Phototherapy is among the oldest and most highly effective treatment modalities available for moderate-to-severe psoriasis. However, concern regarding the potential carcinogenic risk associated with ultraviolet B (UVB) phototherapy and/or psoralen with ultraviolet A (PUVA) has been expressed by both providers and patients. The purpose of this review is to assess the cutaneous malignancy risks of UVB phototherapy and/or PUVA in all skin types, including Caucasian and non-Caucasian patients. We searched the MEDLINE database for original research articles regarding the skin cancer risk of phototherapy. A total of 61 articles were included. In Caucasians, an increased risk of squamous cell carcinoma with PUVA therapy was reported after >250 sessions, whereas studies among non-Caucasians did not show any increased risk. There was no convincing evidence of increased skin cancer risk associated with UVB phototherapy among all skin types. In view of the continued validation of its safety, phototherapy remains a valuable treatment option for patients with moderate-to-severe psoriasis.
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