Wound healing in pediatric patients is affected by physiology, growth, and development considerations unique from those in adults. In the following report, we review the primary literature on aging and wound healing and highlight clinical wound healing applications for the pediatric patient across age ranges from neonates and infants in the first year of life to adolescents (aged 10–19 years by World Health Organization definition).
Recent Advances:
We characterize the differences in wound healing biology between infants, adolescents, and adults and discuss wound care strategies for pediatric surgical patients, highlighting evidence-based guidelines for wound management. We discuss relevant animal models and review the multidisciplinary aspects of providing wound care for children.
Critical Issues:
Pediatric surgical patients have specialized wound care needs. Optimizing wound care outcomes for infants, children, and adolescents relies on an understanding of their wound-healing biology and unique physiological, psychological, and social considerations.
Future Directions:
Future directions in pediatric wound care will focus on validating and optimizing emerging technologies through pediatric-specific clinical trials, while also addressing key knowledge gaps in topical agent pharmacokinetics and advancing regenerative approaches like mesenchymal stem cell therapies tailored to the unique biology of infants and children.
TelofskiLS, MorelloAP, Mack CorreaMC, et al.The infant skin barrier: Can we preserve, protect, and enhance the barrier? Dermatol Res Pract, 2012; 2012:198789; doi: 10.1155/2012/198789
4.
GrattonR, Del VecchioC, ZupinL, et al.Unraveling the role of sex hormones on keratinocyte functions in human inflammatory skin diseases. Int J Mol Sci, 2022; 23(6):3132; doi: 10.3390/ijms23063132
5.
SchneiderAM, NolanZT, BanerjeeK, et al.Evolution of the facial skin microbiome during puberty in normal and acne skin. J Eur Acad Dermatol Venereol, 2023; 37(1):166–175; doi: 10.1111/jdv.18616
6.
SitzmanTJ, VerheyEM, KirschnerRE, et al.; Cleft Outcomes Research NETwork (CORNET) Consortium. Cleft palate repair postoperative management: Current practices in the United States. Cleft Palate Craniofac J, 2024; 61(5):827–833; doi: 10.1177/10556656221146891
7.
ReenaBandyopadhyayKH, PaulA. Postoperative analgesia for cleft lip and palate repair in children. J Anaesthesiol Clin Pharmacol, 2016; 32(1):5–11; doi: 10.4103/0970-9185.175649
8.
NikolovskiJ, StamatasGN, KolliasN, et al.Barrier function and water-holding and transport properties of infant stratum corneum are different from adult and continue to develop through the first year of life. J Invest Dermatol, 2008; 128(7):1728–1736; doi: 10.1038/sj.jid.5701239
9.
StamatasGN, RouxP, Boireau‐AdamezykE, et al.Skin maturation from birth to 10 years of age: Structure, function, composition and microbiome. Exp Dermatol, 2023; 32(9):1420–1429; doi: 10.1111/exd.14843
10.
OrangesT, DiniV, RomanelliM. Skin physiology of the neonate and infant: Clinical implications. Adv Wound Care (New Rochelle), 2015; 4(10):587–595; doi: 10.1177/wound.2015.0642
11.
FairleyJA, RasmussenJE. Comparison of stratum corneum thickness in children and adults. J Am Acad Dermatol, 1983; 8(5):652–654; doi: 10.1016/S0190-9622(83)70074-5
12.
OrssoCE, Colin-RamirezE, FieldCJ, et al.Adipose tissue development and expansion from the womb to adolescence: An overview. Nutrients, 2020; 12(9):2735; doi: 10.3390/nu12092735
13.
ThorntonMJ. Estrogens and aging skin. Dermatoendocrinol, 2013; 5(2):264–270; doi: 10.4161/derm.23872
14.
PorrelloER, MahmoudAI, SimpsonE, et al.Transient regenerative potential of the neonatal mouse heart. Science, 2011; 331(6020):1078–1080; doi: 10.1126/science.1200708
15.
HaubnerBJ, SchneiderJ, SchweigmannU, et al.Functional recovery of a human neonatal heart after severe myocardial infarction. Circ Res, 2016; 118(2):216–221; doi: 10.1161/CIRCRESAHA.115.307017
16.
