Emotion-related impulsivity (ERI) shows robust longitudinal associations with psychiatric disorders, aggression, and suicidality, yet a parsimonious account of its neurocognitive correlates has not been offered. We connect ERI with the glutamate-amplifies-noradrenergic-effects (GANE) model, a framework describing how norepinephrine tunes “hotspots” of brain activation during heightened physiological arousal. First, we systematically reviewed studies of ERI and task-based functional MRI. Meta-analysis of significant effects yielded one cluster in right inferior frontal gyrus. Twenty-six of 30 significant effects systematically colocalized in neuroanatomical hotspots in each corresponding task, in line with GANE. Second, adults recruited for a range of psychopathology (N = 120) completed a reward/punishment go/no-go task while undergoing functional MRI. ERI correlated with stronger nucleus-accumbens activation for a model sensitive to heightened trial reward and in anterior cingulate for models sensitive to heightened trial arousal. Findings provide empirical support for the relevance of GANE hotspot mechanisms to ERI.
Albein-UriosN.Verdejo-RománJ.AsensioS.Soriano-MasC.Martínez-GonzálezJ. M.Verdejo-GarcíaA. (2014). Re-appraisal of negative emotions in cocaine dependence: Dysfunctional corticolimbic activation and connectivity. Addiction Biology, 19(3), 415–426.
2.
Albein-UriosN.Verdejo-RománJ.Soriano-MasC.AsensioS.Martínez-GonzálezJ. M.Verdejo-GarcíaA. (2013). Cocaine users with comorbid Cluster B personality disorders show dysfunctional brain activation and connectivity in the emotional regulation networks during negative emotion maintenance and reappraisal. European Neuropsychopharmacology, 23(12), 1698–1707. https://doi.org/10.1016/j.euroneuro.2013.04.012
3.
AllenK. J. D.HooleyJ. M. (2019). Negative Emotional Action Termination (NEAT): Support for a cognitive mechanism underlying negative urgency in nonsuicidal self-injury. Behavior Therapy, 50(5), 924–937. https://doi.org/10.1016/j.beth.2019.02.001
4.
AllenK. J. D.JohnsonS. L.BurkeT. A.SammonM. M.WuC.KramerM. A.WuJ.SchattenH. T.ArmeyM. F.HooleyJ. M. (2021). Validation of an emotional stop-signal task to probe individual differences in emotional response inhibition: Relationships with positive and negative urgency. Brain and Neuroscience Advances, 5. https://doi.org/10.1177/23982128211058269
5.
American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.).
6.
AshburnerJ.BarnesG.Chun-ChuanC.DaunizeauJ.FlandinG.FristonK.GitelmanD.GlaucheV.HensonR.HuttonC.JafarianA.KiebelS.KilnerJ.LitvakV.MattoutJ.MoranR.PennyW.PhillipsC.RaziA.. . . ZeidmanP. (2014). SPM12 Manual. Wellcome Trust Centre for Neuroimaging. https://www.fil.ion.ucl.ac.uk/spm/doc/spm12_manual.pdf
7.
AuerbachR. P.StewartJ. G.JohnsonS. L. (2017). Impulsivity and suicidality in adolescent inpatients. Journal of Abnormal Child Psychology, 45(1), 91–103. https://doi.org/10.1007/s10802-016-0146-8
8.
Barkley-LevensonE.XueF.DroutmanV.MillerL. C.SmithB. J.JeongD.LuZ.-L.BecharaA.ReadS. J. (2018). Prefrontal cortical activity during the Stroop task: New insights into the why and the who of real-world risky sexual behavior. Annals of Behavioral Medicine, 52(5), Article 5. https://doi.org/10.1093/abm/kax019
9.
BatesD.MächlerM.BolkerB.WalkerS. (2015). Fitting linear mixed-effects models using lme4. Journal of Statistical Software, 67(1), 1–48. https://doi.org/10.18637/jss.v067.i01
10.
BergJ. M.LatzmanR. D.BliwiseN. G.LilienfeldS. O. (2015). Parsing the heterogeneity of impulsivity: A meta-analytic review of the behavioral implications of the UPPS for psychopathology. Psychological Assessment, 27(4), 1129–1146. https://doi.org/10.1037/pas0000111
11.
BillieuxJ.HeerenA.RochatL.MaurageP.BayardS.BetR.Besche-RichardC.Challet-BoujuG.CarréA.DevosG.FlayelleM.GierskiF.Grall-BronnecM.KernL.KhazaalY.LançonC.LannoyS.MichaelG. A.RaffardS.. . . BaggioS. (2021). Positive and negative urgency as a single coherent construct: Evidence from a large-scale network analysis in clinical and non-clinical samples. Journal of Personality, 89(6), 1252–1262. https://doi.org/10.1111/jopy.12655
12.
