Human Amniotic Membrane Patch for Optic Disc Pit Maculopathy Remains Integrated at 2 Years

Abstract

Purpose: To evaluate the efficacy of a human amniotic membrane patch to treat optic disc pit maculopathy. Methods: Three cases are presented. Results: Three patients with optic disc pit maculopathy were treated with pars plana vitrectomy and a human amniotic membrane patch of the optic disc pit. The primary outcomes were resolution of subretinal fluid (SRF) and intraretinal fluid, changes in best-corrected visual acuity (BCVA), and any postoperative complications. Complete resorption of SRF and substantial decreases in central retinal thickness were seen at follow-up. Significant improvements in VA and microperimetry correspond with a decline in retinal responsiveness related to the chronicity of maculopathy. No patient reported complications or recurrences, and the patch remained visible on optical coherence tomography for up to 26 months of follow-up. Conclusion: Anatomic and visual improvement was seen in all 3 patients. The human amniotic membrane patch is a safe and effective treatment for optic disc pit maculopathy.