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Abstract

Study Design:

Retrospective cohort study.

Objective:

To determine the effects of operative time on postoperative complications in patients age 65 and older undergoing posterior lumbar fusion.

Methods:

All patients age 65 and older undergoing posterior lumbar fusion were identified in the 2012 to 2015 American College of Surgeons National Surgical Quality Improvement Program database. The primary outcome measures were complications occurring up to 30 days postoperatively, including death, any complication, and complication subtypes. The primary independent variable was operative duration. Both bivariate and multivariate analyses utilized logistic regression and analyzed operative duration as a continuous variable. Statistical significance was considered P < .05.

Results:

A total of 4947 patients age 65 and older undergoing posterior lumbar fusion were identified. The mean operative time was 3.3 hours (SD 1.7). The overall complication rate was 13.4% (n = 665). In multivariate analysis, each incremental hour of operative time was associated with increased risk of postoperative thromboembolism (odds ratio [OR] = 1.23; 95% confidence interval [CI] = 1.10-1.37), transfusion (OR= 1.25; 95% CI = 1.18-1.32), urinary tract infection (OR = 1.21; 95% CI = 1.10-1.32), and total postoperative complications (OR = 1.22; 95% CI = 1.16-1.27).

Conclusion:

For patients age 65 and older undergoing posterior lumbar fusion, longer operative time is associated with greater risk for thromboembolism, transfusion, intubation, kidney injury, urinary tract infection, surgical site infection, and overall postoperative complications. This data highlights several specific complications that are influenced by operative time in older patients, and further supports the need for future protocols that seek to safely minimize operative time for posterior lumbar fusion.

Keywords

operative duration lumbar fusion elderly

Introduction

Patients age 65 and older represent the fastest growing cohort in the United States, which is estimated to double by 2050.¹ In addition, the prevalence of chronic low back pain in patients age 65 and older has been increasing over time, which has been mirrored by increasing number of spinal fusions.^2

-5 However, the growing population of older patients undergoing spinal procedures is also exhibiting an increasing rate of comorbidities, contributing to a disproportionately higher risk of complications.^6

-12

Studies have shown that increasing operative time remains a risk factor for postoperative complications among other specialties, including plastic surgery,¹³ breast reconstruction,¹⁴ gynecology,¹⁵ and general surgery.^16,17 For spinal cases, previous studies have focused on all patients undergoing specific procedures, such as fusion for adult spinal deformity,¹⁸ lumbar fusion,¹⁹ and instrumented spinal fusion.²⁰ Age has also been found to be an independent risk factor for postoperative complications among lumbar spine patients,^20

-23 as well as among other specialties.^10,24
-26 However, there is a need for investigation for the implications of operative time among the growing population of elderly lumbar spine patients.

The current study aims to determine the critical operative duration at which more complications occur, as well as which complications increase as operative time increases in patients over the age of 65 undergoing posterior lumbar fusion. By identifying specific ages, time points, and complications, physicians can not only be more aware of the risks of operative time but also prepared for complications that are most likely to occur.

Methods

Data Source

Data was obtained from the American College of Surgeons National Quality Improvement Program (ACS NSQIP) dataset, years 2012 to 2015. The NSQIP collects data from member hospitals for surgical procedures, including patient characteristics (eg, age, sex, weight, height, American Society of Anesthesiologists [ASA] Classification), procedure characteristics (eg, operative duration, procedure codes), and 30-day complications. As the NSQIP is both publicly available and deidentified, this study was not considered human subjects research and was therefore deemed exempt from institutional review board consideration.

