The aim of the present study was to assess the presence of changes in diffusivity in the brains of patients with tuberous sclerosis (TS) in areas free from signal alterations on conventional MR sequences. Ten patients and controls were evaluated. ROI were placed on ADC maps in the white matter (frontal, parietal and centrum semiovale) excluding areas with signal alterations on FLAIR images. ADC values of supratentorial white matter turned out to be higher than controls (P < .0001). Our data indicate that TS is more widely diffused than expected in the brains of affected patients.
SampsonJRSchahillSJStephensonJBPMannLConnorJM. Genetic aspects of tuberous sclerosis in the west of Scotland. J Med Genet1989; 26: 28–31.
2.
CrinoPBHenskeEP. New developments in the neurobiology of the tuberous sclerosis complex. Neurology1999; 53: 1384–1390.
3.
FranzDN. Diagnosis and management of tuberous sclerosis complex. Semin Pediatr Neurol1998; 5: 253–268.
4.
GutmannDH. Parallels between tuberous sclerosis complex and neurofibromatosis I: Common threads in the same tapestry. Semin Pediatr Neurol1998; 276–286.
5.
ShephardCWHouserOWGomezMR. MR findings in tuberous sclerosis complex and correlation with seizure development and mental impairment. AJNR Am J Neuroradiol1995; 16: 149–155.
6.
JambaqueICusmaiRCuratoloP. Neuropsychological aspects of tuberous sclerosis in relation to epilepsy and MRI findings. Dev Med Child Neurol1991; 33: 698–705.
7.
RoachESWilliamsDPLasterDW. Magnetic resonance imaging in tuberous sclerosis. Arch Neurol1987; 44: 301–303.
8.
GoodmanMLammSEngelA: Cortical tuber count: A biological marker indicating neurologic severity of tuberous sclerosis complex. J Child Neurol1997; 12: 85–90.
9.
RydbergJNHammondCAGrimmRC: Initial clinical experience in MR imaging of the brain with fast fluid attenuated inversion-recovery pulse sequence. Radiology1994; 193: 173–180.
10.
GrossmanRIGomoriJMRamerKNLexaFJSchnallMD. Magnetization transfer: Theory and clinical applications in neuroradiology. Radiographics1994; 14: 279–290.
11.
MaedaMTartaroAMatsudaTIshiiY. Cortical and subcortical tubers in tuberous sclerosis and FLAIR sequence. JCAT1995; 19: 660–667.
12.
GirardNZimmermanRASchnurREHaselgroveJChristensenK. Magnetization transfer in the investigation of patients with tuberous sclerosis. Neuroradiology1997 Jul; 39 (7): 523–8.
