Burning mouth syndrome is a form of chronic orofacial pain with an unclear but likely multifactorial aetiology with potential involvement of the central and peripheral nervous systems. No mucosal abnormalities are found on examination, and the diagnosis is one of exclusion. Potential management strategies may include use of topical medication, systemic medication, physical barriers, or psychological therapy. General dental practitioners may be one of the first health care professionals that patients will present to and therefore their role is seen as significant in the patient pathway. This article provides an overview for general dental practitioners on their role in the diagnosis and management of burning mouth syndrome.
AravindhanAVidyalakshmiSSiva KumarM, et al. Burning mouth syndrome: A review on its diagnostic and therapeutic approach. J Pharm Bioallied Sci. 2014;6(S1):S21-S25.
International Headache Society (IHS). International Classification of Orofacial Pain, 1st Edition (ICOP). Cephalalgia. 2020;40(2):129-221.
4.
TanHLRentonT. Burning mouth syndrome: An update. Cephalalgia Rep. 2020;3.
5.
National Institute of Dental and Craniofacial Research (NIDCR), US National Institutes of Health (NIH). Burning Mouth Syndrome. [Internet]. Bethesda, MD, USA: NIDCR; 2023. (NIH Publication No. 23-6288.) Available at nidcr.nih.gov/sites/default/files/2023-12/burning-mouth-syndrome.pdf [Accessed May 2025].
6.
TanHLSmithJGHoffmannJ, et al. A systematic review of treatment for patients with burning mouth syndrome. Cephalalgia. 2022;42(2):128-161.
7.
SuarezPClarkGT. Burning mouth syndrome: An update on diagnosis and treatment methods. J Calif Dent Assoc. 2006;34(8):611-622.
8.
Nasri-HeirCZaguryJGThomasD, et al. Burning mouth syndrome: Current concepts. J Indian Prosthodont Soc. 2015Oct-Dec;15(4):300-307.
9.
MaltaCENCostaFWGDiasCC, et al. Association of anxiety, depression, and stress with burning mouth syndrome: a case-control study. Gen Dent. 2021;69(4):46-52.
PereiraJVNormandoAGCRodrigues-FernandesCI, et al. The impact on quality of life in patients with burning mouth syndrome: A systematic review and meta-analysis. Oral Surg Oral Med Oral Pathol Oral Radiol. 2021;131(2):186-194.
12.
YilmazZRentonTYiangouY, et al. Burning mouth syndrome as a trigeminal small fibre neuropathy: Increased heat and capsaicin receptor TRPV1 in nerve fibres correlates with pain score. J Clin Neurosci. 2007;14(9):864-871.
13.
O’NeilFMarshallAFerdousiM, et al. Corneal Confocal Microscopy Detects Small-Fiber Neuropathy in Burning Mouth Syndrome. J Oral Facial Pain Headache. 2019;33(3):337-341.
14.
ForssellHJääskeläinenSTenovuoO, et al. Sensory dysfunction in burning mouth syndrome. Pain. 2002;99(1-2): 41-47.
15.
JääskeläinenSForssellHTenovuoO. Abnormalities of the blink reflex in burning mouth syndrome. Pain. 1997;73(3):455-460.
GrushkaMEpsteinJBGorskyM. Burning mouth syndrome. Am Fam Physician. 2002;65(4):615-620.
18.
BraudADescroixVUngeheuerMN, et al. Taste function assessed by electrogustometry in burning mouth syndrome: a case-control study. Oral Dis. 2017;23(3):395-402.
19.
EliavEKamranBSchahamR, et al. Evidence of chorda tympani dysfunction in patients with burning mouth syndrome. J Am Dent Assoc. 2007;138(5):628-633.
López-JornetPColladoYZambudioA, et al. Chemosensory Function in Burning Mouth Syndrome a Comparative Cross-Sectional Study. Nutrients. 2021;13(3):722.
22.
