4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives via Microwave-Assisted Sequential Three Component Reaction in Green Solvent

Abstract

Novel 1,4-pyranonaphthoquinone derivatives were successfully synthesized via the microwave-assisted three-component reaction of 1,4-naphthoquinone, malononitrile, and various arylaldehydes in ethanol in the presence of 4-(dimethylamino)pyridine (DMAP) as a catalyst, and subsequently evaluated in terms of their antimicrobial and antifungal activities. This synthetic procedure has the notable advantages of environmental friendliness, short reaction time, good yield, and convenient operation.

Keywords

1,4-pyranonaphthoquinone 2-amino-3-cyano-chromene 4-(dimethylamino)pyridine sequential three component reaction DMAP

Introduction

Naphthoquinone derivatives, including naphtho[2,3-b]furan,¹ naphtho[2,3-c]furan,² pyranonaphthoquinone,³ and benzoquinoline,⁴ are known redox-active compounds that are found in several families of plants, and have been isolated from fungi, algae, and bacteria. Especially, some 1,4-pyranonaphthoquinone derivatives represent a “privileged” structural motif well distributed in naturally occurring compounds such as β-lapachone (1),⁵ α-xiloidone (2),⁶ pentalongin (3),^7,8 and dehydroherbarin (4)⁹ (Figure 1). These derivatives possess a wide range of pharmacological activities, for example, anticancer,¹⁰ antitumor,¹¹ leishmanicidal,¹² antibacterial, antifungal,¹³ and cytotoxic.¹⁴

Figure 1.

Some naturally occurring 1,4-pyranonaphthoquinone derivatives and chromene structures.

On the other hand, chromenes, which are components of numerous naturally occurring products, like calanolides,^15,16 and calophyllolides,¹⁷ have been “key” scaffolds associated with a wide range of pharmacological activities including anticancer,^18,19 anti-HIV,^20,21 antitumor,²² antiproliferation,²³ antibacterial,²⁴ and antimalarial.^25,26 Moreover, a huge number of synthetic 2-amino-3-cyano-chromene derivatives possess potential biological activities, for example, compound 5 has exhibited antibacterial activity against Staphylococcus aureus, compounds 6, 7, and 8 have strong inhibitory activity against Epidermophyton floccosum, and compound 8 has exhibited activity against Aspergillus clavatus, Candida glabarata, C. dubliniensis, C. albicans, and C. tropicalis (Figure 1).²⁷

Due to the potential biological activities of 1,4-pyranonaphthoquinone derivatives, as well as 2-amino-3-cyano-chromene skeletons, the synthesis of 1,4-pyranonaphthoquinone derivatives bearing amino and cyano groups has attracted the attention of many researchers.^28-30 So far, several synthetic methods have been reported for the synthesis of derivatives of this structural type via three-component reactions of 2-hydroxy-1,4-naphthoquinone, malononitrile, and arylaldehydes. The conventional synthesis utilizes a catalyst such as bases (DABCO, DBU,²⁸ or triethylamine),²⁹ and phase transfer catalysts (benzyl triethyl ammonium chloride³⁰ or urea),³¹ using ethanol, acetic acid, H₂O, or DMF as solvents. Although each of the reported methods has its own merit, they have some drawbacks, including high temperatures, long reaction time, drastic reaction conditions, difficult work-up, low yields, and environmental problems associated with the chemicals.

4-(Dimethylamino)pyridine (DMAP), a base catalyst, has been used widely in the synthesis of pyran annulated heterocycles via multicomponent reactions (MCRs).³² To the best of our knowledge, there has been no study of the synthesis of 1,4-pyranonaphthoquinone derivatives using DMAP as a catalyst so far. Thus, in continuation of our interests in the synthesis of naphthoquinone derivatives^33-38 and multicomponent reactions,^35-38 herein, we report the synthesis of 1,4-pyranonaphthoquinone derivatives bearing amino and cyano groups via a microwave-assisted three-component reaction between 1,4-naphthoquinone, malononitrile and arylaldehydes using DMAP as an efficient catalyst in ethanol, an environmentally preferable solvent. Besides that, with the aim to discover potent antimicrobial and antifungal agents, the antimicrobial and antifungal activities of the synthetic compounds were evaluated against Gram-positive and Gram-negative bacteri, and fungal strains.