BresinK.CarterD. L.GordonK. H. (2013). The relationship between trait impulsivity, negative affective states, and urge for nonsuicidal self-injury: A daily diary study. Psychiatry Research, 205(3), 227–231. https://doi.org/10.1016/j.psychres.2012.09.033
13.
BrettM.AntonJ.-L.ValabregueR.PolineJ.-B. (2002). Region of interest analysis using the MarsBar toolbox for SPM 99. Neuroimage, 16(2), S497.
14.
BurnetteE. M.GrodinE. N.LimA. C.MacKillopJ.KarnoM. P.RayL. A. (2019). Association between impulsivity and neural activation to alcohol cues in heavy drinkers. Psychiatry Research: Neuroimaging, 293, 110986.
15.
CanaleN.VienoA.GriffithsM. D.RubaltelliE.SantinelloM. (2015). Trait urgency and gambling problems in young people by age: The mediating role of decision-making processes. Addictive Behaviors, 46, 39–44. https://doi.org/10.1016/j.addbeh.2015.02.020
16.
Carrier EmondF.GagnonJ.NoletK.CyrG.RouleauJ.-L. (2018). What money can’t buy: Different patterns in decision making about sex and money predict past sexual coercion perpetration. Archives of Sexual Behavior, 47(2), Article 2. https://doi.org/10.1007/s10508-017-1116-0
17.
CarverC. S.JohnsonS. L. (2018). Impulsive reactivity to emotion and vulnerability to psychopathology. American Psychologist, 73(9), 1067–1078. https://doi.org/10.1037/amp0000387
18.
CarverC. S.JohnsonS. L.JoormannJ.KimY.NamJ. Y. (2011). Serotonin transporter polymorphism interacts with childhood adversity to predict aspects of impulsivity. Psychological Science, 22(5), 589–595. https://doi.org/10.1177/0956797611404085
19.
CarverC. S.JohnsonS. L.TimpanoK. R. (2017). Toward a functional view of the p factor in psychopathology. Clinical Psychological Science, 5(5), 880–889. https://doi.org/10.1177/2167702617710037
20.
ChandlerD. J.GaoW.-J.WaterhouseB. D. (2014). Heterogeneous organization of the locus coeruleus projections to prefrontal and motor cortices. Proceedings of the National Academy of Sciences, 111(18), 6816–6821. https://doi.org/10.1073/pnas.1320827111
21.
ChaseH. W.FournierJ. C.BertocciM. A.GreenbergT.AslamH.StifflerR.LockovichJ.GraurS.BebkoG.ForbesE. E.PhillipsM. L. (2017). A pathway linking reward circuitry, impulsive sensation-seeking and risky decision-making in young adults: Identifying neural markers for new interventions. Translational Psychiatry, 7(4), Article e1096. https://doi.org/10.1038/tp.2017.60
22.
ChavanC. F.MouthonM.DraganskiB.van der ZwaagW.SpiererL. (2015). Differential patterns of functional and structural plasticity within and between inferior frontal gyri support training-induced improvements in inhibitory control proficiency. Human Brain Mapping, 36(7), 2527–2543. https://doi.org/10.1002/hbm.22789
23.
ChesterD. S.LynamD. R.MilichR.PowellD. K.AndersenA. H.DeWallC. N. (2016). How do negative emotions impair self-control? A neural model of negative urgency. NeuroImage, 132, 43–50. https://doi.org/10.1016/j.neuroimage.2016.02.024
24.
ChiuY.-C.CoolsR.AronA. R. (2014). Opposing effects of appetitive and aversive cues on go/no-go behavior and motor excitability. Journal of Cognitive Neuroscience, 26(8), 1851–1860. https://doi.org/10.1162/jocn_a_00585
25.
CinarO.ViechtbauerW. (2022). The poolr package for combining independent and dependent p values. Journal of Statistical Software, 101(1), 1–42. https://doi.org/10.18637/jss.v101.i01
26.
ClewettD. V.HuangR.VelascoR.LeeT.-H.MatherM. (2018). Locus coeruleus activity strengthens prioritized memories under arousal. The Journal of Neuroscience, 38(6), 1558–1574. https://doi.org/10.1523/JNEUROSCI.2097-17.2017
27.
ClewettD. V.LeeT.-H.GreeningS.PonzioA.MargalitE.MatherM. (2016). Neuromelanin marks the spot: Identifying a locus coeruleus biomarker of cognitive reserve in healthy aging. Neurobiology of Aging, 37, 117–126. https://doi.org/10.1016/j.neurobiolaging.2015.09.019
28.
ColeM. W.SchneiderW. (2007). The cognitive control network: Integrated cortical regions with dissociable functions. NeuroImage, 37(1), 343–360. https://doi.org/10.1016/j.neuroimage.2007.03.071
29.
ConnollyJ. D.GoodaleM. A.GoltzH. C.MunozD. P. (2005). fMRI activation in the human frontal eye field is correlated with saccadic reaction time. Journal of Neurophysiology, 94(1), 605–611. https://doi.org/10.1152/jn.00830.2004
30.