Patient Selection

Patients were preliminarily included in the study based on presence of a primary listed Current Procedural Terminology (CPT) code for posterior/posterolateral lumbar fusion (22612). Patients were subsequently excluded if they exhibited any of the following characteristics: age <65, nonelective surgery, revision surgery, emergent surgery, and outpatient surgery, as well as preoperative ventilator dependency, ascites, congestive heart failure within 30 days preoperatively, renal failure, dialysis, disseminated cancer, preoperative open/infected wound, pathologic weight loss, sepsis, and totally dependent functional health status. Patients were also excluded if they underwent spinal fusion at nonlumbar levels or with technique other than posterior/posterolateral, as evidenced by presence of CPT codes 22554, 22585, 22558, 22556, 22551, 22552, 22533, 22532, 22534, 22634, 22633, 22632, 22630, 22600, or 22610. Characteristics of excluded patients are detailed in Supplemental Table S1 (available in the online version of the article); select patients were excluded on multiple criteria.

Outcome Measures

The primary outcome measures in this study were complications occurring up to 30 days postoperatively, including death, any complication, wound dehiscence, pneumonia, urinary tract infection (UTI), stroke/cerebrovascular accident (CVA), transfusion within 72 hours postoperatively, surgical site infection (SSI), sepsis, acute kidney injury (AKI), thromboembolism, major adverse cardiac event (includes cardiac arrest and myocardial infarction), and postoperative intubation.

Independent Variables

The primary independent variable was operative duration, expressed in hours. Variables considered as potential confounders included age group, sex, body mass index (BMI) category, and number of levels fused. Levels fused was calculated as the total number of CPT codes corresponding to single or additional levels of posterior/posterolateral lumbar fusion (22612 and 22614).

Statistical Analysis

Descriptive statistics for both independent variables and postoperative complications were generated. Both bivariate and multivariate analyses utilized logistic regression and analyzed operative duration as a continuous variable. Model discrimination and fit were assessed with the c-statistic and Hosmer and Lemeshow goodness-of-fit (HF GOF) test, respectively. The analyses of postoperative transfusion indicated initial poor GOF. The model was subsequently refined by the removal of ASA classification, yielding a model with HF GOF test P > .05 (ie, achieving a good fit). Analyses of stroke/CVA indicated initial overfitting, resolved via sequential removal of variables with the lowest Wald χ² values (ASA classification, BMI category, and levels fused). All statistical analyses were conducted using SAS 9.4 (SAS Institute, Cary, NC). Statistical significance was considered P < .05.

Results

Descriptive Statistics

In total, 4947 patients were analyzed. The mean operative duration was 3.3 hours (standard deviation [SD] 1.7). The majority of patients were aged 65 to 69 years (34.4%, n = 1700), followed by age 70 to 74 years (30.7%, n = 1519). Most patients were female (57.3%, n = 2836) and with ASA classification of 3 (59.9%, n = 2960). Most patients were of BMI category 25.0 to 29.9 kg/m² (35.2%, n = 2074), followed by 30.0 to 34.9 kg/m² (28.7%, n = 1693). The majority of procedures involved a single level (48.0%, n = 2373) or 2 levels (40.6%, n = 2009; Table 1). Complications occurred in 13.4% (n = 665) of patients overall. The most common complication was blood transfusion (6.3% of patients, n = 313; Table 2).

Table 1.

Patient Characteristics.

Variable	N	%
All patients	4949
Operative duration
Mean	3.3
SD	1.7
Age group
65-69	1700	34.4
70-74	1519	30.7
75-79	1062	21.5
≥80	666	13.5
Sex
Female	2838	57.3
Male	2111	42.7
ASA classification
1 to 2	1833	37.1
3	2960	59.9
4	148	3.0
Missing = 6
BMI group
≤24.9	1025	17.4
25.0-29.9	2074	35.2
30.0-34.9	1693	28.7
35.0-39.0	754	12.8
≥40	354	6.0
Missing = 10
Levels fused
1	2373	48.0
2	2009	40.6
3+	565	11.4

Abbreviations: ASA, American Society of Anesthesiologists; BMI, body mass index.

Table 2.

Complication Frequency.

