Photobiomodulation (PBM) can provide solutions for many medical conditions, as well as numerous wellness issues. The therapeutic indications for PBM devices are not always clearly defined, and there are no requirements for mandatory training for those administering treatment sessions. At a time when access to PBM is becoming more widespread (at home or in health or wellness centers), it seems important to discuss the indications for PBM treatments for wellness and health reasons. In this article, we discuss the boundaries between indications in the field of wellness and health, the potential economic impact of distinguishing between these two areas, and the conditions that must be met for treatments to be effective.
de FreitasLF, HamblinMR. Proposed mechanisms of photobiomodulation or low-level light therapy. IEEE J Sel Top Quantum Electron2016;22(3):7000417.
2.
SonY, LeeH, YuS, et al.Effects of photobiomodulation on multiple health outcomes: An umbrella review of randomized clinical trials. Syst Rev.2025;14(1):160.
3.
VaninAA, VerhagenE, BarbozaSD, CostaLOP, Leal-JuniorECP. Photobiomodulation therapy for the improvement of muscular performance and reduction of muscular fatigue associated with exercise in healthy people: A systematic review and meta-analysis. Lasers Med Sci.2018;33(1):181–214.
4.
de Medeiros QuirinoL, da Silva MendoncaTM, Martins da SilvaCH, Borges Martins da Silva ParoH. Impact of photobiomodulation on the quality of life of men and women with androgenetic alopecia. Cureus.2024;16(8):e66023.
5.
MotaLR, DuarteIDS, GalacheTR, et al.Photobiomodulation reduces periocular wrinkle volume by 30%: A randomized controlled trial. Photobiomodul Photomed Laser Surg.2023;41(2):48–56.
6.
ShurrabK, Wael AoidaN. Photobiomodulation therapy for enhanced wound and scar healing: Visual and statistical evaluation. Lasers Med Sci.2025;40(1):334.
7.
ShurrabK, AlzghayarJN. Low-level laser therapy for skin rejuvenation: A safe and effective solution baked by data and visual evidence. J Cosmet Dermatol.2024;23(10):3234–3240.
8.
RobijnsJ, CensabellaS, BulensP, MaesA, MebisJ. The use of low-level light therapy in supportive care for patients with breast cancer: Review of the literature. Lasers Med Sci.2017;32(1):229–242.
9.
PranandaAT, SyahputraRA. Photobiomodulation therapy in keloid management: A comprehensive review. Front Med (Lausanne).2025;12:1550662.
10.
Jana NetoFC, MartimbiancoALC, de MedeirosDV, et al.Cost analysis of photobiomodulation in tibia fracture in the Brazilian public health system. PLoS One2023;18(12):e0294290.
11.
SobralSS, da Silva BrandaoEH, de Barros GalloC, et al.Analysis of the psychopathological profile, quality of life, and cost-effectiveness of oral lichen planus patients treated with photobiomodulation. Clin Oral Investig.2022;26(1):719–728.
12.
Kauark-FontesE, Rodrigues-OliveiraL, EpsteinJB, et al.Cost-effectiveness of photobiomodulation therapy for the prevention and management of cancer treatment toxicities: A systematic review. Support Care Cancer.2021;29(6):2875–2884.
13.
RobijnsJ, NairRG, LodewijckxJ, et al.Photobiomodulation therapy in management of cancer therapy-induced side effects: WALT position paper 2022. Front Oncol.2022;12:927685.
14.
HamblinMR. Shining light on the head: Photobiomodulation for brain disorders. BBA Clin.2016;6:113–124.
15.
GodaertL, DrameM. Efficacy of photobiomodulation therapy in older adults: A systematic review. Biomedicines.2024;12(7):1409.
16.
GodaertL, DrameM, LemaireA. Transcranial photobiomodulation for the treatment of chemobrain: New perspectives from a pilot study. Support Care Cancer.2026;34(1):62.
17.
BensadounRJ, EpsteinJB, NairRG, World Association for Laser T. et al.; Safety and efficacy of photobiomodulation therapy in oncology: A systematic review. Cancer Med.2020;9(22):8279–8300.
18.
ShurrabK. Proposed guidelines for reporting parameters and procedures of high- and low-level laser therapy in medical research articles. Med Devices (Auckl).2025;18:495–505.
19.
GobbiA, de CarvalhoG, SapaloAT, de Jesus GuirroRR. Acute application of photobiomodulation does not bring important gains for the muscular performance and functionality of diabetic individuals. Lasers Med Sci.2021;36(5):995–1002.