CriaudM.BoulinguezP. (2013). Have we been asking the right questions when assessing response inhibition in go/no-go tasks with fMRI? A meta-analysis and critical review. Neuroscience & Biobehavioral Reviews, 37(1), 11–23. https://doi.org/10.1016/j.neubiorev.2012.11.003
31.
CydersM. A.CoskunpinarA. (2011). Measurement of constructs using self-report and behavioral lab tasks: Is there overlap in nomothetic span and construct representation for impulsivity?Clinical Psychology Review, 31(6), Article 6. https://doi.org/10.1016/j.cpr.2011.06.001
32.
CydersM. A.DzemidzicM.EilerW. J.CoskunpinarA.KaryadiK.KarekenD. A. (2014). Negative urgency and ventromedial prefrontal cortex responses to alcohol cues: fMRI evidence of emotion-based impulsivity. Alcoholism: Clinical and Experimental Research, 38(2), 409–417.
33.
CydersM. A.DzemidzicM.EilerW. J.CoskunpinarA.KaryadiK. A.KarekenD. A. (2015). Negative urgency mediates the relationship between amygdala and orbitofrontal cortex activation to negative emotional stimuli and general risk-taking. Cerebral Cortex, 25(11), 4094–4102. https://doi.org/10.1093/cercor/bhu123
34.
CydersM. A.SmithG. T. (2007). Mood-based rash action and its components: Positive and negative urgency. Personality and Individual Differences, 43(4), 839–850. https://doi.org/10.1016/j.paid.2007.02.008
35.
CydersM. A.SmithG. T.SpillaneN. S.FischerS.AnnusA. M.PetersonC. (2007). Integration of impulsivity and positive mood to predict risky behavior: Development and validation of a measure of positive urgency. Psychological Assessment, 19(1), 107–118. https://doi.org/10.1037/1040-3590.19.1.107
36.
DahlgrenM. K.HooleyJ. M.BestS. G.SagarK. A.GonencA.GruberS. A. (2018). Prefrontal cortex activation during cognitive interference in nonsuicidal self-injury. Psychiatry Research: Neuroimaging, 277, 28–38. https://doi.org/10.1016/j.pscychresns.2018.04.006
37.
DekkerM. R.JohnsonS. L. (2018). Major depressive disorder and emotion-related impulsivity: Are both related to cognitive inhibition?Cognitive Therapy and Research, 42(4), Article 4. https://doi.org/10.1007/s10608-017-9885-2
38.
DirA. L.AllebachC. L.HummerT. A.AdamsZ. W.AalsmaM. C.FinnP. R.NurnbergerJ. I.HulvershornL. A. (2020). Atypical cortical activation during risky decision making in disruptive behavior disordered youths with histories of suicidal ideation. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(5), 510–519. https://doi.org/10.1016/j.bpsc.2019.10.016
39.
DirA. L.KaryadiK.CydersM. A. (2013). The uniqueness of negative urgency as a common risk factor for self-harm behaviors, alcohol consumption, and eating problems. Addictive Behaviors, 38(5), 2158–2162. https://doi.org/10.1016/j.addbeh.2013.01.025
40.
EdmistonE. K.FournierJ. C.ChaseH. W.BertocciM. A.GreenbergT.AslamH. A.LockovichJ.GraurS.BebkoG.ForbesE. E.StifflerR.PhillipsM. L. (2020). Assessing relationships among impulsive sensation seeking, reward circuitry activity, and risk for psychopathology: A functional magnetic resonance imaging replication and extension study. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 5(7), 660–668.
41.
EickhoffS. B.LairdA. R.GrefkesC.WangL. E.ZillesK.FoxP. T. (2009). Coordinate-based activation likelihood estimation meta-analysis of neuroimaging data: A random-effects approach based on empirical estimates of spatial uncertainty. Human Brain Mapping, 30(9), 2907–2926. https://doi.org/10.1002/hbm.20718
42.
EickhoffS. B.NicholsT. E.LairdA. R.HoffstaedterF.AmuntsK.FoxP. T.BzdokD.EickhoffC. R. (2016). Behavior, sensitivity, and power of activation likelihood estimation characterized by massive empirical simulation. NeuroImage, 137, 70–85. https://doi.org/10.1016/j.neuroimage.2016.04.072
43.
EilerW. J.IIDzemidzicM.CaseK. R.ArmstrongC. L.MattesR. D.CydersM. A.ConsidineR. V.KarekenD. A. (2014). Ventral frontal satiation-mediated responses to food aromas in obese and normal-weight women. The American Journal of Clinical Nutrition, 99(6), 1309–1318.
44.