CohenBJ, DanonD, RothGS. Wound repair in mice as influenced by age and antimacrophage serum. J Gerontol, 1987; 42(3):295–301; doi: 10.1093/geronj/42.3.295
17.
CastilloV, Díaz-AstudilloP, Corrales-OrovioR, et al.Comprehensive Characterization of tissues derived from animals at different regenerative stages: A comparative analysis between fetal and adult mouse skin. Cells, 2023; 12(9):1215; doi: 10.3390/cells12091215
18.
BagoodMD, GallegosAC, Medina LopezAI, et al.Re-Examining the paradigm of impaired healing in the aged murine excision wound model. J Invest Dermatol, 2021; 141(4S):1071–1075.e4; doi: 10.1016/j.jid.2020.10.022
19.
BrubakerAL, RendonJL, RamirezL, et al.Reduced neutrophil chemotaxis and infiltration contributes to delayed resolution of cutaneous wound infection with advanced age. J Immunol, 2013; 190(4):1746–1757; doi: 10.4049/jimmunol.1201213
20.
KimM-H, GorouhiF, RamirezS, et al.Catecholamine stress alters neutrophil trafficking and impairs wound healing by β2-adrenergic receptor–mediated upregulation of IL-6. J Invest Dermatol, 2014; 134(3):809–817; doi: 10.1038/jid.2013.415
21.
KongF, GalzoteC, DuanY. Change in skin properties over the first 10 years of life: A cross-sectional study. Arch Dermatol Res, 2017; 309(8):653–658; doi: 10.1007/s00403-017-1764-x
22.
HarpinVA, RutterN. Barrier properties of the newborn infant’s skin. J Pediatr, 1983; 102(3):419–425; doi: 10.1016/S0022-3476(83)80669-6
23.
LinderN, DavidovitchN, ReichmanB, et al.Topical iodine-containing antiseptics and subclinical hypothyroidism in preterm infants. J Pediatr, 1997; 131(3):434–439; doi: 10.1016/S0022-3476(97)80071-6
24.
HolbrookK. A histologic comparison of infant and adult skin. In: Neonatal Skin: Structure and Function. (MaibachH, BoisitsE. eds) Dekker: New York, NY; 1982; pp. 3–31.
25.
McNamaraSA, HirtPA, WeigeltMA, et al.Traditional and advanced therapeutic modalities for wounds in the paediatric population: An evidence-based review. J Wound Care, 2020; 29(6):321–334; doi: 10.12968/jowc.2020.29.6.321
CuttingK, WhiteR, EdmondsM. The safety and efficacy of dressings with silver—addressing clinical concerns. Int Wound J, 2007; 4(2):177–184; doi: 10.1111/j.1742-481X.2007.00338.x
30.
TropM, NovakM, RodlS, et al.Silver-coated dressing acticoat caused raised liver enzymes and argyria-like symptoms in burn patient. J Trauma, 2006; 60(3):648–652; doi: 10.1097/01.ta.0000208126.22089.b6
ÖzkayaE. A rare case of allergic contact dermatitis from silver nitrate in a widely used special patch test marker. Contact Dermatitis, 2009; 61(2):120–122; doi: 10.1111/j.1600-0536.2009.01566.x
33.
HuntJL, SatoR, HeckEL, et al.A critical evaluation of povidone-iodine absorption in thermally injured patients. J Trauma, 1980; 20(2):127–129; doi: 10.1097/00005373-198002000-00004
34.
CornellRC. Contraindications for using topical steroids. West J Med, 1987; 147(4):459–460.
CruzSA, SteinSL. A review of sports-related dermatologic conditions. Transl Sports Med, 2020; 3(4):300–308; doi: 10.1002/tsm2.145
40.
ShiH, CheerK, SimanainenU, et al.The contradictory role of androgens in cutaneous and major burn wound healing. Burns Trauma, 2021; 9:tkaa046; doi: 10.1093/burnst/tkaa046
41.
