Abstract
Introduction and Objectives:
Articular cartilage injuries, caused by trauma, genetic predisposition, and degenerative changes, are characterized by limited self-repair abilities due to the absence of blood vessels and restricted progenitor cell entry. Osteoarthritis (OA) is a common condition, progressively eroding articular cartilage and impacting all joint tissues. Mesenchymal Stem Cells (MSCs) offer promising stem cell-based therapies for cartilage regeneration, with their secretome playing a vital role in tissue repair. MSC-derived exosomes have demonstrated beneficial effects in promoting cartilage regeneration and preventing degeneration. This review highlights the potential of MSCs in cell therapy for repairing articular cartilage defects and related issues.
Materials and Methods:
In this systematic review PubMed, MEDLINE, the Cochrane Library, Scopus, Web of Science, and Science Direct were searched up to 27 July 2023. The ARRIVE criteria were used to assess the risk of bias.
Results:
Of the 63 screened studies, based on the inclusion and exlusion criteria, 6 studies met the eligibility criteria to systematically reviewed. Theres a significance of synovial membrane-derived MSCs (SMMSCs) in cartilage repair due to their close relation to chondrocytes and enhanced chondrogenic potential. We also found specific microRNAs to enhance the effectiveness. To enhance the impact of MSC exosomes, we have explored methods for effectively retaining them at the cartilage defect site.
Conclusion:
It was demonstrate strong support for the promising potential of Stem Cells Conditioned Medium (Secretome) in facilitating knee cartilage healing.