ElliottM. L.KnodtA. R.IrelandD.MorrisM. L.PoultonR.RamrakhaS.SisonM. L.MoffittT. E.CaspiA.HaririA. R. (2020). What is the test-retest reliability of common task-functional MRI measures? New empirical evidence and a meta-analysis. Psychological Science, 31(7), 792–806. https://doi.org/10.1177/0956797620916786
45.
ElliottM. V.EsmailS. A. S.WeinerK. S.JohnsonS. L. (2023). Neuroanatomical correlates of emotion-related impulsivity. Biological Psychiatry, 93(6), 566–574. https://doi.org/10.1016/j.biopsych.2022.07.018
46.
ElliottM. V.JohnsonS. L.PearlsteinJ. G.Muñoz LopezD. E.KerenH. (2023). Emotion-related impulsivity and risky decision-making: A systematic review and meta-regression. Clinical Psychology Review, 100, Article 102232. https://doi.org/10.1016/j.cpr.2022.102232
47.
FinkK.GothertM.MolderingsG.SchlickerE. (1989). N-Methyl-d-aspartate (NMDA) receptor-mediated stimulation of noradrenaline release, but not release of other neurotransmitters, in the rat brain cortex: Receptor location, characterization and desensitization. Naunyn-Schmiedeberg’s Archives of Pharmacology, 339(5), 514–521. https://doi.org/10.1007/BF00167254
48.
FirstM. B. (2015). Structured clinical interview for the DSM (SCID). In CautinR. L.LilienfeldS. O. (Eds.), The encyclopedia of clinical psychology. John Wiley & Sons, Inc. https://doi.org/10.1002/9781118625392.wbecp351
49.
FischerS.SmithG.CydersM. (2008). Another look at impulsivity: A meta-analytic review comparing specific dispositions to rash action in their relationship to bulimic symptoms. Clinical Psychology Review, 28(8), 1413–1425. https://doi.org/10.1016/j.cpr.2008.09.001
GreenbergT.BertocciM. A.ChaseH. W.StifflerR.AslamH. A.GraurS.BebkoG.LockovichJ. C.PhillipsM. L. (2017). Mediation by anxiety of the relationship between amygdala activity during emotion processing and poor quality of life in young adults. Translational Psychiatry, 7, e1178.
52.
GunnR. L.FinnP. R. (2015). Applying a dual process model of self-regulation: The association between executive working memory capacity, negative urgency, and negative mood induction on pre-potent response inhibition. Personality and Individual Differences, 75, 210–215. https://doi.org/10.1016/j.paid.2014.11.033
53.
GustavsonD. E.FriedmanN. P.FontanillasP.ElsonS. L., the 23andMe Research Team, PalmerA. A.Sanchez-RoigeS. (2020). The latent genetic structure of impulsivity and its relation to internalizing psychopathology. Psychological Science, 31(8), 1025–1035. https://doi.org/10.1177/0956797620938160
54.
HalcombM.DzemidzicM.ShenY. I.LinZ.ButcherT. J.YoderK. K.OberlinB. (2022). Delay discounting and alcohol consumption correlate with dorsal anterior insula activation during choice in nontreatment–seeking heavy drinkers. Alcoholism: Clinical and Experimental Research, 46(8), 1397–1407.
55.
HampshireA.ChamberlainS. R.MontiM. M.DuncanJ.OwenA. M. (2010). The role of the right inferior frontal gyrus: Inhibition and attentional control. NeuroImage, 50(3), 1313–1319. https://doi.org/10.1016/j.neuroimage.2009.12.109
56.
HamzaC. A.WilloughbyT.HefferT. (2015). Impulsivity and nonsuicidal self-injury: A review and meta-analysis. Clinical Psychology Review, 38, 13–24. https://doi.org/10.1016/j.cpr.2015.02.010
57.
HenssenA.ZillesK.Palomero-GallagherN.SchleicherA.MohlbergH.GerbogaF.EickhoffS. B.BludauS.AmuntsK. (2016). Cytoarchitecture and probability maps of the human medial orbitofrontal cortex. Cortex, 75, 87–112. https://doi.org/10.1016/j.cortex.2015.11.006
58.
HermanA. M.ElliottM. V.JohnsonS. L. (2023). Emotion-related impulsivity moderates the role of arousal on reflection impulsivity. Pharmacology Biochemistry and Behavior, 225, Article 173557. https://doi.org/10.1016/j.pbb.2023.173557
59.
HoptmanM. J.AntoniusD.MauroC. J.ParkerE. M.JavittD. C. (2014). Cortical thinning, functional connectivity, and mood-related impulsivity in schizophrenia: Relationship to aggressive attitudes and behavior. American Journal of Psychiatry, 171(9), 939–948. https://doi.org/10.1176/appi.ajp.2014.13111553
60.
JacobsH. I.PriovoulosN.PoserB. A.PagenL. H.IvanovD.VerheyF. R.UludağK. (2020). Dynamic behavior of the locus coeruleus during arousal-related memory processing in a multi-modal 7T fMRI paradigm. eLife, 9, Article e52059. https://doi.org/10.7554/eLife.52059
61.