Results and Discussion

In order to assess the efficiency of DMAP as a catalyst, several different catalysts, including NH₄OAc, pyridine, 1,4-diazabicyclo[2.2.2]octane (DABCO), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU), and triethylamine (Et₃N) were tested in the synthesis of 2-amino-5,10-dioxo-4-(p-tolyl)-5,10-dihydro-4H-benzo[g]chromene-3-carbonitrile (12a) (Table 1). All the reactions were carried out on a 1 mmol scale in 3 mL of EtOH in 20 min under microwave at 150 W at an equimolar ratio of reactants 9, 10a, and 11.

Table 1.

Optimization of Catalysts for the Synthesis of Compound 12a.

Entry	Catalyst	Catalytic amount (mol%)	Temp (°C)	Time (min)	Yield, %
1	DMAP	5	80	20	Trace
2	DMAP	10	80	20	15
3	DMAP	20	80	20	71
4	DMAP	20	80	30	60
5	NH₄OAc	20	80	20	50
6	Pyridine	excess	80	20	10
7	DABCO	20	80	20	60
8	DBU	20	80	20	5
9	Et₃N	20	80	20	5

It was worth noting that 20 mol% of DMAP in ethanol furnished the best result in terms of yield (Table 1, entry 3). Based on the optimized condition, various arylaldehydes, 1,4-naphthoquinone, and malononitrile were subjected to the microwave-assisted three-component reaction at 150 W using DMAP in ethanol for 20 min to afford compounds 12 (Figure 2). Compounds 12a-i were furnished in good yield (67-73%) and their structures were fully characterized by IR, ¹H, and ¹³C nuclear magnetic resonance (NMR) spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS).

Figure 2.

Synthesis of compounds 12a–i under microwave irradiation.

The two different reaction pathways from starting materials to final products (12a-i) are described in Figure 3. In path A, DMAP (13) effectively catalyzed the Knoevenagel condensation between arylaldehydes and 2-hydroxy-1,4-naphthoquinone to give 15, which then dehydrated to form intermediate 16. DMAP (13) also catalyzed the generation of a dicyanomethanide ion, which reacted with 16 to furnish intermediate 16. After that, intermediate 16 underwent intramolecular cyclization and [1,3]-hydrogen shift to afford the final product 12. However, the formation of arylidenemalononitriles (21) by Knoevenagel condensation proceeded at first in path B, followed by Michael addition with 2-hydroxy-1,4-naphthoquinone, intramolecular cyclization and [1,3]-hydrogen shift sequence of steps to form 12a-i. Based on the proposed reaction pathways, it is worth pointing out that DMAP (13) as a catalyst has played a significant role in the formation of the title products 12a-i.

Figure 3.

Plausible reaction pathways for the synthesis of 1,4-pyranonaphthoquinone derivatives 12a-i.

The synthetic derivatives 12a-i were then subjected to evaluation for their antimicrobial and antifungal activities using a broth microdilution assay. The compounds were screened against Staphylococcus aureus, Bacillus subtilis, Lactobacillus fermentum (Gram-positive bacteria), Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica (Gram-negative bacteria), and Candida albicans. Unfortunately, these compounds exhibited no activity, with IC₅₀ values ≥100 µM.

Materials and Methods

General Experimental Procedures

IR spectra were recorded on a Perkin Elmer Spectrum Two FT-IR spectrometer in KBr pellets, and ¹H and ¹³C NMR spectra on a Bruker Avance III spectrometer (500 and 125 MHz, respectively) in DMSO-d6. TMS was used as an internal standard. HRMS were recorded on a SCIEX X500 QTOF mass spectrometer in ESI (+) and ESI (−) mode. Melting points were determined using a Büchi B-545 melting point apparatus and are uncorrected. All reagents and solvents were purchased from either Aldrich or Merck, unless noted otherwise. Reactions were performed in an Anton Paar Microwave Synthetic Reactor Monowave 400. TLC was performed using Merck silica gel 60 F254 plates and visualized under UV light at 254 nm. Purification of compounds was carried out using open silica gel column flash chromatography with Merck silica gel 60 (240-400 mesh) as stationary phase.

