Purpose: To report the successful repair of rhegmatogenous retinal detachments (RRD) associated with ocular toxoplasmosis using scleral buckling alone in 2 young patients. Methods: Two cases were retrospectively reviewed. Results: The first patient was a 16-year-old girl with recurrent toxoplasma retinochoroiditis who developed a macula-on inferior RRD 10 weeks after her most recent inflammatory flare. She underwent repair with a 41/70 scleral buckle, cryotherapy, and subretinal fluid (SRF) drainage. At 1 year postoperatively, the retina remained attached with stable visual acuity (VA). The second patient was a 39-year-old woman with ocular toxoplasmosis of uncertain flare frequency who presented with a superonasal macula-on RRD repaired, which was repaired with a 240/270 scleral buckle and a segmental 276 superonasal element, cryotherapy, SRF drainage, and 100% intravitreal perfluoropropane injection. At 1 year postoperatively, the retina remained attached, with favorable VA. Conclusions: Scleral buckling alone may lead to favorable anatomic and functional outcomes for selected cases of ocular toxoplasmosis-related RRD, even in the presence of active intraocular inflammation.