JauharS.ForteaL.SolanesA.Albajes-EizagirreA.McKennaP. J.RaduaJ. (2021). Brain activations associated with anticipation and delivery of monetary reward: A systematic review and meta-analysis of fMRI studies. PLOS ONE, 16(8), Article e0255292. https://doi.org/10.1371/journal.pone.0255292
62.
JohnsonS. L.CarverC. S. (2016). Emotion-relevant impulsivity predicts sustained anger and aggression after remission in bipolar I disorder. Journal of Affective Disorders, 189, 169–175. https://doi.org/10.1016/j.jad.2015.07.050
63.
JohnsonS. L.CarverC. S.JoormannJ. (2013). Impulsive responses to emotion as a transdiagnostic vulnerability to internalizing and externalizing symptoms. Journal of Affective Disorders, 150(3), 872–878. https://doi.org/10.1016/j.jad.2013.05.004
64.
JohnsonS. L.ElliottM. V.CarverC. S. (2020). Impulsive responses to positive and negative emotions: Parallel neurocognitive correlates and their implications. Biological Psychiatry, 87(4), Article 4. https://doi.org/10.1016/j.biopsych.2019.08.018
65.
JohnsonS. L.HaaseC. M.BeermannU.SanchezA. H.TharpJ. A.LwiS. J.CaseyJ. J.NguyenN. K. (2017). Positive urgency and emotional reactivity: Evidence for altered responding to positive stimuli. Emotion, 17(3), 442–449. https://doi.org/10.1037/emo0000240
66.
JohnsonS. L.MehtaH.KetterT. A.GotlibI. H.KnutsonB. (2019). Neural responses to monetary incentives in bipolar disorder. NeuroImage: Clinical, 24, Article 102018. https://doi.org/10.1016/j.nicl.2019.102018
67.
JohnsonS. L.TharpJ. A.PeckhamA. D.CarverC. S.HaaseC. M. (2017). A path model of different forms of impulsivity with externalizing and internalizing psychopathology: Towards greater specificity. British Journal of Clinical Psychology, 56(3), 235–252. https://doi.org/10.1111/bjc.12135
68.
JohnsonS. L.TharpJ. A.PeckhamA. D.SanchezA. H.CarverC. S. (2016). Positive urgency is related to difficulty inhibiting prepotent responses. Emotion, 16(5), Article 5. https://doi.org/10.1037/emo0000182
69.
JosephJ. E.LiuX.JiangY.LynamD.KellyT. H. (2009). Neural correlates of emotional reactivity in sensation seeking. Psychological Science, 20(2), 215–223. https://doi.org/10.1111/j.1467-9280.2009.02283.x
70.
JoshiS.LiY.KalwaniR. M.GoldJ. I. (2016). Relationships between pupil diameter and neuronal activity in the locus coeruleus, colliculi, and cingulate cortex. Neuron, 89(1), 221–234. https://doi.org/10.1016/j.neuron.2015.11.028
71.
KatzmanR.BrownT.FuldP.PeckA.SchechterR.SchiimmelH. (1983). Validation of a short Orientation-Memory-Concentration Test of cognitive impairment. American Journal of Psychiatry, 140(6), 734–739. https://doi.org/10.1176/ajp.140.6.734
72.
KnutsonB.AdamsC. M.FongG. W.HommerD. (2001). Anticipation of increasing monetary reward selectively recruits nucleus accumbens. The Journal of Neuroscience, 21(16), Article RC159. https://doi.org/10.1523/JNEUROSCI.21-16-j0002.2001
73.
Krause-UtzA.CackowskiS.DaffnerS.SobanskiE.PlichtaM. M.BohusM.EndeG.SchmahlC. (2016). Delay discounting and response disinhibition under acute experimental stress in women with borderline personality disorder and adult attention deficit hyperactivity disorder. Psychological Medicine, 46(15), Article 15. https://doi.org/10.1017/S0033291716001677
74.
LeeT.-H.GreeningS. G.MatherM. (2015). Encoding of goal-relevant stimuli is strengthened by emotional arousal in memory. Frontiers in Psychology, 6, Article 1173. https://doi.org/10.3389/fpsyg.2015.01173
75.
LeeT.-H.GreeningS. G.UenoT.ClewettD.PonzioA.SakakiM.MatherM. (2018). Arousal increases neural gain via the locus coeruleus–noradrenaline system in younger adults but not in older adults. Nature Human Behaviour, 2(5), 356–366. https://doi.org/10.1038/s41562-018-0344-1
76.
LeeT.-H.SakakiM.ChengR.VelascoR.MatherM. (2014). Emotional arousal amplifies the effects of biased competition in the brain. Social Cognitive and Affective Neuroscience, 9(12), 2067–2077. https://doi.org/10.1093/scan/nsu015
77.