BermanL, HronekC, RavalMV, et al.Pediatric gastrostomy tube placement: Lessons learned from high-performing institutions through structured interviews. Pediatr Qual Saf, 2017; 2(2):e016; doi: 10.1097/pq9.0000000000000016
42.
BlumensteinI, ShastriYM, SteinR. Gastroenteric tube feeding: Techniques, problems and solutions. World J Gastroenterol, 2014; 20(26):8505–8524; doi: 10.3748/wjg.v20.i26.8505
43.
DuarteH, SantosC, CapelasML, et al.Peristomal infection after percutaneous endoscopic gastrostomy: A 7-year surveillance of 297 patients. Arq Gastroenterol, 2012; 49(4):255–258; doi: 10.1590/S0004-28032012000400005
44.
BoeykensK, DuysburghI, VerlindenW. Prevention and management of minor complications in percutaneous endoscopic gastrostomy. BMJ Open Gastroenterol, 2022; 9(1):e000975; doi: 10.1136/bmjgast-2022-000975
MellingerJD, SimonIB, SchlechterB, et al.Tract formation following percutaneous endoscopic gastrostomy in an animal model. Surg Endosc, 1991; 5(4):189–191; doi: 10.1007/BF02653261
47.
McClaveSA, DiBaiseJK, MullinGE, et al.ACG clinical guideline: Nutrition therapy in the adult hospitalized patient. Am J Gastroenterol, 2016; 111(3):315–334; quiz 335; doi: 10.1038/ajg.2016.28
48.
ItkinM, DeLeggeMH, FangJC, et al.; Cardiovascular and Interventional Radiological Society of Europe. Multidisciplinary practical guidelines for gastrointestinal access for enteral nutrition and decompression from the Society of Interventional Radiology and American Gastroenterological Association (AGA) Institute, with endorsement by Canadian Interventional Radiological Association (CIRA) and Cardiovascular and Interventional Radiological Society of Europe (CIRSE). J Vasc Interv Radiol, 2011; 22(8):1089–1106; doi: 10.1016/j.jvir.2011.04.006
BoullataJI, CarreraAL, HarveyL, et al.; ASPEN Safe Practices for Enteral Nutrition Therapy Task Force, American Society for Parenteral and Enteral Nutrition. ASPEN safe practices for enteral nutrition therapy. J Parenter Enteral Nutr, 2017; 41(1):15–103; doi: 10.1177/0148607116673053
51.
MassengaA, ChibwaeA, NuriAA, et al.Indications for and complications of intestinal stomas in the children and adults at a tertiary care hospital in a resource-limited setting: A Tanzanian experience. BMC Gastroenterol, 2019; 19(1):157; doi: 10.1186/s12876-019-1070-5
52.
HedrickTL, ShermanA, Cohen-MekelburgS, et al.AGA clinical practice update on management of ostomies: Commentary. Clin Gastroenterol Hepatol, 2023; 21(10):2473–2477; doi: 10.1016/j.cgh.2023.04.035
53.
MillerBT, KrpataDM, PetroCC, et al.Biologic vs synthetic mesh for parastomal hernia repair: Post hoc analysis of a multicenter randomized controlled trial. J Am Coll Surg, 2022; 235(3):401–409; doi: 10.1097/XCS.0000000000000275
GroveG, HouserT, SibbaldG, et al.Measuring epidermal effects of ostomy skin barriers. Skin Res Technol Off J Int Soc Bioeng Skin ISBS Int Soc Digit Imaging Skin ISDIS Int Soc Skin Imaging ISSI, 2019; 25(2):179–186; doi: 10.1111/srt.12630
56.
Forest-LalandeL. Best practice guidelines for ostomy care in neonates, children, and adolescents: An executive summary. J Wound Ostomy Continence Nurs, 2023; 50(5):381–385; doi: 10.1097/WON.0000000000001001
57.
Burgess-StocksJ, GlebaJ, LawrenceK, et al.Ostomy and continent diversion patient bill of rights: Research validation of standards of care. J Wound Ostomy Continence Nurs, 2022; 49(3):251–260; doi: 10.1097/WON.0000000000000876
58.
