YusufSPetoRLewisJCollinsRSleightP. Beta blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis1985; XXVII: 335–371.
2.
PackerMBristowMRCohnJNColucciWSFowlerMBGilbertEMfor the USA Carvedilol Heart Failure Study Group. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med1996; 334: 1349–1355.
3.
SwedbergKHeldPKjekshusJRasmussenKRydénLWedelH. Effects of the early administration of enalapril on mortality in patients with acute myocardial infarction: results of the Cooperative New Scandinavian Enalapril Survival Study II (CONSENSUS II). N Engl J Med1992; 327: 678–684.
4.
HerlitzJHolmbergSPennertKSwedbergKVedinAWaagsteinFGöteborg Metoprolol Trial: patient characteristics and conduct. Am J Cardiol1984; 53: 3D–8D.
5.
The MIAMI trial research group. Metoprolol in acute myocardial infarction (MIAMI). A randomized placebo-controlled international trial. Eur Heart J1985;6: 199–226.
LechatPEscolanoSGolmardJLLardouxHWitchitzSHennemanJAPrognostic value of bisoprolol-induced hemodynamic effects in heart failure during the cardiac insufficiency bisoprolol study (CIBIS). Circulation1997;96: 2197–2205. References [7,34–37] are publications of clinical studies on the effect of β-blockers on patients with left ventricular dysfunction. The results are controversial. Administration of the ‘pure β-blocker’ bisoprolol had no effect on left ventricular volume for 46% of patients who had had heart failure of ischaemic aetiology. In contrast, in three studies in which 100% of patients had had heart failure of ischaemic aetiology and vasodilator β-blockers (bucindolol and carvedilol) were used, left ventricular dilatation was prevented or a tendency towards a smaller left ventricular volume was achieved. Since authors of these articles do not report pressure–volume relationships, it might well be that reduction of loading shifted the volume towards apparently smaller volumes extrapolated from the pressure–volume curve without there being a true structural reduction of volume. Only the latter can be considered an effect on remodelling. Although these reports concern all the clinical data thus far available, they do not prove that administration of β-blockers has an effect on remodelling.
8.
FrancisGSBenedictCJohnstoneDEKirlinPCNicklasJLiangCSComparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure: substudy of the Studies of Left Ventricular Dysfunction (SOLVD). Circulation1990; 82: 1724–1729.
9.
BenedictCRSheltonBJohnstoneDEFrancisGGreenbergBKonstamMPrognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction. Circulation1996; 94: 690–697.
10.
FraccarolloDHuKGaluppoPGaudronPErtlG. Chronic endothelin receptor blockade attenuates progressive ventricular dilation and improves cardiac function in rats with myocardial infarction. Possible involvement of myocardial endothelin system in ventricular remodeling. Circulation1997; 96: 3963–3973.
11.
HodsmanGPKohzukiMHowesLGSumithranETsunodaKJohnstonCI. Neurohumoral responses to chronic myocardial infarction in rats. Circulation1988; 78: 376–381.
12.
HowesLGHodsmanGPMaccaroneCKohzukiMJohnstonCI. Cardiac 3,4-dihydroxyphenylethylene glycol (DHPG) and catecholamine levels in a rat model of left ventricular failure. J Cardiovasc Pharmacol1989; 13: 348–352.
HeilbrunnSMShahPBristowMRValantineHAGinsburgRFowlerMB. Increased β-receptor density and improved hemodynamic response to catecholamine stimulation during long-term metoprolol therapy in heart failure from dilated cardiomyopathy. Circulation1989; 79: 483–490.
15.
SteinbergSFZhangHLPakEPagnottaGBoydenPA. Characteristics of the β-adrenergic receptor complex in the epicardial border zone of the 5-day infarcted canine heart. Circulation1995; 91: 2824–2833.
16.
FelleniusEHansenCAMiøsONeelyAJR. Chronic infarction decreases maximum cardiac work and sensitivity of heart to extracellular calcium. Am J Physiol1985; 249: H80–H87.
17.
ItayaTHashimotoHUematsuTNakashimaM. Alterations of responsiveness to adrenoceptor agonists and calcium of non-infarcted hypertrophied muscles from rats with chronic myocardial infarction. Br J Pharmacol1990; 99: 572–576.
18.
GengoPJSabbahHNSteffenRPSharpeJKKonoTSteinPDMyocardial beta-adrenoceptor and voltage sensitive calcium channel changes in a canine model of chronic heart failure. J Mol Cell Cardiol1992;24: 1361–1369.
19.
HochmanJSWongSC. Effect of atenolol on myocardial infarct expansion in a nonreperfused rat model. Am Heart J1991; 122: 689–694. See annotation [21].
20.
FishbeinMLeiLQRubinSA. Long-term propranolol administration alters myocyte and ventricular geometry in rat hearts with and without infarction. See annotation [21].
21.
