Leiomyosarcoma is a malignant tumour of mesenchymal origin that is uncommon in the head and neck, and particularly uncommon in the oral cavity. This article presents a case of primary leiomyosarcoma affecting the mucosal lining of the cheek in a 35-year-old woman. The need for wide excision is emphasized, and because of the high frequency of regional lymph node metastasis, an ipsilateral neck dissection is advocated, followed by adjuvant radiotherapy for residual microscopic disease.
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