WooKY, SibbaldRG, AyelloEA, et al.Peristomal skin complications and management. Adv Skin Wound Care, 2009; 22(11):522–532; quiz 533–534; doi: 10.1097/01.ASW.0000305497.15768.cb
59.
Collado-BoiraE, Boldo-RodaP, Bernat-AdellMD, et al.Effectiveness of semiocclusive sodium carboxymethyl cellulose fibers and hydrocolloid dressings for irritant peristomal dermatitis: A case series. Adv Skin Wound Care, 2021; 34(9):493–497; doi: 10.1097/01.ASW.0000767336.91651.67
60.
GilpinV, MageeN, ScottC, et al.Evolution of ostomy pouch design: Opportunities for composite technologies to advance patient care. J Compos Sci, 2024; 8(10):388; doi: 10.3390/jcs8100388
61.
WilliamsJ, GwillamB, SutherlandN, et al.Evaluating skin care problems in people with stomas. Br J Nurs, 2010; 19(17):S6–S15; doi: 10.12968/bjon.2010.19.Sup7.78569
LeeSL, BeyerTD, KimSS, et al.Initial nonoperative management and delayed closure for treatment of giant omphaloceles. J Pediatr Surg, 2006; 41(11):1846–1849; doi: 10.1016/j.jpedsurg.2006.06.011
65.
AlmondS, ReynaR, BarganskiN, et al.Nonoperative management of a giant omphalocele using a silver impregnated hydrofiber dressing: A case report. J Pediatr Surg, 2010; 45(7):1546–1549; doi: 10.1016/j.jpedsurg.2010.03.035
66.
EinSH, LangerJC. Delayed management of giant omphalocele using silver sulfadiazine cream: An 18-year experience. J Pediatr Surg, 2012; 47(3):494–500; doi: 10.1016/j.jpedsurg.2011.08.014
67.
NuchternJG, BaxterR, HatchEI. Nonoperative initial management versus silon chimney for treatment of giant omphalocele. J Pediatr Surg, 1995; 30(6):771–776; doi: 10.1016/0022-3468(95)90745-9
68.
PercyDB, HaddockC, MaV, et al.Dressed for success? Silver impregnated nanocrystalline dressing for initial treatment of giant omphalocele. J Pediatr Surg, 2018; 53(5):905–908; doi: 10.1016/j.jpedsurg.2018.02.005
CarnaghanH, RobertsT, SaveryD, et al.Novel exomphalos genetic mouse model: The importance of accurate phenotypic classification. J Pediatr Surg, 2013; 48(10):2036–2042; doi: 10.1016/j.jpedsurg.2013.04.010
71.
SlidellMB, McAteerJ, MiniatiD, et al.Management of gastroschisis: Timing of delivery, antibiotic usage, and closure considerations (A Systematic Review From the American Pediatric Surgical Association Outcomes & Evidence Based Practice Committee). J Pediatr Surg, 2024; 59(8):1408–1417; doi: 10.1016/j.jpedsurg.2024.03.044
72.
FerreiraRG, MendonçaCR,G, RamosLL, et al.Gastroschisis: A systematic review of diagnosis, prognosis and treatment. J Matern Fetal Neonatal Med, 2022; 35(25):6199–6212; doi: 10.1080/14767058.2021.1909563
73.
GrabskiDF, HuY, VavolizzaRD, et al.Sutureless closure: A versatile treatment for the diverse presentations of gastroschisis. J Perinatol, 2019; 39(5):666–672; doi: 10.1038/s41372-019-0321-1
74.
RibohJ, AbrajanoCT, GarberK, et al.Outcomes of sutureless gastroschisis closure. J Pediatr Surg, 2009; 44(10):1947–1951; doi: 10.1016/j.jpedsurg.2009.03.027
75.
FraserJD, DeansKJ, FallatME, et al.; Midwest Pediatric Surgery Consortium. Sutureless vs sutured abdominal wall closure for gastroschisis: Operative characteristics and early outcomes from the Midwest Pediatric Surgery Consortium. J Pediatr Surg, 2020; 55(11):2284–2288; doi: 10.1016/j.jpedsurg.2020.02.017
76.