Synthesis of Compounds 12a-I (see Supplemental Figures S1-S44)

A vial containing a mixture of 2-hydroxy-1,4-naphthoquinone (9) (174 mg, 1.0 mmol), malononitrile (11) (66 mg, 1.0 mmol), arylaldehyde 10a–i (1.0 mmol), and DMAP (0.2 mmol) in EtOH (10 mL) was sealed and placed in a microwave reactor. The vial was subjected to microwave irradiation, programmed at 80 °C and 150 W. After 30 s, the temperature reached a plateau at 80 °C and remained constant. After 20 min, the vial was cooled to room temperature. The crude products were purified by column chromatography using DCM–EtOAc, 20:1, as eluent.

2-Amino-5,10-Dioxo-4-(p-Tolyl)-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12a)

Yield 243 mg (71%), orange solid, mp. 243 °C, lit²⁹ 240 to 242 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.05 (1H, dd, J = 2.0, 7.5 Hz), 7.89 to 7.86 (1H, m), 7.85 to 7.82 (2H, m), 7.26 (2H, s), 7.18 (2H, d, J = 8.0 Hz), 7.10 (2H, d, J = 8.0 Hz), 4.57 (1H, s), 2.24 (3H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.54, 176.87, 158.29, 148.73, 140.62, 136.26, 134.52, 134.11, 131.01, 130.58, 129.11 (2C), 127.55 (2C), 126.04, 125.77, 122.16, 119.32, 57.59, 36.07, 20.57. HRESIMS: Found m/z 341.0919 [M-H]⁻_, calcd. for [C₂₁H₁₃N₂O₃]⁻: 341.0931.

2-Amino-4-(4-Methoxyphenyl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12b)

Yield 240 mg (67%), orange solid, mp. 247 °C, lit²⁹ 247 to 248 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.04 (1H, dd, J = 2.0, 7.5 Hz), 7.90 to 7.86 (1H, m), 7.86 to 7.82 (2H, m), 7.26 (2H, s), 7.22 (2H, d, J = 9.0 Hz), 6.86 (2H, d, J = 8.5 Hz), 4.56 (1H, s), 3.71 (3H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.55, 176.87, 158.25, 148.70, 148.53, 135.61, 134.48, 134.07, 131.00, 130.55, 128.78 (2C), 125.99, 125.74, 122.21, 119.33, 113.90 (2C), 57.65, 55.01, 35.63. HRESIMS: Found m/z 357.0874 [M-H]⁻ calcd. for [C₂₁H₁₃N₂O₄]⁻: 357.0881.

2-Amino-4-(4-Chlorophenyl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12c)

Yield 247 mg (68%), orange solid, mp.256 °C, lit²⁹ 254 to 256 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.03 to 8.00 (1H, m), 7.88 to 7.85 (1H, m), 7.76 to 7.71 (2H, m), 7.26 (2H, d, J = 9.0 Hz), 7.24 (2H, d, J = 8.5 Hz), 7.08 (2H, s), 4.63 (1H, s). ¹³C NMR (DMSO-d₆&CDCl₃, 125 MHz) δ 182.17, 176.66, 158.52, 148.43, 141.70, 134.35, 133.81, 132.17, 130.89, 130.19, 129.26 (2C), 128.34 (2C), 125.98, 125.90, 122.10, 118.85, 57.14, 35.93. HRESIMS: Found m/z 361.0374 [M-H]⁻ calcd. for [C₂₀H₁₀ClN₂O₃]⁻: 361.03854.

