Differences in lethality and diffusion of Covid-19 and different kinds of vaccines: Correspondence

Dear Editor, we would like to discuss “Differences in lethality and diffusion of Covid-19 in countries using different kinds of vaccines.” ¹ Carta et al. ¹ observed that the incidence of new cases was similar in countries with a high prevalence of mRNA vaccines and that the lethality of Sars-Cov2 was lower in those countries than in those with a high prevalence of viral vehicle vaccines but not in those with a high prevalence of inactivated vaccines. According to Carta et al., ¹ fewer infected people die in a given country when there is a higher vaccination rate per resident. The effectiveness of the COVID-19 immunization may be impacted by a number of factors. There are several dosages and administration methods available. Patients who utilize prescription medicines or have underlying medical issues may be more vulnerable to vaccinations than a typical, healthy vaccine receiver. We can all agree that giving the COVID-19 vaccine is a smart idea. It’s possible that the rather frequent precursor COVID-19 without symptoms is also involved. ²

In order to rule out a prior, asymptomatic COVID-19 infection, testing is typically skipped. It is possible to learn more about a person’s underlying immunological problems through routine blood tests. By regularly monitoring participants’ underlying immunological disorders, it is feasible to more accurately predict how the COVID-19 vaccination will perform. When assessing the effectiveness or safety of a vaccination, this is a crucial factor to take into account. Numerous studies have shown the efficacy, safety, or clinical significance of the COVID-19 vaccine, despite the fact that there is frequently little information available regarding pre-vaccination immunological or health status and the possibility of confounding with non-symptomatic SARS-Co-V2 infection cannot be effectively ruled out. Finally, the recent study revealed that vaccine recipients’ background genetic polymorphism is also connected to their immunological response to COVID-19. ³ Therefore, consideration should be given to the effects of the genetic polymorphism if additional research is planned. In order to effectively stop the spread of COVID-19, it should also emphasize how important it is to incorporate prevention and protection measures in addition to vaccination. ⁴