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Abstract

Objectives

To evaluate the association of general and abdominal obesity with high blood pressure in young children.

Methods

A longitudinal study including 1796 participants from the Madrid region (Spain) with baseline at age 4 years and a follow-up 2 years later. Blood pressure, body mass index and waist circumference were measured during a physical examination. We evaluated the association between obesity at baseline and weight changes between the ages of 4 and 6 years and high blood pressure. Data were analysed using linear and logistic regressions adjusted for covariates.

Results

Obese 4 year olds (general or abdominal obesity) experienced an average 4–5 mmHg increase in systolic blood pressure and a 2.5–3 mmHg increase in diastolic blood pressure by the age of 6 years. Compared to children maintaining a non-excess weight (based on body mass index) during follow-up incident and persistent cases of excess weight (overweight or obesity) had an odds ratio (OR) for high blood pressure of 2.49 (95% confidence interval (CI) 1.50–4.13) and OR 2.54 (95% CI 1.27–5.07), respectively. Regarding abdominal obesity we estimated OR 2.81 (95% CI 0.98–8.02) for incident cases and OR 3.42 (95% CI 1.38–8.49) for persistent cases. Similar estimates for the waist–height ratio were observed. Individuals who experienced remission to non-excess weight did not have an increased risk of high blood pressure.

Conclusions

We observed an increased risk for high blood pressure among 4-year-olds who presented with persistent or incident cases of excess weight (body mass index) or abdominal obesity after 2 years of follow-up. Children with excess weight or obesity at baseline who remitted to non-excess weight did not exhibit an increased risk of high blood pressure.

Keywords

Childhood obesity abdominal obesity arterial hypertension

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References

De-Onis

Blössner

. Prevalence and trends of overweight among preschool children in developing countries. Am J Clin Nutr 2000; 72: 1032–1039.

Ahrens

Pigeot

Pohlabeln

et al.

Prevalence of overweight and obesity in European children below the age of 10. Int J Obes (Lond) 2014; 38(Suppl. 2): S99–S107.

Friedemann

Heneghan

Mahtani

et al.

Cardiovascular disease risk in healthy children and its association with body mass index: systematic review and meta-analysis. BMJ 2012; 345: e4759–e4759.

Chen

Wang

. Tracking of blood pressure from childhood to adulthood: a systematic review and meta-regression analysis. Circulation 2008; 117: 3171–3180.

Lawlor

Benfield

Logue

et al.

Association between general and central adiposity in childhood, and change in these, with cardiovascular risk factors in adolescence: prospective cohort study. BMJ 2010; 341: c6224–c6224.

Huang

R-C

Burrows

Mori

et al.

Lifecourse adiposity and blood pressure between birth and 17 years old. Am J Hypertens 2015; 28: 1056–1063.

Mamun

Lawlor

O’Callaghan

et al.

Effect of body mass index changes between ages 5 and 14 on blood pressure at age 14: findings from a birth cohort study. Hypertension 2005; 45: 1083–1087.

Berentzen

van Rossem

Gehring

et al.

Overweight patterns throughout childhood and cardiometabolic markers in early adolescence. Int J Obes (Lond) 2016; 40: 58–64.

Bekkers

MBM

Brunekreef

Koppelman

et al.

BMI and waist circumference; cross-sectional and prospective associations with blood pressure and cholesterol in 12-year-olds. PLoS One 2012; 7: e51801–e51801.

10.

Howe

Chaturvedi

Lawlor

et al.

Rapid increases in infant adiposity and overweight/obesity in childhood are associated with higher central and brachial blood pressure in early adulthood. J Hypertens 2014; 32: 1789–1796.

11.

Juonala

Magnussen

Berenson

et al.

Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med 2011; 365: 1876–1885.

12.

Bloetzer

Bovet

Suris

J-C

et al.

Screening for cardiovascular disease risk factors beginning in childhood. Public Health Rev 2015; 36: 9–9.

13.

Schröder

Ribas

Koebnick

et al.

Prevalence of abdominal obesity in Spanish children and adolescents. Do we need waist circumference measurements in pediatric practice?

PLoS One 2014; 9: e87549–e87549.

14.

Dobashi

. Evaluation of obesity in school-age children. J Atheroscler Thromb 2016; 23: 32–38.

15.

Ortiz-Marrón

Cuadrado-Gamarra

Esteban-Vasallo

et al.

Estudio Longitudinal de Obesidad Infantil (ELOIN): diseño, participación y características de la muestra. Rev Española de Cardiol 2016; 69: 521–523.

16.

Onis

M de

Adelheid

W Onyango

Borghi

et al.

Development of a WHO growth reference for school-aged children and adolescents. Bull WHO 2007; 85(Suppl. 9): 660–667.

17.

Fernández

Redden

Pietrobelli

et al.

Waist circumference percentiles in nationally representative samples of African-American, European-American, and Mexican-American children and adolescents. J Pediatr 2004; 145: 439–444.

18.

Alberti

Zimmet

Kaufman

et al.

The IDF consensus definition of the metabolic syndrome in children and adolescents. Pediatr Diabetes 2007; 8: 299–306.

19.

Nambiar

Hughes

Davies

. Developing waist-to-height ratio cut-offs to define overweight and obesity in children and adolescents. Public Health Nutr 2010; 13: 1566–1574.

20.

National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004; 114(2 Suppl. 4th Report): 555–576.

21.

Lurbea

Agabiti-Rosei

Cruickshank

et al.

2016 European Society of Hypertension Guidelines for the management of high blood pressure in children and adolescents. J Hypertens 2016; 34: 1887–1920.

22.

Boyce

Torsheim

Currie

et al.

The family affluence scale as a measure of national wealth: validation of an adolescent self-report measure. Soc Indic Res 2006; 78(Suppl. 3): 473–487.

23.

Marcus

Foster

El Ghormli

et al.

Shifts in BMI category and associated cardiometabolic risk: prospective results from HEALTHY study. Pediatrics 2012; 129: e983–e991.

24.

Maximova

O’Loughlin

Paradis

et al.

Changes in anthropometric characteristics and blood pressure during adolescence. Epidemiology 2010; 21: 324–331.

25.

Munthali

Kagura

Lombard

et al.

Childhood adiposity trajectories are associated with late adolescent blood pressure: birth to twenty cohort. BMC Public Health 2016; 16: 665–665.

26.

Jones

Charakida

Falaschetti

et al.

Adipose and height growth through childhood and blood pressure status in a large prospective cohort study. Hypertension 2012; 59: 919–925.

27.

Eckert

DiMeglio

et al.

Intensified effect of adiposity on blood pressure in overweight and obese children. Hypertension 2011; 58: 818–824.

28.

Howe

Galobardes

Sattar

et al.

Are there socioeconomic inequalities in cardiovascular risk factors in childhood and are they mediated by adiposity? Findings from a prospective cohort study. Int J Obes (Lond) 2010; 34: 1149–1159.

29.

Browning

Hsieh

Ashwell

. A systematic review of waist-to-height ratio as a screening tool for the prediction of cardiovascular disease and diabetes: 0·5 could be a suitable global boundary value. Nutr Res 2010; 23: 247–269.

30.

Simmonds

Llewellyn

Owen

et al.

Simple tests for the diagnosis of childhood obesity: a systematic review and meta-analysis. Obes Rev 2016; 17: 1301–1315.

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Association between general and central adiposity and development of hypertension in early childhood

Abstract

Objectives

Methods

Results

Conclusions

Keywords

Get full access to this article

References

Supplementary Material