2-Amino-4-(4-Bromophenyl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12d)

Yield 285 mg (70%), orange solid, mp. 253 °C, lit²⁹ 253 to 255 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.87 (1H, dd, J = 1.5, 7.0 Hz), 8.72 to 8.65 (3H, m), 8.32 (2H, d, J = 8.5 Hz), 8.17 (2H, s), 8.12 (2H, d, J = 8.5 Hz), 5.46 (1H, s). HRESIMS: Found m/z 404.9858, 406.9865 [M-H]⁻ calcd. for [C₂₀H₁₀BrN₂O₃]⁻: 404.9880, 406.9859.

2-Amino-4-(4-Fluorophenyl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12e)

Yield 253 mg (73%), orange solid, mp. 285 °C, lit²⁹ 286 to 288 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.05 (1H, dd, J = 2.0, 7.5 Hz), 7.89 to 7.85 (1H, m), 7.85 to 7.82 (2H, m), 7.37 (1H, dd, J = 2.0, 8.5 Hz), 7.35 (1H, dd, J = 2.0, 8.5 Hz), 7.31 (2H, s), 7.13 (1H, dd, J = 2.0, 8.5 Hz), 7.11 (1H, dd, J = 2.0, 8.5 Hz), 4.64 (1H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.55, 176.82, 161.17 (d, J = 242.5 Hz), 158.29, 148.90, 139.80 (d, J = 2.5 Hz), 134.50, 134.13, 130.99, 130.62, 129.68 (d, J = 8.75 Hz, 2C), 129.64, 126.03, 125.78, 121.67, 119.21, 115.24 (d, J = 21.25 Hz, 2C), 57.37, 35.79. HRESIMS: Found m/z 345.0670 [M-H]⁻ calcd. for [C₂₀H₁₀FN₂O₃]⁻: 345.0681.

2-Amino-4-(3-Nitrophenyl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12f)

Yield 250 mg (67%), orange solid, mp. 298 °C, lit²⁹ 295 to 297 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.19 (1H, t, J = 2.0 Hz), 8.09 (1H, dd, J = 2.0, 8.0 Hz), 8.05 (1H, dd, J = 1.5, 7.5 Hz),7.88 to 7.81 (4H, m), 7.62 (1H, t, J = 8.0 Hz), 7.44 (2H, s), 4.56 (1H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.59, 176.78, 158.47, 149.37, 147.96, 145.81, 134.78, 134.50, 134.17,130.98, 130.72, 130.08, 126.05, 125.81, 11.48, 122.18, 120.61, 119.02, 56.65. HRESIMS: Found m/z 372.0605 [M-H]⁻ calcd. for [C₂₀H₁₀N₃O₅]⁻: 372.0626.

2-Amino-4-(Naphthalen-1-yl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12g)

Yield 265 mg (70%), orange solid, mp. 250 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.51 (1H, d, J = 8.5 Hz), 8.08 (1H, d, J = 7.5 Hz), 7.94 (1H, d, J = 8.0 Hz), 7.84 (1H, td, J = 2.0, 7.5 Hz), 7.81 to 7.76 (3H, m), 7.65 (1H, t, J = 7.5 Hz), 7.57 (1H, t, J = 7.5 Hz), 7.45 to 7.39 (2H, m), 7.24 (2H, s), 5.61 (1H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.68, 177.00, 158.34, 149.43, 141.24, 134.63, 134.28, 133.35, 131.03, 130.73, 130.64, 128.52, 127.51, 126.35 (2C), 126.19, 125.98, 125.94, 125.83, 123.69, 122.97, 119.38, 58.20, 30.75. HRESIMS: Found m/z 377.0930 [M-H]⁻ calcd. for [C₂₄H₁₃N₂O₃]⁻: 377.09317.

