VargaJTrojanowskaMKuwanaM. Pathogenesis of systemic sclerosis: recent insights of molecular and cellular mechanisms and therapeutic opportunities. J Scleroderma Relat Disord2017; 2: 137–152.
2.
ElhaiMMeuneCBoubayaM, et al. Mapping and predicting mortality from systemic sclerosis. Ann Rheum Dis2017; 76(11): 1897–1905.
3.
FischerAZimovetzELingC, et al. Humanistic and cost burden of systemic sclerosis: a review of the literature. Autoimmun Rev2017; 16(11): 1147–1154.
4.
TashkinDPElashoffRClementsPJ, et al. Cyclo-phosphamide versus placebo in scleroderma lung disease. N Engl J Med2006; 354: 2655–2666.
5.
TashkinDPRothMDClementsPJ, et al. Mycophenolate mofetil versus oral cyclophosphamide in scleroderma-related interstitial lung disease (SLS II): a randomised controlled, double-blind, parallel group trial. Lancet Respir Med2016; 4: 708–719.
6.
Fernandez-CodinaAWalkerKMPopeJE. Treatment algorithms for systemic sclerosis according to experts. Arthritis Rheumatol2018; 70(11): 1820–1828.
7.
WollinLDistlerJHWDentonCP, et al. Rationale for the evaluation of nintedanib as a treatment for systemic sclerosis—associated interstitial lung disease. J Scleroderma Relat Disord2019; 4: 212–218.
8.
KuwanaMAzumaA. Nintedanib: new indication for systemic sclerosis-associated interstitial lung disease. Mod Rheumatol. Epub ahead of print 20 December 2019.
9.
DistlerOHighlandKBGahlemannM, et al. Nintedanib for systemic sclerosis-associated interstitial lung disease. N Engl J Med2019; 380: 2518–2528.
10.
Hoffmann-VoldAMMaherTMPhilpotEE, et al. Evidence-based European consensus statements for the identification and management of interstitial lung disease in systemic sclerosis. Lancet Rheumatol2020. Published: January 14, 2020 DOI: 10.1016/S2665-9913(19)30144-4.
11.
HerzogELMathurATagerAM, et al. Interstitial lung disease associated with systemic sclerosis and idiopathic pulmonary fibrosis: how similar and distinct?Arthritis Rheumatol2014; 66(8): 1967–1978.
12.
Idiopathic Pulmonary Fibrosis Clinical Research Network, RaghuGAnstromKJ, et al. Prednisone, azathioprine, and N-acetylcysteine for pulmonary fibrosis. N Engl J Med2012; 366: 1968–1977.
13.
ManADavidyockTFergusonLT, et al. Changes in forced vital capacity over time in systemic sclerosis: application of group-based trajectory modelling. Rheumatology2015; 54(8): 1464–1471.
14.
KuwanaMShiraiYTakeuchiT. Elevated serum Krebs von den Lungen-6 in early disease predicts subsequent deterioration of pulmonary function in patients with systemic sclerosis and interstitial lung disease. J Rheumatol2016; 43(10): 1825–1831.
15.
HuangJMaierCZhangY, et al. Nintedanib inhibits macrophage activation and ameliorates vascular and fibrotic manifestations in the Fra2 mouse model of systemic sclerosis. Ann Rheum Dis2017; 76(11): 1941–1948.