Abstract
In clinical practice, perfusional MR has been successfully proposed in the study of pathophysiology of stroke, seeming able to help in distinguishing ischaemic necrosis from penumbra. In tumor evolution, the main application concerns the attempt of grading and follow up the lesions: areas in initial malignant transformation with microvascular proliferation in absence of endotelial (and BBB alterations), can be recognized. For the above, the tecnique is recommended in guiding cerebral biopsies toward correct triggers. For similar reason the differential evaluation of post-treatment necrosis from recurrency can take advantage from perfusional MR.
Moreover, it could be predictable the possibility of employement in following tumors treated with genic therapy, in a simple and atraumatic way. In the field of epilepsy good correlations with PET and SPET has stayed on evaluating temporal perfusion in case of parahippocampal sclerosis. Promising perspectives are also present in metabolic-degenerative field. The correlation with PET studies in case of Alzheimer disesease, in fact, reaches 80%, with clear documentation of temporal and parietal cortical hypoperfusion. Our experience, performed with a 0.5 T operating magnet on more than 80 patients, confirms the results already reported in literature.
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