SandlerA, LawrenceJ, MeehanJ, et al.A “Plastic” sutureless abdominal wall closure in gastroschisis. J Pediatr Surg, 2004; 39(5):738–741; doi: 10.1016/j.jpedsurg.2004.01.040
77.
VelardeF, CastañedaV, MoralesE, et al.Use of human umbilical cord and its byproducts in tissue regeneration. Front Bioeng Biotechnol, 2020; 8:117; doi: 10.3389/fbioe.2020.00117
78.
OrionKC, KreinM, LiaoJ, et al.Outcomes of plastic closure in gastroschisis. Surgery, 2011; 150(2):177–185; doi: 10.1016/j.surg.2011.05.001
79.
GabrielA, GollinG. Management of complicated gastroschisis with porcine small intestinal submucosa and negative pressure wound therapy. J Pediatr Surg, 2006; 41(11):1836–1840; doi: 10.1016/j.jpedsurg.2006.06.050
80.
WittRG, ZobelM, PadillaB, et al.Evaluation of clinical outcomes of sutureless vs sutured closure techniques in gastroschisis repair. JAMA Surg, 2019; 154(1):33–39; doi: 10.1001/jamasurg.2018.3216
81.
Correia-PintoJ, TavaresML, BaptistaMJ, et al.A new fetal rat model of gastroschisis: Development and early characterization. J Pediatr Surg, 2001; 36(1):213–216; doi: 10.1053/jpsu.2001.20057
82.
FanG, YaoG. Analysis of the efficacy of laparoscopic high hernia sac ligation in adolescent indirect hernia. BMC Surg, 2023; 23(1):160; doi: 10.1186/s12893-023-02048-w
83.
CrissCN, GishN, GishJ, et al.Outcomes of adolescent and young adults receiving high ligation and mesh repairs: A 16-year experience. J Laparoendosc Adv Surg Tech A, 2018; 28(2):223–228; doi: 10.1177/lap.2017.0511
84.
BrunsNE, GlennIC, McNinchNL, et al.Treatment of routine adolescent inguinal hernia vastly differs between pediatric surgeons and general surgeons. Surg Endosc, 2017; 31(2):912–916; doi: 10.1007/s00464-016-5054-z
85.
TaylorMA, CutshallZA, EldredgeRS, et al.High ligation in adolescents: Is it enough? J Pediatr Surg, 2021; 56(10):1865–1869; doi: 10.1016/j.jpedsurg.2020.11.006
86.
KimSH, JungHS, ParkS, et al.Inguinal hernia repair with or without mesh in late adolescent males. Ann Surg Treat Res, 2021; 100(4):246–251; doi: 10.4174/astr.2021.100.4.246
87.
MorgadoM, HollandAJ. Inguinal hernias in children: Update on management guidelines. J Paediatr Child Health, 2024; 60(11):648–653; doi: 10.1111/jpc.16677
88.
FaurschouIK, ErichsenR, DollD, et al.Time trends in incidence of pilonidal sinus disease from 1996 to 2021: A Danish population-based cohort study. Colorectal Dis, 2024; 27(1):e17227; doi: 10.1111/codi.17227
89.
LiangNE, AbrajanoC, JoS, et al.Guidelines for wound care considerations in pilonidal disease: Lessons learned from a Pilonidal Treatment Clinic. J Pediatr Surg, 2025; 60(5):162247; doi: 10.1016/j.jpedsurg.2025.162247
90.
JohnsonEK, VogelJD, CowanML, et al.; Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons. The American Society of Colon and Rectal Surgeons’ Clinical Practice Guidelines for the management of pilonidal disease. Dis Colon Rectum, 2019; 62(2):146–157; doi: 10.1097/DCR.0000000000001237
91.
PutnisS, KhanWS, WongJM-L. Negative pressure wound therapy—a review of its uses in orthopaedic trauma. Open Orthop J, 2014; 8:142–147; doi: 10.2174/1874325001408010142
92.
RouchJD, KeeleyJA, ScottA, et al.Short- and long-term results of unroofing and marsupialization for adolescent pilonidal disease. JAMA Surg, 2016; 151(9):877–879; doi: 10.1001/jamasurg.2016.0850
93.
