The capacity for tissue regeneration declines with age, and cellular senescence is recognized as a critical driver of aging and impaired tissue regeneration potential. Advances in stem cell research have provided new insights into tissue regeneration and stem cell therapy in aging-related diseases. However, stem cell senescence significantly limits their therapeutic efficacy, highlighting the need for effective rejuvenation strategies. Current antisenescence approaches have shown promise, but they still face limitations. This review summarizes and discusses the characteristics and consequences of mesenchymal stem cells (MSCs) senescence and evaluates existing antisenescence strategies. Additionally, recent advancements in biomaterials have demonstrated considerable potential in modulating stem cell fate and enhancing tissue regeneration outcomes. In this context, we explore biomaterial-based approaches for rejuvenating senescent MSCs, offering novel perspectives for advancing tissue regeneration therapies targeting aging-related diseases.
Impact Statement
Mesenchymal stem cells (MSCs) senescence limits the effectiveness of regenerative therapies in aging populations. This review critically evaluates current antisenescence strategies and highlights the emerging role of biomaterial-based approaches that mimic the stem cell niche to rejuvenate senescent MSCs. By integrating recent advances in biomaterials, this review offers a novel perspective on developing safer, more targeted interventions for age-related tissue degeneration. It provides timely insights for translational research and the development of next-generation therapies aimed at improving health span and regenerative capacity in the elderly.
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