2-Amino-4-(Naphthalen-2-yl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12h)

Yield 268 mg (71%), orange solid, mp. 258 °C. ¹H NMR (DMSO-d₆, 500 MHz): δ 8.08 to 8.05 (1H, m), 7.91 to 7.88 (1H, m), 7.87 to 7.80 (6H, m), 7.50 to 7.46 (3H, m), 7.35 (2H, s), 4.80 (1H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.60, 176.89, 158.28, 148.96, 141.05, 134.48, 134.10, 132.92, 132.13, 131.01, 130.64, 128.23, 127.72, 127.43, 126.21, 126.15, 126.02 (2C), 125.88, 125.75, 121.72, 119.30, 57.42, 36.74. HRESIMS: Found m/z 377.0930 [M-H]⁻ calcd. for [C₂₄H₁₃N₂O₃]⁻: 377.0932.

2-Amino-4-(Benzo[b]Thiophen-3-yl)-5,10-Dioxo-5,10-Dihydro-4H-Benzo[g]Chromene-3-Carbonitrile (12i)

Yield 276 mg (72%), red brown solid, mp. 253 °C. IR (KBr) νmax/cm⁻¹ 3443, 3407, 3318, 3253, 3217, 3191, 3070,2191, 1658, 1629, 1593, 1458, 1423, 1399, 1355, 1339, 1301, 1279, 1242, 1201, 1180, 1093, 1067, 1045, 946, 776, 726, 713. ¹H NMR (DMSO-d₆, 600 MHz): δ 8.08 (1H, dd, J = 2.4, 7.8 Hz), 8.05 (1H, d, J = 8.4 Hz), 7.98 (1H, d, J = 8.4 Hz), 7.90 to 7.82 (3H, m), 7.70 (1H, s), 7.46 (1H, t, J = 7.2 Hz), 7.40 (1H, t, J = 7.8 Hz), 7.33 (2H, s), 5.18 (1H, s). ¹³C NMR (DMSO-d₆, 125 MHz) δ 182.47, 176.87, 158.62, 149.14, 139.82, 139.01, 137.32, 134.51, 134.15, 130.99, 130.67, 126.07, 125.80, 125.45, 124.45, 124.21, 122.93, 121.98, 121.59, 119.43, 56.92, 29.53. HRESIMS: Found m/z 383.0471 [M-H]⁻ calcd. for [C₂₂H₁₁N₂O₃S]⁻: 383.04960.

Antimicrobial and Antifungal Evaluation

The investigated bacterial and fungal strains were obtained from the American Type Culture Collection (ATCC, USA). Compounds 12a-i were evaluated against Staphylococcus aureus (ATCC 13709), Bacillus subtilis (ATCC 6633), Lactobacillus fermentum (N4) (Gram-positive bacteria), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 15442), Salmonella enterica (Gram-negative bacteria), and Candida albicans (ATCC 10231). Bacterial strains were cultured in Mueller-Hinton broth (Merk), and Candida albicans was cultured overnight in Sabouraud dextrose broth. Each well containing 10 μL of compound dissolved in DMSO was diluted together with 190 μL of microorganism suspension (5 × 105 CFU/mL). The negative control wells (without inoculants) and the positive growth control wells (without antimicrobial agents) were reserved in this experiment. The experiments were repeated three times and the results were determined as an average value. Optical density 600 nm (OD600) measurements with a BIOTEK microplate reader spectrophotometer were used to determine the growth/ viability in a liquid sample after 20 h incubation at 37 °C. The results were expressed as % reduction of microorganism viability compared with the positive growth control well.

Conclusions

A synthetic procedure is described for the synthesis of compounds 12a-i via a microwave-assisted three-component reaction in ethanol using DMAP as a base catalyst for the synthesis of a series of 1,4-pyranonaphthoquinones. This report provides an efficient and convenient synthetic method, which features mild reaction conditions, commercially available materials, a very simple and inexpensive workup, and a good yield of products. Moreover, the use of ethanol for these reactions is environmentally friendly and cost-effective.