TanYWuXChenJ, et al. Structural and Functional Connectivity Between the Amygdala and Orbital Frontal Cortex in Burning Mouth Syndrome: An fMRI Study. Front Psychol. 2019:10:1700.
23.
AdamoDCanforaFCalabriaE, et al. White matter hyperintensities in Burning Mouth Syndrome assessed according to the Age-Related White Matter Changes scale. Front Aging Neurosci. 2022:14:923720.
24.
JääskeläinenSKRinneJOForssellH, et al. Role of the dopaminergic system in chronic pain - a fluorodopa-PET study. Pain. 2001;90(3):257-260.
25.
TaiminenTKuusaloLLehtinenL, et al. Psychiatric (axis I) and personality (axis II) disorders in patients with burning mouth syndrome or atypical facial pain. Scand J Pain. 2011;2(4):155-160.
26.
ZigmondASSnaithRP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67(6):361-370.
27.
OsailanSPramanikRShirodariaS, et al. Investigating the relationship between hyposalivation and mucosal wetness. Oral Dis. 2011;17(1):109-114.
HumphrisGMLongmanLPFieldEA. Cognitive-behavioural therapy for idiopathic burning mouth syndrome: a report of two cases. Br Dent J. 1996;181(6):204-208.
30.
BergdahlJAnnerothGPerrisH. Cognitive therapy in the treatment of patients with resistant burning mouth syndrome: a controlled study. J Oral Pathol Med. 1995;24(5):213-215.
SardellaAUgliettiDDemarosiF, et al. Benzydamine hydrochloride oral rinses in management of burning mouth syndrome. A clinical trial. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1999;88(6):683-686.
33.
Gremeau-RichardCWodaANavezML, et al. Topical clonazepam in stomatodynia: a randomised placebo-controlled study. Pain. 2004;108(1-2):51-57.
34.
GramacyAVillaA. Topical gabapentin solution for the management of burning mouth syndrome: A retrospective study. PLoS One. 2023;18(12):e0295559.
35.
López-JornetPCamacho-AlonsoFAndujar-MateosP. A prospective, randomized study on the efficacy of tongue protector in patients with burning mouth syndrome. Oral Dis. 2011;17(3):277-282.
36.
GonçalvesDRBotelhoLMCarrardVC, et al. Amitriptyline effectiveness in burning mouth syndrome: An in-depth case series analysis. Gerodontology. 2024;41(4):547-554.
37.
Tammiala-SalonenTForssellH. Trazodone in burning mouth pain: a placebo-controlled, double-blind study. J Orofac Pain. 1999;13(2):83-88.
38.
MainaGVitalucciAGandolfoS, et al. Comparative efficacy of SSRIs and amisulpride in burning mouth syndrome: a single-blind study. J Clin Psychiatry. 2002;63(1):38-43.
39.
YamazakiYHataHKitamoriS, et al. An open-label, noncomparative, dose escalation pilot study of the effect of paroxetine in treatment of burning mouth syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009;107(1):e6-11.
40.
PakfetratATalebiMDalirsaniZ, et al. Evaluation of the effectiveness of crocin isolated from saffron in treatment of burning mouth syndrome: A randomized controlled trial. Avicenna J Phytomed. 2019;9(6):505-516.
41.
López-D'alessandroEEscovichL. Combination of alpha lipoic acid and gabapentin, its efficacy in the treatment of Burning Mouth Syndrome: a randomized, double-blind, placebo controlled trial. Med Oral Patol Oral Cir Bucal. 2011;16(5):e635-640.
42.
FemianoFScullyC. Burning mouth syndrome (BMS): double blind controlled study of alpha-lipoic acid (thioctic acid) therapy. J Oral Pathol Med. 2002;31(5):267-269.
43.
McMillanRForssellHBuchananJA, et al. Interventions for treating burning mouth syndrome. Cochrane Database Syst Rev. 2016. Issue 11. Art. No.: CD002779.
