Abstract
A new compound 1, 3, 6-tri-O-galloyl-2-O-(4- carboxylgalloyl)-β-D-glucopyranose (1), together with six known compounds (2-7) were isolated from EtOAc-soluble extract of fruits of Torreya nucifera. Their structures were elucidated on the basis of detailed spectroscopic and physico-chemical analyses. All the isolates were evaluated for in vitro inhibitory activity against PTP1B, VHR and PP1. Among them, new compound 1 was found to exhibit selective inhibitory activity on PTP1B with IC50 value 8.9 ± 1.4 μM.
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