Complication	N	%
Death	17	0.3
Any complication	665	13.4
Wound dehiscence	17	0.3
Pneumonia	50	1.0
UTI	129	2.6
Stroke/CVA	13	0.3
Transfusion (72 hours)	313	6.3
SSI	313	2.4
Sepsis	60	1.2
AKI	24	0.5
Thromboembolism	74	1.5
MACE	40	0.8
Postoperative intubation	24	0.5

Abbreviations: UTI, urinary tract infection; CVA, cerebrovascular accident; SSI, surgical site infection; AKI, acute kidney injury; MACE, major adverse cardiac event.

Bivariate Analyses

On bivariate analyses, operative duration was associated with significantly higher rates of any complication (P < .0001), UTI (P < .0001), transfusion (P < .0001), AKI (P = .0428), thromboembolism (P < .0001), and postoperative intubation (P = .0323; Table 3).

Table 3.

Bivariate Analyses.

		95% CI
Complication	OR	Upper	Lower	P
Death	1.15	0.091	1.45	.2377
Any complication	1.22	1.17	1.27	<.0001
Dehiscence	1.12	0.88	1.42	.3768
Pneumonia	1.05	0.90	1.23	.5050
UTI	1.20	1.11	1.31	<.0001
Stroke/CVA	1.23	0.97	1.57	.0909
Transfusion	1.24	1.18	1.31	<.0001
SSI	1.12	1.02	1.23	.0212
Sepsis	1.11	0.98	1.27	.1068
AKI	1.21	1.01	1.45	.0428
Thromboembolism	1.25	1.13	1.38	<.0001
MACE	1.06	0.89	1.25	.5267
Intubation	1.22	1.02	1.45	.0323

Abbreviations: OR, odds ratio; CI, confidence interval; UTI, urinary tract infection; CVA, cerebrovascular accident; SSI, surgical site infection; AKI, acute kidney injury; MACE, major adverse cardiac event.

Multivariate Analyses

After adjusting for confounding factors, each incremental hour of operative duration was associated with higher odds of any complication (odds ratio [OR] = 1.22, 95% confidence interval [CI][ = 1.16-1.27, P < .0001; Figure 1), UTI (OR = 1.21, 95% CI = 1.10-1.32, P < .0001), transfusion (OR = 1.25, 95% CI = 1.18-1.32, P < .0001), and thromboembolism (OR = 1.23, 95% CI = 1.10-1.37, P < .0001; Table 4 and Figure 2).

Figure 1.

Predicted probability of any postoperative complications as a function of operative duration.

Table 4.

Multivariate Analyses.

		95% CI
Complication	OR	Upper	Lower	P
Death	1.05	0.81	1.37	.7129
Any complication	1.22	1.16	1.27	<.0001
Would dehiscence	1.07	0.83	1.39	.5971
Pneumonia	1.04	0.88	1.22	.6619
UTI	1.21	1.10	1.32	<.0001
Stroke/CVA	1.22	0.96	1.55	.1114
Transfusion (72 hours)	1.25	1.18	1.32	<.0001
SSI	1.09	0.99	1.21	.0771
Sepsis	1.08	0.94	1.24	.2829
AKI	1.11	0.90	1.36	.3328
Thromboembolism	1.23	1.10	1.37	.0003
MACE	1.04	0.86	1.24	.7003
Postoperative intubation	1.17	0.96	1.43	.1165

Figure 2.

Adjusted association of operative duration and complications.

Discussion

This is the first large database analysis of the incremental effects of operative time on postoperative complications in elderly patient undergoing posterior lumbar fusion. In patients age 65 and older, each incremental hour in operative duration was independently associated with increased odds of postoperative thromboembolism, transfusion, UTI, and total complications. Patients with baseline preoperative risk of complications, such as patients with renal failure, preoperative infection, malignancy, or emergent surgeries, were excluded from analysis; this study therefore highlights the independent effects of operative time on postoperative complication in older, stable patients.