OhBHOnoSGilpsinERossJ. Altered left ventricular remodeling with β-adrenergic blockade and exercise after coronary reperfusion in rats. Circulation1993; 87: 608–616. Authors of [19–21] report adverse effects of β-blockers on the rat model of myocardial infarction and chronic left ventricular dysfunction.
22.
SabbahHNShimoyamaHKonoTGuptaRCSharovVGScicliGEffects of long-term monotherapy with enalapril, metoprolol, and digoxin on the progression of left ventricular dysfunction and dilation in dogs with reduced ejection fraction. Circulation1994; 89: 2852–2859.
23.
WarnerALBellahKLRayaTERoeskeWRGoldmanS. Effects of β adrenergic blockade on papillary muscle function and the β-adrenergic receptor system in noninfarcted myocardium in compensated ischemic left ventricular dysfunction. Circulation1992; 86:1584–1595. Authors of this article suggest that contractility of non-infarcted myocardium is preserved in this model of chronic left ventricular dysfunction after myocardial infarction.
24.
HuKGaudronPErtlG. Chronic effects of betablocker treatment on hemodynamics and left ventricular remodeling in rats with experimental myocardial infarction. Importance of timing of treatment and infarct size. J Am Coll Cardiol1998; 31: 692–700. This article clarifies the controversy around experimental studies of animals and clinical results by providing proof that effects of administration of β-blockers after myocardial infarction depend on size of infarct and timing of treatment.
25.
NeubauerSKraheTSchindlerRHornMHillenbrandHEntzerothCH31P-magnetic resonance spectroscopy in dilated cardiomyopathy and coronary artery disease – altered cardiac high energy phosphate metabolism in heart failure. Circulation1992; 86: 1810–1818.
26.
NeubauerSHornMCramerMHarreKNewellJBPetersWMyocardial phosphocreatine-to-ATP ratio is a predictor of mortality in patients with dilated cardiomyopathy. Circulation1997; 96: 2190–2196.
27.
KatzAM. The myocardium in congestive heart failure. Am J Cardiol1989; 63: 12A–16A.
28.
NeubauerSHornMNaumannATianRHuKLaserMImpairment of energy metabolism in intact residual myocardium of rat hearts with chronic myocardial infarction. J Clin Invest1995; 95: 1092–1100.
29.
MichelJBLattionALSalzmannJLDe Lourdes CerolMPhilippeMCamilleriJPHormonal and cardiac effects of converting enzyme inhibition in rat myocardial infarction. Circ Res1988; 62: 641–650.
30.
LaserANeubauerSTianRHuKGaudronPIngwallJSLong-term beta-blocker treatment prevents chronic creatine kinase and lactate dehydrogenase system changes in rat hearts after myocardial infarction. J Am Coll Cardiol1996; 27: 487–493. Authors of this article suggest a mechanism of preservation of function of surviving myocardium by β-blockers after myocardial infarction. The shift of cardiac proteins (including myosin) and, in this particular study, of high-energy-metabolization enzymes towards an embryonic pattern is prevented by administration of β-blockers and contractility can thereby be preserved.
31.
SharpeNMurphyJSmithHHannanS. Treatment of patients with symptomless left ventricular dysfunction after myocardial infarction. Lancet1988; I: 255–259.
32.
PfefferJMPfefferMABraunwaldE. Influence of chronic captopril therapy on the infarcted left ventricle of the rat. Circ Res1985; 57: 84–95.
33.
St John SuttonMPfefferMAPlappertTRouleauJLMoyéLADagenaisGRQuantitative two-dimensional echocardiographic measurements are major predictors of adverse cardiovascular events after acute myocardial infarction. The protective effects of captopril. Circulation1994; 89: 68–75.
34.
EichhornEJBedottoJBMalloyCRHatfieldBADeitchmanDBrownMEffect of β-adrenergic blockade on myocardial function and energetics in congestive heart failure. Improvements in hemodynamic, contractile, and diastolic performance with bucindolol. Circulation1990; 82: 473–483.
35.
See annotation [7].
36.
WoodleySLGilbertEMAndersonJLO'ConnellJBDeitchmanDYanowitzFGβ-blockade with bucindolol in heart failure caused by ischemic versus idiopathic dilated cardiomyopathy. Circulation1991; 84: 2426–2441.
37.
See annotation [7].
38.
Australia–New Zealand Heart Failure Research Collaborative Group. Effects of carvedilol, a vasodilator–β-blocker, in patients with congestive heart failure due to ischemic heart disease. Circulation1995; 92: 212–218.
39.
See annotation [7].
40.
DoughtyRNWhalleyGAGambleGMacMahonSSharpeN, on behalf of the Australian–New Zealand Heart Failure Research Collaborative Group. Left ventricular remodeling with carvedilol in patients with congestive heart failure due to ischemic heart disease. J Am Coll Cardiol1997;29: 1060–1066.