of the Conceptual Framework of Mindfulness-Based Finger Exercise on Health Outcomes and Associated Mechanisms

Finger Exercise and Health Outcomes

General Health Outcomes and Daily Function

Potential Mechanisms

Physical Health Outcomes

Potential Mechanisms

Cognitive Health Outcomes

Potential Mechanisms

Mental Health Outcomes

Potential Mechanisms

Summary of Potential Mechanisms

Implications

Research Implications: Gaps and Future Directions

Practical Implications

Conclusion

Supplemental Material

Supplemental Material - Finger Exercise for Health and Well-Being: Theory, Evidence, and Implications

Footnotes

ORCID iD

Funding

Declaration of Conflicting Interests

Supplemental Material

References

Supplementary Material