Abstract
Background
Coffee is one of the most popular beverages in the world. Most people drink a cup of coffee to start and wrap up their daily tasks. Bioactive compounds of coffee such as caffeine, diterpenes, and chlorogenic acids are known to stimulate physiological processes. Students also ingest coffee in an attempt to stay up late reading. We aimed to determine the effect of chronic consumption of coffee on complete blood count and liver histology in Wistar rats.
Methods
Wistar rats were divided into control Group 1, Group 2, Group 3, and Group 4 and were fed with water and feed, 100 mg/kg body weight, 200 mg kg/body weight, and 300 m/kg body weight of coffee, respectively, for 3 weeks. Blood samples were analyzed for hematological parameters, and liver tissues were histologically examined for structural changes.
Result
There was a dose-dependent increase in the body weight of coffee-treated animals. The hemoglobin, pack cell volume, and red blood cell count also significantly increased in animals administered with coffee compared to controls. However, chronic ingestion induces apoptotic changes in the liver.
Conclusion
Our data suggest that coffee has a positive effect on hematological indices. However, chronic consumption is injurious to the liver in rats.
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