This is a case report of a 47-year-old woman with known Long QT Syndrome who was given GnRH analogues to induce menopause prior to hysterectomy for fibroids who suffered several episodes of ventricular fibrillation leading to Torsades de Pointes cardiac arrests. This paper discusses the case and the physiological backdrop of hormone influences on the QT interval in women, includes the patient perspective and makes recommendations.
DahlbergPDiamantU-BGilljamT, et al.QT correction using Bazett’s formula remains preferable in long QT syndrome type 1 and 2. Ann Noninvasive Electrocardiol2021; 26: e12804.
RezuşCMogaVDOuatuA, et al.QT interval variations and mortality risk: is there any relationship?Anatol J Cardiol2015; 15: 255–258.
4.
Díez-EscutéNArbeloEMartínez-BarriosE, et al.Sex differences in long QT syndrome. Front Cardiovasc Med2023; 10: 1164028.
5.
GökçeMKarahanBYilmazR, et al.Long term effects of hormone replacement therapy on heart rate variability, QT interval, QT dispersion and frequencies of arrhythmia. Int J Cardiol2005; 99: 373–379.
6.
ZaitoonHKapustaLIsraeliG, et al. QT interval changes in transgender/gender diverse adolescents receiving gonadotropin-releasing hormone agonist and gender-affirming hormonal treatment. Int J Transgend Health. 2025; 1–12.
7.
GoldenbergIYounisAHuangDT, et al.Use of oral contraceptives in women with congenital long QT syndrome. Heart Rhythm2022; 19: 41–48.