MassonR, MaE, ParvathalaN, et al.Efficacy of medical treatments for pediatric hidradenitis suppurativa: A systematic review. Pediatr Dermatol, 2023; 40(5):775–788; doi: 10.1111/pde.15404
94.
SalihAM, RahimHM, AbdallaBA, et al.Trial of pilonidal sinus disease induction in a rat model: An animal experimental study. Barw Med J, 2023; doi: 10.58742/bmj.v1i1.9
95.
AlikhanA, LynchPJ, EisenDB. Hidradenitis suppurativa: A comprehensive review. J Am Acad Dermatol, 2009; 60(4):539–561; doi: 10.1016/j.jaad.2008.11.911
96.
CottonCH, ChenSX, HussainSH, et al.Hidradenitis suppurativa in pediatric patients. Pediatrics, 2023; 151(5):e2022061049; doi: 10.1542/peds.2022-061049
97.
SachdevaM, KimP, MuftiA, et al.Biologic use in pediatric patients with hidradenitis suppurativa: A systematic review. J Cutan Med Surg, 2022; 26(2):176–180; doi: 10.1177/12034754211049711
98.
AttingerC, WolcottR. Clinically addressing biofilm in chronic wounds. Adv Wound Care (New Rochelle), 2012; 1(3):127–132; doi: 10.1089/wound.2011.0333
99.
RingHC, BayL, NilssonM, et al.Bacterial biofilm in chronic lesions of hidradenitis suppurativa. Br J Dermatol, 2017; 176(4):993–1000; doi: 10.1111/bjd.15007
100.
PatelKF, Rodríguez-MercedesSL, GrantGG, et al.Physical, psychological, and social outcomes in pediatric burn survivors ages 5 to 18 years: A systematic review. J Burn Care Res, 2022; 43(2):343–352; doi: 10.1093/jbcr/irab225
101.
WoolardA, HillNTM, McQueenM, et al.The psychological impact of paediatric burn injuries: A systematic review. BMC Public Health, 2021; 21(1):2281; doi: 10.1186/s12889-021-12296-1
102.
CuttleL, FearM, WoodFM, et al.Management of non-severe burn wounds in children and adolescents: Optimising outcomes through all stages of the patient journey. Lancet Child Adolesc Health, 2022; 6(4):269–278; doi: 10.1016/S2352-4642(21)00350-3
103.
HarishV, LiZ, MaitzPKM. First aid is associated with improved outcomes in large body surface area burns. Burns, 2019; 45(8):1743–1748; doi: 10.1016/j.burns.2019.05.006
104.
GriffinBR, FrearCC, BablF, et al.Cool running water first aid decreases skin grafting requirements in pediatric burns: A cohort study of two thousand four hundred ninety-five children. Ann Emerg Med, 2020; 75(1):75–85; doi: 10.1016/j.annemergmed.2019.06.028
105.
SumanA, OwenJ. Update on the management of burns in paediatrics. BJA Educ, 2020; 20(3):103–110; doi: 10.1016/j.bjae.2019.12.002
106.
SharmaR, ParasharA. Special considerations in paediatric burn patients. Indian J Plast Surg, 2010; 43(Suppl):S43–S50; doi: 10.4103/0970-0358.70719
107.
KingA, BalajiS, KeswaniSG. Biology and function of fetal and pediatric skin. Facial Plast Surg Clin North Am, 2013; 21(1):1–6; doi: 10.1016/j.fsc.2012.10.001
108.
HettiaratchyS, PapiniR. Initial management of a major burn: II—assessment and resuscitation. Bmj, 2004; 329(7457):101–103; doi: 10.1136/bmj.329.7457.101
109.
MurariA, SinghKN. Lund and Browder chart—modified versus original: A comparative study. Acute Crit Care, 2019; 34(4):276–281; doi: 10.4266/acc.2019.00647
110.
JeschkeMG, Van BaarME, ChoudhryMA, et al.Burn injury. Nat Rev Dis Primers, 2020; 6(1):11; doi: 10.1038/s41572-020-0145-5
111.
