Melanotic neuroectodermal tumour of infancy is an extremely rare neoplasm arising in newborns and young children, typically involving the face or cranium. A case arising from the maxilla, requiring extensive resection with a near-total maxillectomy, is presented. A thorough review of the literature on this unusual tumour is provided, with emphasis on prognostic factors and appropriate treatment.
KayaS., UnalO.F., SaracS., GedikogluG.. Melanotic neuroectodermal tumor of infancy: Report of two cases and review of literature.Int J Pediatr Otorhinolaryngol2000; 52: 169-72.
2.
FranchiG., SleilatiF., SoupreV.Melanotic neuroectodermal tumor of infancy involving the orbit and maxilla: Surgical management and follow-up strategy.Br J Plast Surg2002; 55: 526-9.
MorinS., BergevinM., DerkayC.. Melanotic neuroectodermal tumor of infancy (MNTI).Arch Otolaryngol Head Neck Surg1992; 118: 664-7.
5.
CarnevaleG.G., MortellitiA.J.. The operating microscope in the management of melanotic neuroectodermal tumor of infancy.Am J Otolaryngol2001; 22: 76-9.
6.
PuchalskiR., ShahU.K., CarpentieriD., McLaughlinR., HandlerS.D.. Melanotic neuroectodermal tumor of infancy (MNTI) of the hard palate: Presentation and management.Int J Pediatr Otorhinolaryngol2000; 53: 163-8.
7.
AntunesA.C., FreitasR.M., OliveiraP.P., ReboucasR.G.. Melanotic neuroectodermal tumor of infancy: Case report.Arq Neuropsiquiatr2005; 63: 670-2.
8.
TanO., AtikB., UgrasS.. Melanotic neuroectodermal tumor in a newborn.Int J Pediatr Otorhinolaryngol2005; 69: 1441-4.
AgarwalP., AgarwalV., RainaV.K.. Melanotic neuroectodermal tumor of infancy: Case report of an unusual tumor.Indian J Plastic Surg2003; 36: 123-5.
11.
EckardtA., SwennenG., TeltzrowT.. Melanotic neuroectodermal tumor of infancy involving the mandible: 7-year follow-up after hemimandibulectomy and costochondral graft reconstruction.J Craniofac Surg2001; 12: 349-54.
12.
Al-MarzooqY.M., Al-BagshiM.H., ChopraR., HashishH.. Melanotic neuroectodermal tumor of infancy in the soft tissues of the arm: Fine needle aspiration biopsy and histologic correlation-a case report.Diagn Cytopathol2003; 29: 352-5.
13.
IjiriR., OnumaK., IkedaM.Pigmented intraosseous odontogenic carcinoma of the maxilla: A pediatric case report and differential diagnosis.Hum Pathol2001; 32: 880-4.
14.
Gaiger de OliveiraM., ThompsonL.D., ChavesA.C., RadosP.V., da Silva LauxenI., FilhoM.S.. Management of melanotic neuroectodermal tumor of infancy.Ann Diagn Pathol2004; 8: 207-12.
15.
BarrettA.W., MorganM., RamsayA.D., FarthingP.M., NewmanL., SpeightP.M.. A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy.Oral Surg Oral Med Oral Pathol Oral Radiol Endod2002; 93: 688-98.
16.
LiuH.H., ChenT.W., ChangH.S.. Melanotic neuroectodermal tumor of infancy in the maxilla: A case report.Int J Paediatr Dent2004; 14: 371-5.
17.
HaiderN., Mc DermottM., FitzgeraldR.J.. Melanotic neuroectodermal tumor of infancy arising in skull.Med Pediatr Oncol2003; 41: 495-6.
18.
CutlerL.S., ChaudhryA.P., TopazianR.. Melanotic neuroectodermal tumor of infancy: An ultrastructural study, literature review, and reevaluationCancer1981; 48: 257-70.
19.
GuptaA., TrehanA., MarwahaR.K., SharmaR.K., NijhawanR.. Melanotic neuroectodermal tumor in an infant.Indian J Pediatr2002g;69:725-6.
20.
MastB.A., KapadiaS.B., YunisE., BentzM.. Subtotal maxillectomy for melanotic neuroectodermal tumor of infancy.Plast Reconstr Surg1999; 103: 1961-3.
21.