Overall, the rates of postoperative complications in this patient cohort were low, with the most common being transfusion (6.3%), UTI (2.6%), and SSI (2.4%). The postoperative complications identified in this patient cohort are similar to those among previous identified in elderly spine patients,^27,28 and all patients undergoing spinal fusion.^20,29 Numerous studies have also demonstrated the association between operative duration and postoperative complications in orthopedic procedures.^20,22,30,31 However, previous analyses have categorized operative time by durational groups or have identified a threshold duration at which risk of complications are significantly higher. An analysis by Kim et al closely examined the effects of operative duration on postoperative complications in single-level lumbar fusion/instrumentation procedures.¹⁹ Rates of overall, surgical, and medical complications were determined based on categorical operative durations of <2, 2 to 2.99, 3 to 3.99, 4 to 4.99, ≥5 hours. Most postoperative complications exhibited a nonlinear increase in risk across the increasing groups. Risk of organ/space SSI, sepsis, wound dehiscence, and deep vein thrombosis was significantly higher for operations ≥5 hours compared to <2 hours. Risk of overall complications, medical complications, and postoperative transfusions significantly increased in all operative duration groups compared to <2 hours.

Similar to the findings by Kim et al, the current analysis demonstrates a nonlinear increase in risk of complications with each incremental hour in operative time. However, treating operative time as a continuous variable, the current model demonstrates the overall significance of multiplicative increases in risk with increasing duration, as opposed to a threshold effect. For example, the risk of thromboembolism increased significantly with each hour, as indicated by the odds ratio of 1.23 (P < .0001). Compared with the findings by Kim et al, this highlights that the risk of thromboembolism may, in fact, increase across the spectrum of operative duration rather than exhibiting a threshold effect above 5 hours.

There are several limitations inherent to the use of the NSQIP database. First, elements of preoperative characteristics, including prior surgical history, and details of postoperative care are limited. The accuracy of the information that is, indeed, included in NSQIP is restricted by the CPT codes and input from individual institutions. NSQIP also includes complications occurring up to 30 days postoperatively and does not include an important outcome measure in postoperative care of elderly patient, that is, functional status. Of particular importance for our study, NSQIP is used for a variety of surgical procedures and therefore does not capture characteristics specific to spine surgery, such as technique, additional procedures related to implants such as cementation, surgeon experience, open versus minimally invasive procedures, or spine-specific complications such as durotomy, that may affect operative time.

This is the first study to investigate the incremental effects of operative time in elderly lumbar spine patients and holds important clinical implications. While previous studies of operative time have noted various cutoffs in duration that may increase risk of complications, the current study highlights that risk is continuous and multiplicative across the spectrum of operative durations. As the rate of spinal surgeries performed on a growing elderly population continues to expand, the impact of increasing operative time highlights a need for efficient and effective surgical techniques. Interestingly, studies have shown that minimally invasive technique does not confer significantly lower complication rates aside from significantly less blood loss.^32
-34 Therefore, other strategies of optimizing operative time in this cohort of patients is necessary to reduce the risk of other significant complications highlighted in this study. If prolonged operative time in older patients is unavoidable, our results provide a basis for the most pervasive complications that may be avoidable with perioperative interventions.

Conclusion

The current study provides evidence of the strong association between increasing operative time and specific complications in patients age 65 and older undergoing posterior lumbar fusion. This study has built on previous evidence highlighting the most pervasive complications in spinal procedures in the general population and elderly population alike, including blood transfusions, UTIs, SSIs, thromboembolism, and kidney injury. Our results further show that the odds of these complications increase significant with 1-hour increments in operative duration in this patient cohort. Further investigation is necessary to identify specific causality and effective techniques in safely reducing operative time.

