La Spettroscopia Protonica a Risonanza Magnetica (MRS) è una tecnica non invasiva che permette di misurare in vivo i livelli di sostanze chimiche differenti fornendo informazioni chimico-metaboliche sulla struttura tissutale. La recente diffusione di tale tecnica e la disponibilità ed il perfezionamento di programmi computerizzati di facile impiego ne rendono possibile l'applicazione su ampia scala permettendo l'attuazione di sofisticati studi di ricerca.
L'impiego nella pratica clinica è tuttavia ancora piuttosto scarso sia per limiti tecnici legati alla difficoltà di ottenere risoluzione spaziale e rapporto segnale-rumore ottimali, sia per i lunghi tempi di esame che la maggior parte dei programmi in uso impongono al paziente.
Nel nostro studio abbiamo utilizzato il programma PROBE (Single-voxel Proton Brain Exam), con cui è possibile acquisire spettri da singoli volumi di interesse in modo automatico, cosicché il tempo complessivo dell'esame di MRS è di circa 9 minuti, con massima tollerabilità anche da parte di piccoli pazienti sottoposti a studio in narcosi.
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