Supplemental Material

sj-doc-1-npx-10.1177_1934578X211053951 - Supplemental material for 4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives via Microwave-Assisted Sequential Three Component Reaction in Green Solvent

Supplemental material, sj-doc-1-npx-10.1177_1934578X211053951 for 4-(Dimethylamino)pyridine as an Efficient Catalyst for One-Pot Synthesis of 1,4-Pyranonaphthoquinone Derivatives via Microwave-Assisted Sequential Three Component Reaction in Green Solvent by Nguyen Ha Thanh, Hoang Thi Phuong, Le Nhat Thuy Giang, Nguyen Thi Quynh Giang, Nguyen Thi Thu Ha, Dang Thi Tuyet Anh, Vu Duc Cuong, Nguyen Van Tuyen and Phan Van Kiem in Natural Product Communications

Footnotes

Acknowledgments

The authors are indebted to the Institute of Chemistry (codes: NVCC06.01/21-21 and VHH.2021.01) for financial support.

Declaration of Conflicting Interests

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Funding

The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the Institute of Chemistry (grant number NVCC06.01/21-21 and VHH.2021.01).

Ethical Approval

Our institution does not require ethical approval for reporting individual cases or case series.

Statement of Human and Animal Rights

This article does not contain any studies with human or animal subjects.

Statement of Informed Consent

There are no human subjects in this article and informed consent is not applicable.

Trial Registration

Not applicable, because this article does not contain any clinical trials.

ORCID iD

Phan Van Kiem

Supplemental Material

Supplemental material for this article is available online.

References

Liu

Shen

Wang

, et al. Novel modified furanoeremophilane-type sesquiterpenes and benzofuran derivatives from Ligularia veitchiana. Food Chem. 2010;122(1):55-59. doi:10.1016/j.foodchem.2010.01.069

Shang

Salim

Khalil

, et al. Viridicatumtoxins: expanding on a rare tetracycline antibiotic scaffold. J Org Chem. 2015;80(24):12501-12508. doi:10.1021/acs.joc.5b02367

Opatz

Kolshorn

Thines

Anke

. Ascomycones A−C, heptaketide metabolites from an unidentified ascomycete. J Nat Prod. 2008;71(11):1973-1976. doi:10.1021/np800570w

Morita

Sato

Chan

, et al. Samoquasine A, a benzoquinazoline alkaloid from the seeds of Annona squamosa. J Nat Prod. 2000;63(12):1707-1708. doi:10.1021/np000342i

de Aires

Ximenes

ECPA

, et al. β-Lapachone: a naphthoquinone with promising antischistosomal properties in mice. Phytomedicine. 2014;21(3):261-267. doi:10.1016/j.phymed.2013.08.012

Brown

Krishnamoorthy

Mathieson

Thomson

. Naturally occurring quinones. Part XVII. Synthesis of lambertellin. J Chem Soc (C): Organic. 1970;(1):109-110. doi:10.1039/J39700000109

Pialat

Hoffmann

Moulis

Fouraste

Labidalle

. Synthesis and extraction of pentalongin, a naphthoquinoid from Mitracarpus scaber. Nat Prod Lett. 1998;12(1):23-30. doi:10.1080/10575639808048866

Kesteleyn

. Synthesis of two naphthoquinone antibiotics pentalongin and psychorubrin. Synthesis (Mass). 1999;1999(11):1881-1883. doi:10.1055/s-1999-3613

Kesteleyn

De Kimpe

Van Puyvelde

. Total synthesis of two naphthoquinone antibiotics, psychorubrin and pentalongin, and their C(1)-substituted alkyl and aryl derivatives. J Org Chem. 1999;64(4):1173-1179. doi:10.1021/jo9811975

10.

Pereyra

. The diverse mechanisms and anticancer potential of naphthoquinones. Cancer Cell Int. 2019;19:207. doi:10.1186/s12935-019-0925-8

11.

Hayashi

Smith

Lee

. Antitumor agents. 89. Psychorubrin, a new cytotoxic naphthoquinone from Psychotria rubra and its structure-activity relationships. J Med Chem. 1987;30(11):2005-2008. doi:10.1021/jm00394a013

12.