LeonA. C.OlfsonM.PorteraL.FarberL.SheehanD. V. (1997). Assessing psychiatric impairment in primary care with the Sheehan Disability Scale. The International Journal of Psychiatry in Medicine, 27(2), 93–105. https://doi.org/10.2190/T8EM-C8YH-373N-1UWD
78.
LynamD. R.MillerJ. D.MillerD. J.BornovalovaM. A.LejuezC. W. (2011). Testing the relations between impulsivity-related traits, suicidality, and nonsuicidal self-injury: A test of the incremental validity of the UPPS model. Personality Disorders: Theory, Research, and Treatment, 2(2), 151–160. https://doi.org/10.1037/a0019978
79.
MarkovicJ.AndersonA. K.ToddR. M. (2014). Tuning to the significant: Neural and genetic processes underlying affective enhancement of visual perception and memory. Behavioural Brain Research, 259, 229–241. https://doi.org/10.1016/j.bbr.2013.11.018
80.
MatherM.ClewettD.SakakiM.HarleyC. W. (2016). Norepinephrine ignites local hotspots of neuronal excitation: How arousal amplifies selectivity in perception and memory. Behavioral and Brain Sciences, 39, Article e200. https://doi.org/10.1017/S0140525X15000667
MenonV.D’EspositoM. (2022). The role of PFC networks in cognitive control and executive function. Neuropsychopharmacology, 47(1), 90–103. https://doi.org/10.1038/s41386-021-01152-w
83.
NavasJ. F.Contreras-RodríguezO.Verdejo-RománJ.Perandrés-GómezA.Albein-UriosN.Verdejo-GarcíaA.PeralesJ. C. (2017). Trait and neurobiological underpinnings of negative emotion regulation in gambling disorder. Addiction, 112(6), 1086–1094.
84.
OldhamS.MurawskiC.FornitoA.YoussefG.YücelM.LorenzettiV. (2018). The anticipation and outcome phases of reward and loss processing: A neuroimaging meta-analysis of the monetary incentive delay task. Human Brain Mapping, 39(8), 3398–3418. https://doi.org/10.1002/hbm.24184
85.
OwensM. M.AmlungM. T.StojekM.MacKillopJ. (2018). Negative urgency moderates reactivity to laboratory stress inductions. Journal of Abnormal Psychology, 127(4), Article 4. https://doi.org/10.1037/abn0000350
86.
PearlsteinJ. G.JohnsonS. L.ModaviK.PeckhamA. D.CarverC. S. (2019). Neurocognitive mechanisms of emotion-related impulsivity: The role of arousal. Psychophysiology, 56(2), Article e13293. https://doi.org/10.1111/psyp.13293
87.
PearlsteinJ. G.JohnsonS. L.TimpanoK. R.StamatisC. A.RobisonM.CarverC. S. (2024). Emotion-related impulsivity across transdiagnostic dimensions of psychopathology. Journal of Personality, 92(2), 342–360. https://doi.org/10.1111/jopy.12825
88.
PeckhamA. D.JohnsonS. L. (2018). Cognitive control training for emotion-related impulsivity. Behaviour Research and Therapy, 105, 17–26. https://doi.org/10.1016/j.brat.2018.03.009
PessoaL.AdolphsR. (2010). Emotion processing and the amygdala: From a “low road” to “many roads” of evaluating biological significance. Nature Reviews Neuroscience, 11(11), 773–782. https://doi.org/10.1038/nrn2920
91.
PetraliaR.YokotaniN.WentholdR. (1994). Light and electron microscope distribution of the NMDA receptor subunit NMDAR1 in the rat nervous system using a selective anti-peptide antibody. The Journal of Neuroscience, 14(2), 667–696. https://doi.org/10.1523/JNEUROSCI.14-02-00667.1994
92.
PourtoisG.SchettinoA.VuilleumierP. (2013). Brain mechanisms for emotional influences on perception and attention: What is magic and what is not. Biological Psychology, 92(3), 492–512. https://doi.org/10.1016/j.biopsycho.2012.02.007
93.
R Core Team. (2018). R: A language and environment for statistical computing, version 3.5.1. R Foundation for Statistical Computing.
94.
RamosB. P.ArnstenA. F. T. (2007). Adrenergic pharmacology and cognition: Focus on the prefrontal cortex. Pharmacology & Therapeutics, 113(3), 523–536. https://doi.org/10.1016/j.pharmthera.2006.11.006
95.
Richter-LevinG.AkiravI. (2003). Emotional tagging of memory formation—In the search for neural mechanisms. Brain Research Reviews, 43(3), 247–256. https://doi.org/10.1016/j.brainresrev.2003.08.005
96.
