Renal cell carcinoma has an unpredictable course with a propensity for metastatic spread. Here we present the case of a female patient with an unusual presentation of metastatic renal cell carcinoma to the eyelid which is extremely rare. Treatment of metastatic renal cell carcinoma is still controversial; however, several authors consider metastasectomy to be a valid option. Unfortunately, little information is available on the utility of systemic treatment after the complete resection of metastatic lesions.
Level of evidence: Not applicable for this multicentre audit.
SiegelRLMillerKDJemalA.Cancer statistics, 2018. CA Cancer J Clin2018; 68: 7–30.
2.
BianchiMSunMJeldresC, et al. Distribution of metastatic sites in renal cell carcinoma: a population-based analysis. Ann Oncol2012; 23: 973–980.
3.
SountoulidesPMetaxaLCindoloL.Atypical presentations and rare metastatic sites of renal cell carcinoma: a review of case reports. J Med Case Rep2011; 5: 429.
4.
TailorRInksterCHansonI, et al. Metastatic renal cell carcinoma presenting as a chalazion. Eye2007; 21: 564–565.
5.
GonzalezFAbalo-LojoJMSuarez-PeñarandaJM, et al. Eyelid metastasis as the initial presentation of a renal cell carcinoma. Urology2015; 85: 35–36.
6.
Cabrera-BeyroutiRCampos-MolloERico-SantosE, et al. Eyelid metastasis as first presentation of renal cell carcinoma. Arch Soc Esp Oftalmol2017; 92: 547–551.
7.
AntonelliAArrighiNCortiS, et al. Surgical treatment of atypical metastasis from renal cell carcinoma (RCC). BJU Int2012; 110: 559–563.
8.
AltALBoorjianSALohseCM, et al. Survival after complete surgical resection of multiple metastases from renal cell carcinoma. Cancer2011; 117: 2873–2882.
9.
VoglUMZehetgruberHDominkusM, et al. Prognostic factors in metastatic renal cell carcinoma: metastasectomy as independent prognostic variable. Br J Cancer2006; 95: 691–698.
10.
ThyavihallyYBMahantshettyUChamarajanagarRS, et al. Management of renal cell carcinoma with solitary metastasis. World J Surg Oncol2005; 3: 48.
11.
KwakCParkYHJeongCW, et al. Metastasectomy without systemic therapy in metastatic renal cell carcinoma: comparison with conservative treatment. Urol Int2007; 79: 145–151.
12.
ParkYHJungJWLeeBK, et al. Targeted therapy after complete resection of metastatic lesions in metastatic renal cell carcinoma. Int J Urol2015; 22: 153–157.
13.
ParkILeeJLAhnJH, et al. Active surveillance for metastatic or recurrent renal cell carcinoma. J Cancer Res Clin Oncol2014; 140: 1421–1428.
14.
RiniBIDorffTBElsonP, et al. Active surveillance in metastatic renal-cell carcinoma: a prospective, phase 2 trial. Lancet Oncol2016; 17: 1317–1324.
15.
IvanyiPEggersHSeidelCA, et al. Active surveillance (AS) in the management of patients (pts) with metastatic renal cell carcinoma (mRCC). J Clin Oncol2016; 34 (15 Suppl.): e16070.