Fabri

Grazul

De Carvalho

, et al. Antitumor, antibiotic and antileishmanial properties of the pyranonaphthoquinone psychorubrin from Mitracarpus frigidus. An Acad Bras Cienc. 2012;84(4):1081-1090. doi:10.1590/S0001-37652012005000064

13.

Guiraud’

Campos-Takaki

RSGM

. Comparison of antibacterial and antifungal activities of lapachol and β-lapachone. Planta Med. 1994;60(4):373-374. doi:10.1055/s-2006-959504

14.

Sperry

Lorenzo-Castrillejo

Brimble

Machín

. Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum. Bioorg Med Chem. 2009;17(20):7131-7137. doi:10.1016/j.bmc.2009.08.064

15.

Nahar

Talukdar

Nath

, et al. Naturally occurring calanolides: occurrence, biosynthesis, and pharmacological properties including therapeutic potential. Molecules. 2020;25(21):4983. doi:10.3390/molecules25214983

16.

Kern

Westbrook

, et al. Plant-derived and semi-synthetic calanolide compounds with in vitro activity against both human immunodeficiency virus type 1 and human cytomegalovirus. Antivir Chem Chemother. 2000;11(1):23-29. doi:10.1177/095632020001100102

17.

Nguyen

Truong

Nguyen

BCQ

, et al. Anti-inflammatory and wound healing activities of calophyllolide isolated from Calophyllum inophyllum Linn. PLoS ONE. 2017;12(10):e0185674. doi:10.1371/journal.pone.0185674

18.

Thomas

Zachariah

Ramani

. 4-Aryl-4H-chromene-3-carbonitrile Derivatives: synthesis and preliminary anti-breast cancer studies. J Heterocycl Chem. 2016;53(6):1778-1782. doi:10.1002/jhet.2483

19.

JYC

Fong

Zhang

, et al. Reversal of multidrug resistance in cancer cells by pyranocoumarins isolated from Radix Peucedani. Eur J Pharmacol. 2003;473(1):9-17. doi:10.1016/S0014-2999(03)01946-0

20.

Rueping

Sugiono

Merino

. Asymmetric organocatalysis: an efficient enantioselective access to benzopyranes and chromenes. Chem Eur J. 2008;14(21):6329-6332. doi:10.1002/chem.200800836

21.

Flavin

Rizzo

Khilevich

, et al. Synthesis, chromatographic resolution, and anti-human immunodeficiency virus activity of (±)-calanolide A and its enantiomers. J Med Chem. 1996;39(6):1303-1313. doi:10.1021/jm950797i

22.

Fadda

Berghot

Amer

Badawy

Bayoumy

. Synthesis and antioxidant and antitumor activity of novel pyridine, chromene, thiophene and thiazole derivatives. Arch Pharm (Weinheim). 2012;345(5):378-385. doi:10.1002/ardp.201100335

23.

El-Agrody

Halawa

Fouda

Al-Dies

AAM

. The anti-proliferative activity of novel 4H-benzo[h]chromenes, 7H–benzo[h]-chromeno[2,3-d]pyrimidines and the structure–activity relationships of the 2-, 3-positions and fused rings at the 2,3-positions. J Saudi Chem Soc. 2017;21(1):82-90. doi:10.1016/j.jscs.2016.03.002

24.

Zghab

Trimeche

Mansour

, et al. Regiospecific synthesis, antibacterial and anticoagulant activities of novel isoxazoline chromene derivatives. Arab J Chem. 2017;10(2):S2651-S2658. doi:10.1016/j.arabjc.2013.10.008

25.

Andrade-Neto

VFD

Goulart

MOF

da Silva Filho

, et al. Antimalarial activity of phenazines from lapachol, β-lapachone and its derivatives against Plasmodium falciparum in vitro and Plasmodium berghei in vivo. Bioorg Med Chem Lett. 2004;14(5):1145-1149. doi:10.1016/j.bmcl.2003.12.069

26.

Pérez-Sacau

Estévez-Braun

Ravelo

ÁG

Gutiérrez Yapu

Giménez Turba

. Antiplasmodial activity of naphthoquinones related to lapachol and β-lapachone. Chem Biodivers. 2005;2(2):264-274. doi:10.1002/cbdv.200590009

27.

