Haplo-Storm induced acute kidney injury

Abstract

With the advancement in immunosuppressive management and graft versus host disease prophylaxis, hematopoietic stem cell transplantation from a haploidentical donor is increasingly used and has become a standard donor option for patients lacking an appropriately matched sibling or unrelated donor. Inflammatory cytokines released by activated lymphocytes and innate cells in the context of cellular therapy can cause fever, vasodilatation, and end-organ damage, collectively known as cytokine release syndrome, is a common complication in patients undergoing haploidentical stem cell transplant and in this setting referred as “haplostorm.” We present a case of acute kidney injury induced by haplostorm after receiving a haploidentical hematopoietic stem cell transplant. The patient was managed with tocilizumab and conservatively without the need for kidney replacement therapy. Over the course, the patient had a successful kidney recovery.