I mezzi di contrasto (mdc) consentono un miglioramento delle possibilità diagnostiche della Risonanza Magnetica (RM) mediante una modificazione differenziale dei parametri tissutali di rilassamento. Tra i mdc paramagnetici accanto al Gadolinio-DTPA, che ha dimostrato una buona efficacia ed una tossicità trascurabile, altre molecole si candidano ad un esame clinico più approfondito. Ottime prospettive sono offerte dai mdc superparamagnetici nello studio RM dell'addome. Le moderne biotecnologie possono consentire di produrre mdc dotati di tropismo di organo, tessuto o lesione.
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