Genetic science has made remarkable advances in the 21st century. As genetic and genomic sciences continue to expand, school nurses will become thoroughly immersed in data, information, and technology. As new diseases, treatments, and therapies are discovered, school nurses will need to implement and assess best practices for the complex and medically fragile student population. This article will discuss the top 10 recent discoveries in genomic science and how school nurses can use this information in clinical practice.
AdliM. (2018). The CRISPR tool kit for genome editing and beyond. Nature Communications, 9, 1911. doi:10.1038/s41467-018-04252-2
2.
AhmedH.HowtonT. C.SunY.WeinbergerN.BelkhadirY.MukhtarM. S. (2018). Network biology discovers pathogen contact points in host protein–protein interactomes. Nature Communications, 9, 2312. doi:10.1038/s41467-018-04632-8
3.
AndreaniJ.VerneauJ.RaoultD.LevasseurA.La ScolaB. (2018). Deciphering viral presences: Two novel partial giant viruses detected in marine metagenome and in a mine drainage metagenome. Virology Journal, 15, 66. doi:10.1186/s12985-018-0976-9
4.
AntwerpenM. H.GeorgiE.ZoellerL.WoelfelR.StoeckerK.ScheidP. (2015). Whole-genome sequencing of a pandoravirus isolated from keratitis-inducing acanthamoeba. Genome Announcements, 3(2). doi:10.1128/genomeA.00136-15
5.
BadatM.DaviesJ. (2017). Gene therapy in a patient with sickle cell disease. New England Journal of Medicine, 376, 2093-2094. doi:10.1056/NEJMc1704009
6.
BungerJ. (2006). The role of the nurse in genetic counseling. Nebraska Nursing News, 23(2), 8-9.
7.
CalzoneK.CashionA.FeethamS.JenkinsJ.ProwsC.WilliamsJ.WungS. F. (2010). Nurses transforming healthcare using genetics and genomics. Nurse Outlook, 58(1), 26-35. doi:10.1016/j.outlook.2009.05.001
8.
DemirciS.UchidaN.TisdaleJ. F. (2018). Gene therapy for sickle cell disease: An update. Cytotherapy, 20, 899-910. doi:10.1016/j.jcyt.2018.04.003
9.
EidA.MahfouzM. M. (2016). Genome editing: The road of CRISPR/Cas9 from bench to clinic. Experimental & Molecular Medicine, 48(10), e265. doi:10.1038/emm.2016.111
10.
FeeroW. G.GuttmacherA. E.CollinsF. S. (2010). Genomic medicine: An updated primer. New England Journal of Medicine, 362, 2001-2011.
11.
FeinbergA. P. (2018). The key role of epigenetics in human disease prevention and mitigation. New England Journal of Medicine, 378, 1323-1334. doi:10.1056/NEJMra1402513
12.
GahlW. A.MulvihillJ. J.ToroC.MarkelloT. C.WiseA. L.RamoniR. B.. . . TifftC. J. (2016). The NIH Undiagnosed Diseases Program and Network: Applications to modern medicine. Molecular Genetics and Metabolism, 117, 393-400. doi:10.1016/j.ymgme.2016.01.007
13.
GreenE. D.WatsonJ. D.CollinsF. S. (2015). Human Genome Project: Twenty-five years of big biology. Nature, 526(7571), 29-31. doi:10.1038/526029a
14.
GuttmacherA. E.CollinsF. S. (2002). Genomic medicine: A primer. New England Journal of Medicine, 347, 1512-1520. doi:10.1056/NEJMra012240
15.
KirkM. (2009). Understanding the role of genetics and genomics in health 2: Implications for practice. Nursing Times, 105(46), 19-23.
16.
LeboulchP.CavazzanaM. (2017). Gene therapy in a patient with sickle cell disease. New England Journal of Medicine, 376, 2094. doi:10.1056/NEJMc1704009
17.
LegendreM.FabreE.PoirotO.JeudyS.LartigueA.AlempicJ.-M.. . . ClaverieJ.-M. (2018). Diversity and evolution of the emerging Pandoraviridae family. Nature Communications, 9, 2285.
18.
LiuS.WangQ.YuX.LiY.GuoY.LiuZ.. . . ChenS. (2018). HIV-1 inhibition in cells with CXCR4 mutant genome created by CRISPR-Cas9 and piggyBac recombinant technologies. Sci Rep, 8(1), 8573. doi:10.1038/s41598-018-26894-4
19.
MoraesF.GoesA. (2016). A decade of human genome project conclusion: Scientific diffusion about our genome knowledge. Biochemistry and Molecular Biology Education, 44, 215-223. doi:10.1002/bmb.20952
20.
National Association of School Nurses. (2016). Framework for 21st century school nursing practice: National Association of School Nurses. NASN School Nurse, 31(1), 45-53. doi:10.1177/1942602X15618644
NerlichB.HellstenI. (2004). Genomics: Shifts in metaphorical landscape between 2000 and 2003. New Genetics and Society, 23, 255-268. doi:10.1080/1463677042000305039
23.
PevsnerJ. (2015). Bioinformatics and functional genomics. Chichester, England: Wiley.
24.
PiatekA. A.LenaghanS. C.Neal StewartC.Jr. (2018). Advanced editing of the nuclear and plastid genomes in plants. Plant Science, 273, 42-49. doi:10.1016/j.plantsci.2018.02.025
25.
RibeilJ. A.Hacein-Bey-AbinaS.PayenE.MagnaniA.SemeraroM.MagrinE.. . . CavazzanaM. (2017). Gene therapy in a patient with sickle cell disease. New England Journal of Medicine, 376, 848-855. doi:10.1056/NEJMoa1609677
26.
SuravajhalaP.KogelmanL. J.KadarmideenH. N. (2016). Multi-omic data integration and analysis using systems genomics approaches: Methods and applications in animal production, health and welfare. Genetics, Selection, Evolution, 48(1), 38. doi:10.1186/s12711-016-0217-x
27.
YinH.XueW.ChenS.BogoradR. L.BenedettiE.GrompeM.. . . AndersonD. G. (2014). Genome editing with Cas9 in adult mice corrects a disease mutation and phenotype. Nature Biotechnology, 32, 551-553. doi:10.1038/nbt.2884
28.
ZhenS.HuaL.LiuY. H.GaoL. C.FuJ.WanD. Y.. . . GaoX. (2015). Harnessing the clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated Cas9 system to disrupt the hepatitis B virus. Gene Therapy, 22, 404-412. doi:10.1038/gt.2015.2
