Abstract
This paper aims to analyze and perfect the C. nutans-based biodegradable patch for analgesic employing a design of experiment (DoE) by Minitab version 18 program. Fifty-four full factorial design formulation were used to determine three factors and levels. They are made up of various concentration of 2%, 4%, and 6% of sodium alginate (ALG-Na) and Aloe vera juice. The sodium alginate (ALG-Na) and Aloe vera juice play the role of natural film former and terpenes act as permeation enhancers (eugenol, anethole, limonene). The Physicochemical characteristics include weight variation, thickness, surface pH, max stress, % elongation, mucoadhesive time and cost of production. These physicochemical properties were all investigated. The results show that the combination of 6% of sodium alginate (ALG-Na) and anethole produced the total quality (max stress, % elongation, mucoadhesive time, cost of production) (R2 adj > 87.95%, p<0.01). From the Accelerated stability test performed, it was observed that the weight and thickness of the patch were not statistically significantly different (p<0.05). This is a favorable physicochemical property. It is also a cost-effective profile for biodegradable dermal analgesic patches commercial product further.