AtkinsonG.O.Jr, DavisP.C., PatrickL.E., WinnK.J., BallT.I., WylyJ.B.. Melanotic neuroectodermal tumor of infancy. MR findings and a review of the literature.Pediatr Radiol1989; 20: 20-2.
22.
NittaT., EndoT., TsunodaA., KadotaY., MatsumotoT., SatoK.. Melanotic neuroectodermal tumor of infancy: A molecular approach to diagnosis.J Neurosurg1995; 83: 145-8.
23.
GeorgeJ.C., EdwardsM.K., JakackiR.I., Kho-DuffinJ.. Melanotic neuroectodermal tumor of infancy.AJNR Am J Neuroradiol1995; 16: 1273-5.
24.
NishioS., MoriokaT., MurakamiN., FukuiM., InamitsuT., IshiharaS.. Melanotic neuroectodermal tumor of infancy at the anterior fontanelle.Neuroradiology1999; 41: 202-4.
Galera-RuizH., Gomez-AngelD., Vazquez-RamirezF.J., Sanguino-FabreJ.C., Salazar-FernandezC.I., Gonzalez-HacheroJ.. Fine needle aspiration in the preoperative diagnosis of melanotic neuroectodermal tumor of infancy.J Laryngol Otol1999; 113: 581-4.
27.
MetwalyH., ChengJ., MaruyamaS.Establishment and characterization of new cell lines derived from melanotic neuroectodermal tumor of infancy arising in the mandible.Pathol Int2005; 55: 331-42.
28.
RickertC.H., Probst-CousinS., BlasiusS., GullottaF.. Melanotic progonoma of the brain: A case report and review.Childs Nerv Syst1998; 14: 389-93.
LahavR., ZillerC., DupinE., Le DouarinN.M.. Endothelin 3 promotes neural crest cell proliferation and mediates a vast increase in melanocyte number in culture.Proc Natl Acad Sci USA1996; 93: 3892-7.
31.
StoneJ.G., SpirlingL.I., RichardsonM.K.. The neural cell population responding to endothelin-3 in vitro includes multipotent cells.J Cell Sci1997; 110: 1673-82.
32.
WatabeH., SomaY., KawaY.Differentiation of murine melanocyte precursors induced by 1,25-dihydroxyvitamin D3 is associated with the stimulation of endothelin B receptor expression.J Invest Dermatol2002; 119: 583-9.
33.
MoriuchiS., ShimizuK., MiyaoY., HayakawaT.. A novel PNET cell line with melanotic differentiation.Anticancer Res1996; 16: 779-84.
DashtiS.R., CohenM.L., CohenA.R.. Role of radical surgery for intracranial melanotic neuroectodermal tumor of infancy: case report.Neurosurgery1999; 45: 175-8.
MirichD.R., BlaserS.I., Harwood-NashD.C., ArmstrongD.C., BeckerL.E., PosnickJ.C.. Melanotic neuroectodermal tumor of infancy: Clinical, radiologic, and pathologic findings in five cases.AJNR Am J Neuroradiol1991; 12: 689-97.
40.
WoessmannW., NeugebauerM., GossenR., Blutters-SawatzkiR., ReiterA.. Successful chemotherapy for melanotic neuroectodermal tumor of infancy in a baby.Med Pediatr Oncol2003; 40: 198-9.
41.
JohnsonR.E., ScheithauerB.W., DahlinD.C.. Melanotic neuroectodermal tumor of infancy. A review of seven cases.Cancer1983; 52: 661-6.
42.
PettinatoG., ManivelJ.C., d'AmoreE.S., JaszczW., GorlinR.J.. Melanotic neuroectodermal tumor of infancy. A reexamination of a histogenetic problem based on immunohistochemical, flow cytometric, and ultrastructural study of 10 cases.Am J Surg Pathol1991; 15: 233-45.
43.
BlockJ.C., WaiteD.E., DehnerL.P., LeonardA.S., OgleR.G., GattoD.J.. Pigmented neuroectodermal tumor of infancy. An example of rarely expressed malignant behavior.Oral Surg Oral Med Oral Pathol1980; 49: 279-85.
44.
Navas PalaciosJ.J.. Malignant melanotic neuroectodermal tumor: Light and electron microscopic study.Cancer1980; 46: 529-36.
45.
van OijenM.G., MedemaR.H., SlootwegP.J., RijksenG.. Positivity of the proliferation marker Ki-67 in noncycling cells.Am J Clin Pathol1998; 110: 24-31.