KhatibM, JabirS, Fitzgerald O’ConnorE, et al.A systematic review of the evolution of laser Doppler techniques in burn depth assessment. Plast Surg Int, 2014; 2014:621792–621713; doi: 10.1155/2014/621792
112.
MillJ, CuttleL, HarkinDG, et al.Laser Doppler imaging in a paediatric burns population. Burns, 2009; 35(6):824–831; doi: 10.1016/j.burns.2008.11.016
113.
NhereraLM, TruemanP, RobertsCD, et al.A systematic review and meta-analysis of clinical outcomes associated with nanocrystalline silver use compared to alternative silver delivery systems in the management of superficial and deep partial thickness burns. Burns, 2017; 43(5):939–948; doi: 10.1016/j.burns.2017.01.004
114.
FrearCC, CuttleL, McPhailSM, et al.Randomized clinical trial of negative pressure wound therapy as an adjunctive treatment for small-area thermal burns in children. Br J Surg, 2020; 107(13):1741–1750; doi: 10.1002/bjs.11993
Roth BettlachCL, BerghegerC, JacobsonL, et al.Treatment of pediatric upper extremity burns. J Nurse Pract, 2023; 19(3):104536; doi: 10.1016/j.nurpra.2022.104536
117.
BaroneN, SafranT, VorstenboschJ, et al.Current advances in hypertrophic scar and keloid management. Semin Plast Surg, 2021; 35(3):145–152; doi: 10.1055/s-0041-1731461
118.
ThompsonDM, ThomasC, HydeL, et al.At home parent-administered dressing changes in paediatric burns aftercare: Interviews on parents’ experiences of treatment. Burns, 2022; 48(2):355–364; doi: 10.1016/j.burns.2021.06.005
119.
KentL, KingH, CochraneR. Maternal and child psychological sequelae in paediatric burn injuries. Burns, 2000; 26(4):317–322; doi: 10.1016/S0305-4179(99)00172-2
120.
BerthelsenD, HayesN, WhiteSLJ, et al.Executive function in adolescence: Associations with child and family risk factors and self-regulation in early childhood. Front Psychol, 2017; 8:903; doi: 10.3389/fpsyg.2017.00903
121.
Kelley-QuonLI, KirkpatrickMG, RiccaRL, et al.Guidelines for opioid prescribing in children and adolescents after surgery: An expert panel opinion. JAMA Surg, 2021; 156(1):76–90; doi: 10.1001/jamasurg.2020.5045
122.
DuongTA, GleasonLT, KichlerK, et al.Improving surgical patient education materials using informational design with visual elements. Am J Surg, 2022; 224(6):1497–1500; doi: 10.1016/j.amjsurg.2022.08.009
123.
SuluhanD, YildizD, SurerI, et al.Effect of gastrostomy tube feeding education on parents of children with gastrostomy. Nutr Clin Pract, 2021; 36(6):1220–1229; doi: 10.1002/ncp.10586
124.
RobertsR, BurdallO, BohrC, et al.; National Stoma Study Research Collaborative. Are we informing our patients correctly? Evaluation of perioperative counselling for paediatric intestinal stoma formation: A national study. Pediatr Surg Int, 2024; 40(1):189; doi: 10.1007/s00383-024-05756-3
125.
CiogaE, CruzD, LaranjeiraC. Parental adjustment to a burn-injured child: How to support their needs in the aftermath of the injury. Front Psychol, 2024; 15:1456671; doi: 10.3389/fpsyg.2024.1456671
126.
SinghH, MorrisonM, McIltrotK. Education following pediatric gastrostomy tube placement: An integrative review. J Pediatr Nurs, 2021; 61:387–393; doi: 10.1016/j.pedn.2021.09.015
127.
BaharestaniMM. An overview of neonatal and pediatric wound care knowledge and considerations. Ostomy Wound Manage, 2007; 53(6):34–36, 38, 40, passim.
128.
CaccavaleS, TancrediV, BoccellinoMP, et al.Hidradenitis suppurativa burdens on mental health: A literature review of associated psychiatric disorders and their pathogenesis. Life (Basel), 2023; 13(1):189; doi: 10.3390/life13010189
129.
