Subtypes of sinusitis have different symptoms and prognoses due to different pathogens. Odontogenic maxillary sinusitis (OMS) mainly occurs unilaterally and is different from chronic rhinosinusitis (CRS) usually occurring bilaterally in terms of clinical characteristics. However, comprehensive microbiological comparisons between OMS and CRS have never been systematically conducted and most comparisons are methodologically biased. This study aims to provide a comprehensive analysis of the microbiology associated with OMS and CRS through a meta-analysis approach in order to provide evidence for differential diagnosis of OMS and CRS from a microbiological perspective.
Methods
The databases PubMed and CNKI were searched from their inception to July 2023. A random-effects model was employed to derive the pooled prevalence estimates of the identified bacterial species or genera.
Results
The 17 represented studies included 6 concerning OMS, 12 concerning CRS, and 4 concerning normal sinus, yielding 191, 610, and 92 samples, respectively. Though not statistically significant, the prevalence of Peptostreptococcus and Prevotella was generally higher in OMS compared to CRS. Notably, Fusobacterium was identified as the only genus with a significantly higher prevalence in OMS compared to CRS.
Conclusion
Fusobacterium was significantly more prevalent in OMS compared with CRS, while Staphylococcus aureus was more prevalent in CRS than in OMS. Such differences in bacterial profile may partly explain the distinct pathology observed and contribute to the development of novel strategies for diagnosis and therapeutic interventions in OMS.
VitaliFCSantosPSMassignanC, et al.Global prevalence of maxillary sinusitis of odontogenic origin and associated factors: a systematic review and meta-analysis. J Endod. 2023;49:369-381. doi: https://doi.org/10.1016/j.joen.2023.01.010
2.
ZirkMDreiseidlerTPohlM, et al.Odontogenic sinusitis maxillaris: a retrospective study of 121 cases with surgical intervention. J Craniomaxillofac Surg. 2017;45:520-525. doi: https://doi.org/10.1016/j.jcms.2017.01.023
3.
LinJWangCWangX, et al.Expert consensus on odontogenic maxillary sinusitis multi-disciplinary treatment. Int J Oral Sci. 2024;16:11. doi: https://doi.org/10.1038/s41368-024-00278-z
4.
KuharHNTajudeenBAMahdaviniaM, et al.Relative abundance of nasal microbiota in chronic rhinosinusitis by structured histopathology. Int Forum Allergy Rhinol. 2018;8:1430-1437. doi: https://doi.org/10.1002/alr.22192
BorensteinMHedgesLVHigginsJP, et al.A basic introduction to fixed-effect and random-effects models for meta-analysis. Res Synth Methods. 2010;1:97-111. doi: https://doi.org/10.1002/jrsm.12
KondrashevPALodochkinaOEOpryshkoON. Microbiological spectrum of causative agents of rhinogenic and odontogenic chronic sinusitis and mucociliary activity of mucosal epithelium in the nasal cavity. Vestn Otorinolaringol. 2010;(4):45-47.
9.
PuglisiSPriviteraSMaiolinoL, et al.Bacteriological findings and antimicrobial resistance in odontogenic and non-odontogenic chronic maxillary sinusitis. J Med Microbiol. 2011;60:1353-1359. doi: https://doi.org/10.1099/jmm.0.031476-0
10.
Yassin-KassabABhargavaPTibbettsRJ, et al.Comparison of bacterial maxillary sinus cultures between odontogenic sinusitis and chronic rhinosinusitis. Int Forum Allergy Rhinol. 2021;11:40-47. doi: https://doi.org/10.1002/alr.22627
11.
TajimaSNakamuraMItoS, et al.Presence of anaerobic bacteria and symptoms supports diagnosis of odontogenic sinusitis. Am J Otolaryngol. 2022;43:103544. doi: https://doi.org/10.1016/j.amjoto.2022.103544
12.
CraigJRDaiXBellemoreS, et al.Inflammatory endotype of odontogenic sinusitis. Int Forum Allergy Rhinol. 2023;13:998-1006. doi: https://doi.org/10.1002/alr.23099
13.
ItoKItoYMizutaK, et al.Bacteriology of chronic otitis media, chronic sinusitis, and paranasal mucopyocele in Japan. Clin Infect Dis. 1995;20(Suppl 2):S214-S219. doi: https://doi.org/10.1093/clinids/20.supplement_2.s214
HartogBDegenerJEVan BenthemPP, et al.Microbiology of chronic maxillary sinusitis in adults: isolated aerobic and anaerobic bacteria and their susceptibility to twenty antibiotics. Acta Otolaryngol. 1995;115:672-677. doi: https://doi.org/10.3109/00016489509139385
16.
