Intercontinental validation of brain volume measurements using MSmetrix

Abstract

Background

Brain volume assessment has become an important outcome within research and treatment of multiple sclerosis (MS). MSmetrix (Icometrix) has been developed specifically for patients with MS. The original healthy, ‘normal’ population used for determination of the acceptable brain volume data consisted mainly of Europeans.

Methods

In the present study, results from 295 completely normal magnetic resonance imaging scans from Brazilian subjects were plotted against the original results in MSmetrix.

Results

With regard to whole brain volume, only 2% of the healthy adult subjects from Brazil were below the 5th percentile of the graph, and for grey matter volume, only 3% of the subjects were below the 5th percentile of MSmetrix standards.

Conclusion

MSmetrix may be used across different populations.

Keywords

Multiple sclerosis brain volume brain atrophy magnetic resonance image

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