Abstract
This study used bibliometric analysis to comprehensively map the research landscape of immunomodulatory biomaterials enhancing implant osseointegration between 2005 and 2025. Publications retrieved from the Web of Science Core Collection were analyzed to identify temporal trends, contributing countries, institutions, journals, cocitation networks, and keyword evolution. A total of 419 articles were identified. The annual output and citations increased steadily, with China, the United States, and Australia as major contributors. The terms ‘3D printing’, ‘scaffolds’, and ‘macrophage polarization’ emerged as recent hotspots, reflecting a shift from mechanistic exploration to clinical translation. Compared with prior reviews focusing mainly on mechanisms, this study also analyzed the depth of international collaboration, clinical orientation of journals, and bottlenecks in translational application. The field has evolved from theoretical construction (osteoimmunomodulation theory) to technological innovation (nanoengineering, dynamic response design). Future work should integrate intelligent responsive biomaterials with multiomics validation to accelerate the transition from passive repair to active regulation in bone regeneration.
Impact Statement
The findings redirect future investigations toward dynamic, microenvironment-responsive designs validated by multiomics and large-animal models, inform clinicians about next-generation precision implants, and guide funding agencies and regulators in prioritizing standards and incentives for translating immunomodulatory biomaterials into personalized osseointegration therapies.
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