KremerBJacobsJASoudijnER, et al.Clinical value of bacteriological examinations of nasal and paranasal mucosa in patients with chronic sinusitis. Eur Arch Otorhinolaryngol. 2001;258:220-225. doi: https://doi.org/10.1007/s004050100342
17.
BrookI. Discrepancies in the recovery of bacteria from multiple sinuses in acute and chronic sinusitis. J Med Microbiol. 2004;53:879-885. doi: https://doi.org/10.1099/jmm.0.45655-0
18.
KostamoKRichardsonMVirolainen-JulkunenA, et al.Microbiology of chronic hyperplastic sinusitis. Rhinology. 2004;42:213-218.
19.
NigroJFNigroCEMaroneSA, et al.Microbiology of the maxillary and ethmoid sinuses in patients with chronic rhinosinusitis submitted to functional endoscopic sinus surgery. Braz J Otorhinolaryngol. 2006;72:217-222. doi: https://doi.org/10.1016/s1808-8694(15)30058-6
20.
PosawetzWStammbergerHHorinaJ, et al.Anaerobic bacteria in normal and in chronically inflamed paranasal Sinus Mucosa. Am J Rhinol.1991;5:43-46. doi: https://doi.org/10.2500/105065891782112879
BrookI. Aerobic and anaerobic bacterial flora of normal maxillary sinuses. Laryngoscope. 1981;91:372-376.
23.
WeiHZLiYCWangXD, et al.The microbiology of chronic rhinosinusitis with and without nasal polyps. Eur Arch Otorhinolaryngol. 2018;275:1439-1447. doi: https://doi.org/10.1007/s00405-018-4931-6
24.
WuJZhengMZhaoY, et al.Bacterial diversity and community characteristics of the sinus and dental regions in adults with odontogenic sinusitis. BMC Microbiol. 2023;23:201. doi: https://doi.org/10.1186/s12866-023-02917-7
25.
LuYTWangSHLiouML, et al.Microbiota dysbiosis in odontogenic rhinosinusitis and its association with anaerobic bacteria. Sci Rep. 2022;12:21023. doi: https://doi.org/10.1038/s41598-022-24921-z
26.
WlodarskaMLuoCKoldeR, et al.Indoleacrylic acid produced by commensal Peptostreptococcus species suppresses inflammation. Cell Host Microbe. 2017;22:25-37. doi: https://doi.org/10.1016/j.chom.2017.06.007
27.
BradshawDJMarshPDWatsonGK, et al.Role of Fusobacterium nucleatum and coaggregation in anaerobe survival in planktonic and biofilm oral microbial communities during aeration. Infect Immun. 1998;66:4729-4732. doi: https://doi.org/10.1128/IAI.66.10.4729-4732.1998
MatsuiAJinJOJohnstonCD, et al.Pathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils. Infect Immun. 2014;82:4068-4079. doi: https://doi.org/10.1128/IAI.02256-14
31.
GroegerSDomanEChakrabortyT, et al.Effects of Porphyromonas gingivalis infection on human gingival epithelial barrier function in vitro. Eur J Oral Sci. 2010;118:582-589. doi: https://doi.org/10.1111/j.1600-0722.2010.00782.x
32.
SatoKChitoseSISatoK, et al.Histopathology of maxillary sinus mucosa with odontogenic maxillary sinusitis. Laryngoscope Investig Otolaryngol. 2020;5:205-209. doi: https://doi.org/10.1002/lio2.376
33.
VickeryTWRamakrishnanVRSuhJD. The role of Staphylococcus aureus in patients with chronic sinusitis and nasal polyposis. Curr Allergy Asthma Rep. 2019;19:21. doi: https://doi.org/10.1007/s11882-019-0853-7
34.
HaiderAAMarinoMJYaoWC, et al.The potential of high-throughput DNA sequencing of the paranasal sinus microbiome in diagnosing odontogenic sinusitis. Otolaryngol Head Neck Surg. 2019;161:1043-1047. doi: https://doi.org/10.1177/0194599819866692
35.
KasparUKriegeskorteASchubertT, et al.The culturome of the human nose habitats reveals individual bacterial fingerprint patterns. Environ Microbiol. 2016;18:2130-2142. doi: https://doi.org/10.1111/1462-2920.12891
36.
FeazelLMRobertsonCERamakrishnanVR, et al.Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012;122:467-472. doi: https://doi.org/10.1002/lary.22398
37.
SzaleniecJBezshapkinVKrawczykA, et al.Determinants of the microbiome spatial variability in chronic rhinosinusitis. Rhinology. 2024;62:119-126. doi: https://doi.org/10.4193/Rhin22.423
