The International Psoriasis Council (IPC) is a global nonprofit organization dedicated to advancing psoriasis research and treatment by providing a forum for education, collaboration, and innovation among physicians, researchers, and other professionals interested in psoriasis. Each year, the IPC identifies the top papers in the field of psoriasis. They are reviewed here.
BesgenP., TrommlerP., VollmerS., PrinzJ.C.Ezrin, maspin, peroxiredoxin 2, and Hsp27: potential targets of a streptococcal-induced autoimmune response in psoriasis. J Immunol.2010; 184: 5392–402.
2.
SinghT.P., SchönM.P., WallbrechtK.8-methoxypsoralen plus ultraviolet A therapy acts via inhibition of the IL-23/Th17 axis and induction of Foxp3+ regulatory T cells involving CTLA4 signaling in a psoriasis-like skin disorder. J Immunol.2010; 184(12): 7257–67.
3.
GriffithsC.E., StroberB.E., van de KerkhofP.; ACCEPT Study Group. Comparison of ustekinumab and etanercept for moderate-to-severe psoriasis. N Engl J Med.2010; 362(2): 118–28.
4.
KagamiS., RizzoH.L., LeeJ.J., KoguchiY., BlauveltA.Circulating Th17, Th22, and Th1 cells are increased in psoriasis. J Invest Dermatol.2010; 130(5): 1373–83.
5.
SchonthalerH.B., HuggenbergerR., WculekS.K., DetmarM., WagnerE.F.Systemic anti-VEGF treatment strongly reduces skin inflammation in a mouse model of psoriasis. Proc Natl Acad Sci U S A.2009; 15: 106(50): 21264–9.
6.
ZabaL.C., Suárez-FariñasM., Fuentes-DuculanJ.Effective treatment of psoriasis with etanercept is linked to suppression of IL-17 signaling, not immediate response TNF genes. J Allergy Clin Immunol.2009; 124(5) 1022–10.e1–395.
7.
CarusoR., BottiE., SarraM.Involvement of interleukin-21 in the epidermal hyperplasia of psoriasis. Nat Med.2009; 15(9) 1013–5.
8.
FengB.J., SunL.D., Soltani-ArabshahiR.Multiple Loci within the major histocompatibility complex confer risk of psoriasis. PLoS Genet.2009; 5(8): e1000606.
9.
NairR.P., DuffinK.C., HelmsC.Collaborative association study of psoriasis. Genome wide scan reveals association of psoriasis with IL-23 and NF-kappa B pathways. Nat. Genet.2009; 41(2): 199–204.
10.
ZhangX.J., HuangW., YangS.Psoriasis genome-wide association study identifies susceptibility variants within the LCE gene cluster at 1q21. Nat. Genet.2009; 41(2): 205–10.
11.
GoodmanW.A., LevineA.D., MassariJ.V., SugiyamaH., McCormickT.S., CooperK.D.IL-6 signaling in psoriasis prevents immune suppression by regulatory T cells. J Immunol.2009; 183(5): 3170–6.
12.
MehtaN.N., AzfarR.S., ShinD.B., NeimannA.L., TroxelA.B., GelfandJ.M.Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J.2010; 31(8) 1000–6.