RileyE. N.CombsJ. L.JordanC. E.SmithG. T. (2015). Negative urgency and lack of perseverance: Identification of differential pathways of onset and maintenance risk in the longitudinal prediction of nonsuicidal self-injury. Behavior Therapy, 46(4), 439–448. https://doi.org/10.1016/j.beth.2015.03.002
97.
RileyE. N.RukavinaM.SmithG. T. (2016). The reciprocal predictive relationship between high-risk personality and drinking: An 8-wave longitudinal study in early adolescents. Journal of Abnormal Psychology, 125(6), 798–804. https://doi.org/10.1037/abn0000189
98.
RoxburghA. D.WhiteD. J.CornwellB. R. (2022). Negative urgency is related to impaired response inhibition during threatening conditions. Acta Psychologica, 228, Article 103648. https://doi.org/10.1016/j.actpsy.2022.103648
99.
RuanJ.BludauS.Palomero-GallagherN.CaspersS.MohlbergH.EickhoffS. B.SeitzR. J.AmuntsK. (2018). Cytoarchitecture, probability maps, and functions of the human supplementary and pre-supplementary motor areas. Brain Structure and Function, 223(9), 4169–4186. https://doi.org/10.1007/s00429-018-1738-6
SalgadoH.Garcia-OscosF.MartinolichL.HallS.RestomR.TsengK. Y.AtzoriM. (2012). Pre- and postsynaptic effects of norepinephrine on γ-aminobutyric acid-mediated synaptic transmission in layer 2/3 of the rat auditory cortex. Synapse, 66(1), 20–28. https://doi.org/10.1002/syn.20979
102.
SchaumM.PinzutiE.SebastianA.LiebK.FriesP.MobascherA.JungP.WibralM.TüscherO. (2021). Right inferior frontal gyrus implements motor inhibitory control via beta-band oscillations in humans. eLife, 10, Article e61679. https://doi.org/10.7554/eLife.61679
103.
SeeleyW. W. (2019). The salience network: A neural system for perceiving and responding to homeostatic demands. The Journal of Neuroscience, 39(50), 9878–9882. https://doi.org/10.1523/JNEUROSCI.1138-17.2019
104.
SettlesR. E.FischerS.CydersM. A.CombsJ. L.GunnR. L.SmithG. T. (2012). Negative urgency: A personality predictor of externalizing behavior characterized by neuroticism, low conscientiousness, and disagreeableness. Journal of Abnormal Psychology, 121(1), 160–172. https://doi.org/10.1037/a0024948
105.
SharmaL.MarkonK. E.ClarkL. A. (2014). Toward a theory of distinct types of “impulsive” behaviors: A meta-analysis of self-report and behavioral measures. Psychological Bulletin, 140(2), 374–408. https://doi.org/10.1037/a0034418
106.
SimmondsD. J.PekarJ. J.MostofskyS. H. (2008). Meta-analysis of Go/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent. Neuropsychologia, 46(1), 224–232. https://doi.org/10.1016/j.neuropsychologia.2007.07.015
107.
SmithB. J.XueF.DroutmanV.Barkley-LevensonE.MelroseA. J.MillerL. C.MonterossoJ. R.BecharaA.ApplebyP. R.ChristensenJ. L.GodoyC. G.ReadS. J. (2018). Virtually ‘in the heat of the moment’: Insula activation in safe sex negotiation among risky men. Social Cognitive and Affective Neuroscience, 13(1), 80–91. https://doi.org/10.1093/scan/nsx137
SmithG. T.FischerS.CydersM. A.AnnusA. M.SpillaneN. S.McCarthyD. M. (2007). On the validity and utility of discriminating among impulsivity-like traits. Assessment, 14(2), 155–170. https://doi.org/10.1177/1073191106295527
110.
SmithG. T.GullerL.ZapolskiT. C. B. (2013). A comparison of two models of urgency: Urgency predicts both rash action and depression in youth. Clinical Psychological Science, 1(3), 266–275. https://doi.org/10.1177/2167702612470647
111.
SteeleJ. S.BertocciM.EckstrandK.ChaseH. W.StifflerR.AslamH.LockovichJ.BebkoG.PhillipsM. L. (2021). A specific neural substrate predicting current and future impulsivity in young adults. Molecular Psychiatry, 26(9), 4919–4930. https://doi.org/10.1038/s41380-021-01017-0
112.
StinsonE. A.SullivanR. M.NavarroG. Y.WallaceA. L.LarsonC. L.LisdahlK. M. (2024). Childhood adversity is associated with reduced BOLD response in inhibitory control regions amongst preadolescents from the ABCD study. Developmental Cognitive Neuroscience, 67, Article 101378. https://doi.org/10.1016/j.dcn.2024.101378
113.
