Purpose: To describe a case of bilateral peripheral neovascularization (NV) secondary to hemoglobin C trait. Method: A single case was evaluated. Results: A 74-year-old Black woman presented asymptomatically with peripheral nonperfusion and NV on examination and angiography during an anemia evaluation, which led to a diagnosis of hemoglobin C trait. Conclusions: Hemoglobin C trait is a rare but known cause of NV. This case highlights the importance of hemoglobinopathy screening in cases of peripheral NV, as these findings may indicate systemic disease and require a multidisciplinary approach.
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