Novel strategies for biofilm eradication – enzymes,nanoparticles,quorum sensing inhibitors,bioelectric effect,bio-acoustic effect,and antimicrobial photodynamic therapy

Abstract

Biofilms are communities of microorganisms resistant to conventional antibiotics, posing a major threat to medical as well as industrial settings. These ideas target the biofilm matrix, communication of bacteria, or increasing antibiotic susceptibility. These strategies offer a promising alternative or adjunct to traditional treatment by disrupting biofilm structure and bacterial behaviour. Combination of these methods with existing antibiotics may enhance efficiency against chronic interventional device-related infections, significantly advancing biofilm management and antimicrobial therapy. This communication enlightens the emerging strategies – enzymes, nanoparticle quorum sensing inhibitors, bioelectric effect, bio-acoustic effect, and antimicrobial photodynamic therapy as an innovative tool for biofilm disruption and eradication.