Malignant melanoma is the third most common tumour to cause cerebral metastases, following breast and lung cancer. Central nervous system metastases occur in 10–40% of patients with melanoma. Intracranial metastasis from a primary malignant melanoma of the anterior mediastinum is uncommon. We report a case of solitary intracranial metastatic melanoma arising from a primary mediastinal tumour. We then discuss the clinico-radiological features and treatment options.
Goulart CR, Mattei TA and Ramina R. Cerebral melanoma metastases: a critical review on diagnostic methods and therapeutic options. ISRN Surg 2011; 2011.
2.
FeldmanLKricunME. Malignant melanoma presenting as a mediastinal mass. JAMA1979; 241: 396–397.
3.
LauCLBentleyRCGockermanJP. Malignant melanoma presenting as a mediastinal mass. Ann Thorac Surg1999; 67: 851–852.
4.
ParkSYKimMYChaeEJ. Primary malignant melanoma of the mediastinum: radiologic and pathologic correlation in two case. Korean J Radiol2012; 13: 823–826.
5.
PandyaBRamrajeSDaradeA. Primary malignant melanoma of the mediastinum. J Assoc Physicians India2004; 52: 924–925.
6.
TakaoHShimizuSDoiI. Primary malignant melanoma of the anterior mediastinum: CT and MR findings. Clin Imaging2008; 32: 58–60.
7.
KalraAKalraAPalaniswamyC. Primary malignant melanoma presenting as superior mediastinal mass. Int J Surg Case Rep2011; 2: 239–240.
8.
VlodavskyEBen-IzhakOBestLA. Primary malignant melanoma of the anterior mediastinum in a child. Am J Surg Pathol2000; 24: 747–749.
9.
KaruppiahSVBuchanKG. Primary malignant melanoma: a rare cause of mediastinal mass. Jpn J Thorac Cardiovasc Surg2006; 54: 396–398.
10.
ShishidoMNagaoNMiyamotoK. [Mediastinal amelanotic melanoma presenting as superior vena cava syndrome]. Nihon Kyobu Shikkan Gakkai Zasshi1997; 35: 240–244.
11.
KimHRLeeJSKimYT. Primary malignant melanoma presenting as an anterior mediastinal mass. Korean J Thorac Cardiovasc Surg2002; 35: 697–700.
12.
GavianiPMullinsMEBragaTA. Improved detection of metastatic melanoma by T2*-weighted imaging. AJNR Am J Neuroradiol2006; 27: 605–608.
13.
Shapiro DG and Samlowski WE. Management of melanoma brain metastases in the era of targeted therapy. J Skin Cancer 2011; 2011.
14.
LoewenthalBShiauMCGarciaR. Metastatic melanoma: an unusual diagnosis for a large anterior mediastinal mass. Radiographics2004; 24: 1714–1718.
15.
Lee leMFeunLTanY. A case of intracranial hemorrhage caused by combined dabrafenib and trametinib therapy for metastatic melanoma. Am J Case Rep2014; 15: 441–443.