SutherlandM. R.MatherM. (2012). Negative arousal amplifies the effects of saliency in short-term memory. Emotion, 12(6), 1367–1372. https://doi.org/10.1037/a0027860
Tervo-ClemmensB.QuachA.LunaB.ForanW.ChungT.De BellisM. D.ClarkD. B. (2017). Neural correlates of rewarded response inhibition in youth at risk for problematic alcohol use. Frontiers in Behavioral Neuroscience, 11, Article 205. https://doi.org/10.3389/fnbeh.2017.00205
117.
UddinL. Q. (2015). Salience processing and insular cortical function and dysfunction. Nature Reviews Neuroscience, 16(1), 55–61. https://doi.org/10.1038/nrn3857
WangJ. K. T.AndrewsH.ThukralV. (1992). Presynaptic glutamate receptors regulate noradrenaline release from isolated nerve terminals. Journal of Neurochemistry, 58(1), 204–211. https://doi.org/10.1111/j.1471-4159.1992.tb09297.x
120.
WeissN. H.GoncharenkoS.ForkusS. R.FergusonJ. J.YangM. (2023). Longitudinal investigation of bidirectional relations between childhood trauma and emotion-driven impulsivity in the adolescent brain cognitive development study. Journal of Adolescent Health, 73(4), 731–738. https://doi.org/10.1016/j.jadohealth.2023.05.027
121.
WhitesideS. P.LynamD. R. (2001). The Five Factor Model and impulsivity: Using a structural model of personality to understand impulsivity. Personality and Individual Differences, 30(4), 669–689. https://doi.org/10.1016/S0191-8869(00)00064-7
122.
Whitfield-GabrieliS.Nieto-CastanonA. (2012). Conn: A functional connectivity toolbox for correlated and anticorrelated brain networks. Brain Connectivity, 2(3), 125–141. https://doi.org/10.1089/brain.2012.0073
123.
WilbertzT.DesernoL.HorstmannA.NeumannJ.VillringerA.HeinzeH.-J.BoehlerC. N.SchlagenhaufF. (2014). Response inhibition and its relation to multidimensional impulsivity. NeuroImage, 103, 241–248. https://doi.org/10.1016/j.neuroimage.2014.09.021
124.
WilsonD. J. (2019). The harmonic mean p-value for combining dependent tests. Proceedings of the National Academy of Sciences, 116(4), 1195–1200. https://doi.org/10.1073/pnas.1814092116
125.
WiseR. J.PhungA. L.LabuschagneI.StoutJ. C. (2015). Differential effects of social stress on laboratory-based decision-making are related to both impulsive personality traits and gender. Cognition and Emotion, 29(8), Article 8. https://doi.org/10.1080/02699931.2014.989815
126.
XiaC.TouroutoglouA.QuigleyK. S.Feldman BarrettL.DickersonB. C. (2017). Salience network connectivity modulates skin conductance responses in predicting arousal experience. Journal of Cognitive Neuroscience, 29(5), 827–836. https://doi.org/10.1162/jocn_a_01087
127.
XiaoL.BecharaA.GongQ.HuangX.LiX.XueG.WongS.LuZ.-L.PalmerP.WeiY.JiaY.JohnsonC. A. (2013). Abnormal affective decision making revealed in adolescent binge drinkers using a functional magnetic resonance imaging study. Psychology of Addictive Behaviors, 27(2), Article 2. https://doi.org/10.1037/a0027892
128.
XueG.LuZ.LevinI. P.BecharaA. (2010). The impact of prior risk experiences on subsequent risky decision-making: The role of the insula. NeuroImage, 50(2), Article 2. https://doi.org/10.1016/j.neuroimage.2009.12.097
129.
YarkoniT.PoldrackR. A.NicholsT. E.Van EssenD. C.WagerT. D. (2011). Large-scale automated synthesis of human functional neuroimaging data. Nature Methods, 8(8), 665–670. https://doi.org/10.1038/nmeth.1635
130.
YoungC. B.RazG.EveraerdD.BeckmannC. F.TendolkarI.HendlerT.FernándezG.HermansE. J. (2017). Dynamic shifts in large-scale brain network balance as a function of arousal. The Journal of Neuroscience, 37(2), 281–290. https://doi.org/10.1523/JNEUROSCI.1759-16.2016
131.
YoungS. E.FriedmanN. P.MiyakeA.WillcuttE. G.CorleyR. P.HaberstickB. C.HewittJ. K. (2009). Behavioral disinhibition: Liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. Journal of Abnormal Psychology, 118(1), 117–130. https://doi.org/10.1037/a0014657
132.
ZapolskiT. C. B.CydersM. A.SmithG. T. (2009). Positive urgency predicts illegal drug use and risky sexual behavior. Psychology of Addictive Behaviors, 23(2), 348–354. https://doi.org/10.1037/a0014684
133.
ZapolskiT. C. B.SmithG. T. (2013). Comparison of parent versus child-report of child impulsivity traits and prediction of outcome variables. Journal of Psychopathology and Behavioral Assessment, 35, 301–313. https://doi.org/10.1007/s10862-013-9349-2
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