RussoK. Assessment and treatment of adolescents with chronic medical conditions. J Health Serv Psychol, 2022; 48(2):69–78; doi: 10.1007/s42843-022-00059-4
130.
DoctorN, YangS, MaerzackerS, et al.Socioeconomic status and outcomes after burn injury. J Burn Care Res, 2016; 37(1):e56–e62; doi: 10.1097/BCR.0000000000000327
131.
BaldacciS, SantoroM, CoiA, et al.Lifestyle and sociodemographic risk factors for gastroschisis: A systematic review and meta-analysis. Arch Dis Child, 2020; 105(8):756–764; doi: 10.1136/archdischild-2019-318412
132.
ColquittL, BurjonrappaS. The relationship between socioeconomic status and omphalocele prevalence. J Pediatr Surg, 2025; 60(4):162225; doi: 10.1016/j.jpedsurg.2025.162225
133.
YapA, LaverdeR, ThompsonA, et al.Social vulnerability index (SVI) and poor postoperative outcomes in children undergoing surgery in California. Am J Surg, 2023; 225(1):122–128; doi: 10.1016/j.amjsurg.2022.09.030
134.
GutierrezSA, PathakS, RaghuV, et al.Neighborhood income is associated with health care use in pediatric short bowel syndrome. J Pediatr, 2024; 265:113819; doi: 10.1016/j.jpeds.2023.113819
135.
MphandeANG, KilloweC, PhaliraS, et al.Effects of honey and sugar dressings on wound healing. J Wound Care, 2007; 16(7):317–319; doi: 10.12968/jowc.2007.16.7.27053
136.
Bianciardi ValassinaMF, BellaS, MurgiaF, et al.Telemedicine in pediatric wound care. Clin Ter, 2016; 167(1):e21–e23; doi: 10.7417/T.2016.1915
137.
SwihartDL, YarrarapuSNS, MartinRL. Cultural religious competence in clinical practice. In: StatPearls. StatPearls Publishing: Treasure Island (FL); 2025.
OkoniewskiW, SundaramM, Chaves-GneccoD, et al.Culturally sensitive interventions in pediatric primary care settings: A systematic review. Pediatrics, 2022; 149(2):e2021052162; doi: 10.1542/peds.2021-052162
140.
MahleWT, NicolsonSC, Hollenbeck-PringleD, et al.; Pediatric Heart Network Investigators. Utilizing a collaborative learning model to promote early extubation following infant heart surgery. ∗Pediatr Crit Care Med, 2016; 17(10):939–947; doi: 10.1097/PCC.0000000000000918
141.
CirilloMD, MirdellR, SjöbergF, et al.Improving burn depth assessment for pediatric scalds by AI based on semantic segmentation of polarized light photography images. Burns, 2021; 47(7):1586–1593; doi: 10.1016/j.burns.2021.01.011
142.
TottyJP, BuaN, SmithGE, et al.Dialkylcarbamoyl chloride (DACC)-coated dressings in the management and prevention of wound infection: A systematic review. J Wound Care, 2017; 26(3):107–114; doi: 10.12968/jowc.2017.26.3.107
143.
CiprandiG, CrucianelliS, GrussuF, et al.Meeting the challenges in pediatric wound care: Our 15-year experience with Dialkylcarbamoyl Chloride-coated dressing technology in acute and chronic wounds. Cwcmr, 2022; 9:23–33; doi: 10.2147/CWCMR.S376889
144.
PedrazziNE, NaikenS, La ScalaG. Negative pressure wound therapy in pediatric burn patients: A systematic review. Adv Wound Care (New Rochelle), 2021; 10(5):270–280; doi: 10.1089/wound.2019.1089
145.
StriogaM, ViswanathanS, DarinskasA, et al.Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. Stem Cells Dev, 2012; 21(14):2724–2752; doi: 10.1089/scd.2011.0722
PelizzoG, AvanziniMA, Icaro CornagliaA, et al.Mesenchymal stromal cells for cutaneous wound healing in a rabbit model: Pre-clinical study applicable in the pediatric surgical setting. J Transl Med, 2015; 13(1):219; doi: 10.1186/s12967-015-0580-3
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