Mirjalili

Zamani

Zomorodian

, et al. Synthesis, antifungal activity and docking study of 2-amino-4H-benzochromene-3-carbonitrile derivatives. J Mol Struct. 2016;1116:102-108. doi:10.1016/j.molstruc.2016.03.002

28.

Khurana

Nand

Saluja

. DBU: a highly efficient catalyst for one-pot synthesis of substituted 3,4-dihydropyrano[3,2-c]chromenes, dihydropyrano[4,3-b]pyranes, 2–amino-4H-benzo[h]chromenes and 2-amino-4H-benzo[g]chromenes in aqueous medium. Tetrahedron. 2010;66(30):5637-5641. doi:10.1016/j.tet.2010.05.082

29.

Shaabani

Ghadari

Ghasemi

, et al. Novel one-pot three- and pseudo-five-component reactions: synthesis of functionalized benzo[g]-and dihydropyrano[2,3-g]chromene derivatives. J Comb Chem. 2009;11(6):956-959. doi:10.1021/cc900101w

30.

Yao

. An efficient synthesis of 4H-benzo[g]chromene-5,10-dione derivatives through triethylbenzylammonium chloride catalyzed multicomponent reaction under solvent-free conditions. Chin J Chem. 2009;27(10):1989-1994. doi:10.1002/cjoc.200990334

31.

Brahmachari

Banerjee

. Facile and one-pot access to diverse and densely functionalized 2-amino-3-cyano-4H-pyrans and pyran-annulated heterocyclic scaffolds via an eco-friendly multicomponent reaction at room temperature using urea as a novel organo-catalyst. ACS Sustain Chem Eng. 2014;2(3):411-422. doi:10.1021/sc400312n

32.

Khan

Lal

Ali

Khan

. One-pot three-component reaction for the synthesis of pyran annulated heterocyclic compounds using DMAP as a catalyst. Tetrahedron Lett. 2011;52(41):5327-5332. doi:10.1016/j.tetlet.2011.08.019

33.

Anh

DTT

VTT

Phuong

, et al. Synthesis and anticancer properties of new (dihydro)pyranonaphthoquinones and their epoxy analogs. Bioorg Med Chem Lett. 2015;25(16):3355-3358. doi:10.1016/j.bmcl.2015.05.051

34.

Tuyen

Verniest

Claessens

Kimpe

. Total synthesis of four naturally occurring 2-azaanthraquinone antibiotics, 6–deoxy-8-methylbostrycoidin, 6-deoxybostrycoidin, 7-O-demethyl-6-deoxybostrycoidin and scorpinone. Tetrahedron. 2005;61(9):2295-2300. doi:10.1016/j.tet.2005.01.035

35.

Anh

DTT

Giang

TNT

Giang

NTQ

, et al. Synthesis of novel 3-arylated-2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component domino reaction and evaluation of their cytotoxic activity. Chem Heterocycl Compd. 2021;57(2):137-142. doi:10.1007/s10593-021-02884-9

36.

Giang

NTQ

Gang

LNT

Anh

DTT

, et al. Synthesis of novel potent cytotoxic podophyllotoxin-naphthoquinone compounds via microwave-assited multicomponent domino reactions. Bioorg Med Chem Lett. 2021;37:127841. doi:10.1016/j.bmcl.2021.127841

37.

Thanh

Anh

DTT

Phuong

, et al. A new approach for the synthesis of novel naphthoquinone chalcone hybrid compounds. Tetrahedron. 2021;81:153337. doi:10.1016/j.tetlet.2021.153337

38.

Giang

LNT

Anh

DTT

Phuong

, et al. DMAP-catalyzed efficient and convenient approach for the synthesis of 3,3′-(arylmethylene)bis(2-hydroxynaphthalene-1,4-dione) derivatives. Nat Prod Commun. 2021;16(9):1-7. doi: 10.1177/1934578X211045808

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