Supplemental Material

Supplemental Material, GSJ789117_suppl_mat - Longer Operative Time in Elderly Patients Undergoing Posterior Lumbar Fusion Is Independently Associated With Increased Complication Rate

Supplemental Material, GSJ789117_suppl_mat for Longer Operative Time in Elderly Patients Undergoing Posterior Lumbar Fusion Is Independently Associated With Increased Complication Rate by Alicia E. Hersey, Wesley M. Durand, Adam E. M. Eltorai, J. Mason DePasse, and Alan H. Daniels in Global Spine Journal

Footnotes

Declaration of Conflicting Interests

The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Alan H. Daniels received book royalties from LWW and Springer Grants, personal fees from Orthofix, personal fees from Stryker, personal fees from Spineart, and royalties from Springer. All other authors have no conflicts of interest.

Funding

The author(s) received no financial support for the research, authorship, and/or publication of this article.

Supplemental Material

The supplemental material is available in the online version of the article.

References

Ortman

Velkoff

Hogan

. An aging nation: the older population in the United States. Econ Stat Adm U S Dep Commer. 2014;1964:1–28.

Deyo

Mirza

Martin

Kreuter

Goodman

Jarvik

. Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA. 2010;303:1259–1265.

Freburger

Holmes

Agans

. The rising prevalence of chronic low back pain. Arch Intern Med. 2009;169:251–258.

O’Lynnger

Zuckerman

Morone

Dewan

Vasquez-Castellanos

Cheng

. Trends for spine surgery for the elderly: implications for access to healthcare in North America. Neurosurgery. 2015;77(suppl 4):S136–S141.

Yoshihara

Yoneoka

. National trends in the surgical treatment for lumbar degenerative disc disease: United States, 2000 to 2009. Spine J. 2015;15:265–271.

Basques

Anandasivam

Webb

. Risk factors for blood transfusion with primary posterior lumbar fusion. Spine (Phila Pa 1976). 2015;40:1792–1797.

Bohl

Webb

Lukasiewicz

. Timing of complications after spinal fusion surgery. Spine (Phila Pa 1976). 2015;40:1527–1535.

Finlayson

EVA

Birkmeyer

. Operative mortality with elective surgery in older adults. Eff Clin Pract. 2001;4:172–177.

Goz

Weinreb

McCarthy

Schwab

Lafage

Errico

. Perioperative complications and mortality after spinal fusions: analysis of trends and risk factors. Spine (Phila Pa 1976). 2013;38:1970–1976.

10.

Polanczyk

Marcantonio

Goldman

. Impact of age on perioperative complications and length of stay in patients undergoing noncardiac surgery. Ann Intern Med. 2001;134:637–643.

11.

Sheetz

Guy

Allison

. Improving the care of elderly adults undergoing surgery in Michigan. J Am Geriatr Soc. 2014;62:352–357.

12.

Turrentine

Wang

Simpson

Jones

. Surgical risk factors, morbidity, and mortality in elderly patients. J Am Coll Surg. 2006;203:865–877.

13.

Hardy

Davis

Constantine

. The impact of operative time on complications after plastic surgery: a multivariate regression analysis of 1753 cases. Aesthet Surg J. 2014;34:614–622.

14.

Fischer

Nelson

Tuggle

3rd Serletti

. Complications and morbidity following breast reconstruction—a review of 16 063 cases from the 2005-2010 NSQIP datasets. J Plast Surg Hand Surg. 2014;48:104–114.

15.

Catanzarite

Saha

Pilecki

Kim

Milad

. Longer operative time during benign laparoscopic and robotic hysterectomy is associated with increased 30-day perioperative complications. J Minim Invasive Gynecol. 2015;22:1049–1058.

16.

Jeon

Kim

Jung

. Prolonged operative time in laparoscopic appendectomy: predictive factors and outcomes. Int J Surg. 2016;36(pt A):225–232.

17.

Pessaux

Msika

Atalla

Hay

Flamant

. Risk factors for postoperative infectious complications in noncolorectal abdominal surgery: a multivariate analysis based on a prospective multicenter study of 4718 patients. Arch Surg. 2003;138:314–324.

