Restricted accessCase reportFirst published online 2018-4
Magnetic resonance imaging in central nervous system vasculitis in a patient affected by crioglobulin-negative hepatitis C virus infection: A likely correlation
A 56-year-old man with behavioural disorders and facial-brachio-crural right hemiparesis presented with a brain lesion studied with computed tomography, magnetic resonance imaging and brain biopsy, leading to the diagnosis of cerebral vasculitis. Hepatitis C virus (HCV) infection in a phase of activity, without cryoglobulins, was also detected. Brain biopsy, laboratory analysis and response to a specific therapy supported the diagnosis of central nervous system vasculitis that was HCV related.
Carvalho-FilhoRJNarciso-SchiavonJLTolentinoLHet al.Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C. World J Gastroenterol2012; 18: 188–191.
3.
MonacoSMariottoSFerrariSet al.Hepatitis C virus-associated neurocognitive and neuropsychiatric disorders: advances in 2015. World J Gastroenterol2015; 21: 11974–11983.
4.
MorraE. Cryoglobulinemia. Hematology Am Soc Hematol Educ Program2005; 1: 368–372.
5.
Castro CaldasAGeraldesRnetoLet al.Central nervous system vasculitis associated with hepatitis C virus infection: a brain MRI-supported diagnosis. J Neurol Sci2014; 336: 152–154.
6.
MathewSFaheemMIbrahimSMet al.Hepatitis C virus and neurological damage. World J Hepatol2016; 8: 545–556.
7.
FletcherNFMcKeatingJA. Hepatitis C virus and the brain. J Viral Hepat2012; 19: 301–306.
8.
NemniRSanvitoLQuattriniAet al.Peripheral neuropathy in hepatitis C virus infection with and without cryoglobulinemia. J Neurol Neurosurg Psychiatry2003; 74: 1267–1271.
9.
FerriCRamos-CasalsMZignegoALet al.International diagnostic guidelines for patients with HCV-related extrahepatic manifestations. A multidisciplinary expert statement. Autoimmun Rev2016; 15: 1145–1160.