Chikungunya virus can be transmitted perinatally leading to serious neurological sequelae. We report the longitudinal evolution of the brain magnetic resonance imaging aspects of three cases of mother-to-child Chikungunya virus transmission. The first magnetic resonance imaging scan presented brain cavitations, with or without corpus callosum diffusion restriction. Follow-up scans showed reduction in the volume of cavitations, with resolution of the restricted diffusion. However, one patient presented with a normal brain magnetic resonance image, despite the delay in neurocognitive development.
MorrisonCRPlanteKSHeiseMT.Chikungunya virus: current perspectives on a reemerging virus. Microbiol Spectr2016;
4: 1–14.
2.
Villamil-GómezWAlba-SilveraLMenco-RamosA, et al.
Congenital Chikungunya virus infection in Sincelejo, Colombia: a case series. J Trop Pediatr2015;
61: 386–392.
3.
FritelXRollotOGerardinP, et al.
Chikungunya virus infection during pregnancy, Reunion, France, 2006. Emerg Infect Dis2010;
16: 418–425.
4.
Contopoulos-IoannidisDNewman-LindsaySChowC, et al.
Mother-to-child transmission of Chikungunya virus: a systematic review and meta-analysis. PLoS Negl Trop Dis2018;
12: e0006510.
5.
CorrêaDGFreddiTALWernerH, et al.
Brain MR imaging of patients with perinatal Chikungunya virus infection. AJNR Am J Neuroradiol2020;
41: 174–177.
6.
GérardinPSampérizSRamfulD, et al.
Neurocognitive outcome of children exposed to perinatal mother-to-child Chikungunya virus infection: the CHIMERE cohort study on Reunion Island. PLoS Negl Trop Dis2014;
8: e2996.
7.
LaoprasopwattanaKSuntharasajTPetmaneeP, et al.
Chikungunya and dengue virus infections during pregnancy: seroprevalence, seroincidence and maternalefetal transmission, southern Thailand, 2009–2010. Epidemiol Infect2016;
144: 381–388.
8.
GérardinPBarauGMichaultA, et al.
Multidisciplinary prospective study of mother-to-child Chikungunya virus infections on the island of La Réunion. PLoS Med2008;
5: e60.
9.
RamfulDCarbonnierMPasquetM, et al.
Mother-to-child transmission of Chikungunya virus infection. Pediatr Infect Dis J2007;
26: 811–815.
10.
SarmaAHanzlikEKrishnasarmaR, et al.
Human parechovirus meningoencephalitis: neuroimaging in the era of polymerase chain reaction-based testing. AJNR Am J Neuroradiol2019;
40: 1418–1421.
CoudercTChrétienFSchilteC, et al.
A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog2008;
4: e29.
13.
RadaelliGLahorgue NunesMBernardi SoderR, et al.
Review of neuroimaging findings in congenital Zika virus syndrome and its relation to the time of infection. Neuroradiol J2020;
33: 152–157.
SanchezTRDatlowMDNideckerAE.Diffuse periventricular calcification and brain atrophy: a case of neonatal central nervous system cytomegalovirus infection. Neuroradiol J2016;
29: 314–316.