18.

Samuel

Anandasivam

. After posterior fusions for adult spinal deformity, operative time is more predictive of perioperative morbidity, rather than surgical invasiveness: a need for speed? Spine (Phila Pa 1976). 2017;42:1880–1887.

19.

Kim

Hsu

De Oliveira

Jr Saha

Kim

. Operative duration as an independent risk factor for postoperative complications in single-level lumbar fusion: an analysis of 4588 surgical cases. Spine (Phila Pa 1976). 2014;39:510–520.

20.

Akins

Harris

Alvarez

. Risk factors associated with 30-day readmissions after instrumented spine surgery in 14 939 patients: 30-day readmissions after instrumented spine surgery. Spine (Phila Pa 1976). 2015;40:1022–1032.

21.

Passias

Gaber-Baylis

Girardi

Memtsoudis

. Comparative in-hospital morbidity and mortality after revision versus primary thoracic and lumbar spine fusion. Spine J. 2010;10:881–889.

22.

Pugely

Martin

Gao

Mendoza-Lattes

. Outpatient surgery reduces short-term complications in lumbar discectomy: an analysis of 4310 patients from the ACS-NSQIP database. Spine (Phila Pa 1976). 2013;38:264–271.

23.

Puvanesarajah

Nourbakhsh

Hassanzadeh

Shimer

Shen

Singla

. Readmission rates, reasons, and risk factors in elderly patients treated with lumbar fusion for degenerative pathology. Spine (Phila Pa 1976). 2016;41:1933–1938.

24.

Erekson

Yip

Ciarleglio

Fried

. Postoperative complications after gynecologic surgery. Obstet Gynecol. 2011;118:785–793.

25.

Lidsky

Thacker

Lagoo-Deenadayalan

Scarborough

. Advanced age is an independent predictor for increased morbidity and mortality after emergent surgery for diverticulitis. Surgery. 2012;152:465–472.

26.

Manilich

Vogel

Kiran

Church

Seyidova-Khoshknabi

Remzi

. Key factors associated with postoperative complications in patients undergoing colorectal surgery. Dis Colon Rectum. 2013;56:64–71.

27.

Balabaud

Pitel

Caux

. Lumbar spine surgery in patients 80 years of age or older: morbidity and mortality. Eur J Orthop Surg Traumatol. 2015;25(suppl 1):S205–S212.

28.

Carreon

Puno

Dimar

2nd Glassman

Johnson

. Perioperative complications of posterior lumbar decompression and arthrodesis in older adults. J Bone Joint Surg Am. 2003;85-A:2089–2092.

29.

Lee

Kothari

Phan

. Incidence and risk factors for 30-day unplanned readmissions after elective posterior lumbar fusion. Spine (Phila Pa 1976). 2018;43:41–48.

30.

Peersman

Laskin

Davis

Peterson

Richart

. Prolonged operative time correlates with increased infection rate after total knee arthroplasty. HSS J. 2006;2:70–72.

31.

Saleh

Thirukumaran

Mesfin

Molinari

. Complications and readmission after lumbar spine surgery in elderly patients: an analysis of 2320 patients. Spine J. 2017;17:1106–1112.

32.

Goldstein

Macwan

Sundararajan

Rampersaud

. Comparative outcomes of minimally invasive surgery for posterior lumbar fusion: a systematic review. Clin Orthop Relat Res. 2014;472:1727–1737.

33.

Goldstein

Phillips

Rampersaud

. Comparative effectiveness and economic evaluations of open versus minimally invasive posterior or transforaminal lumbar interbody fusion: a systematic review. Spine (Phila Pa 1976). 2016;41(suppl 8):S74–S89.

34.

Sidhu

Henkelman

Vaccaro

. Minimally invasive versus open posterior lumbar interbody fusion: a systematic review. Clin Orthop Relat Res. 2014;472:1792–1799.

Supplementary Material

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