The dried powdered leaves of Globimetula braunii (Engler) Van Tiegh were effectively extracted by the cold extraction method. Purification of the EtOAc-soluble and MeOH-soluble extracts successfully yielded two lactones namely (R)-6-[(S)-2-hydroxy-4-(4-hydroxyphenyl)butyl]–5,6-dihydropyran-2-one (dodoneine) 1 and (1R,5S,7S)-[2-(4-hydroxyphenyl)ethyl]-2,6-dioxabicyclo[3.3.1]-nonan-3-one (2), together with five flavonoids namely quercetin 3, (+)-catechin 4, quercitrin 5, rutin 6 and avicularin 7. Their structures were established by spectroscopic means, and the absolute configuration of compound 1 was confirmed by X-ray analysis.
HostettmannK, WolfinderJL, RodriguezS, MarstonA. (1996) Strategy in the search for Bioactive Plant Constituents’, Proceeding of the Symposium by International Organization for Chemical Sciences in Development, (IOCD). University of Zimbabwe Publications Limited, 29–34.
2.
ManachC, ScalbertA, MorandC, RémésyC, JiménezL. (2004) Polyphenols: food source and bioavailability. American Journal of Clinical Nutrition, 79, 727–747.
3.
SofoworaA. (1993) Medicinal Plants and Traditional Medicine in Africa, Second Edition, Spectrum Books Limited, Ibadan, 134–156.
4.
BurkillHM. (2003) The useful plants of West Tropical Africa, Second Edition, Vol. 3, 548–857.
5.
OluweleO, OsungunnaMO, AbimbolaY. (2013) Phytochemical and antimicrobial screening of Globimetula oreophila (Spreng) Balle. International Journal of Green Pharmacy, 7, 127–130.
6.
OlagunjuJA, IsmailFI, GbileZO. (1999) The hypoglycaemic property of Normal saline leaf of Globimetula braunii in alloxanised diabetic albino rats. Biomedical Letters, 60, 83–89.
7.
AliyuMM, MusaAI, KamalMJ, MohammedMG. (2014) Phytochemical screening and anticonvulsant studies of ethyl acetate fraction of Globimetula braunii on laboratory animals. Asian Pacific Journal of Tropical Biomedicine, 4, 285–289.
8.
OuedraogoM, CarreyreH, VandebrouckC, BescondJ, RaymondG, GuissouIP, CognardC, BecqF, PotreauD, CoussinA, MarrotJ, CoustardJM. (2007) Structure elucidation of a dihydropyranone from Tapinanthus dodoneifolius. Journal of Natural Products, 70, 2006–2009.
TachakittirungrodS, IkegamiF, OkonogiS. (2007) Antioxidant active principles isolated from Psidium guajava grown in Thailand, Scientia Pharmaceutica, 75, 179–193.
12.
LinJ, LinY. (1999) Flavonoids from the leaves of Loranthus koi (Chao) Kiu. Journal of Food and Drug Analysis, 7, 185–190.
13.
HasanMS, AhmedMI, MondalS, UddinSJ, MasudMM, SadhuSK, IshibashiM. (2006) Antioxidant, antinociceptive activity and general toxicity study of Dendrophthoe falcata and isolation of quercitrin as the major component. Oriental Pharmacy and Experimental Medicine, 6, 355–360.
14.
SintayehuB, AsresK, RaghavendraY. (2012) Radical scavenging activities of the leaf extracts and a flavonoid glycoside isolated from Cineraria abyssinica Sch. Bip. Exa. Rich, Journal of Applied Pharmaceutical Science, 02, 44–49.
15.
LuY, FooLY. (1997) Identification and quantification of major polyphenols in apple pomace. Food Chemistry, 59, 187–194.
16.
AlvesRJ, BarrosOSdR, KatoL, MartinsFT, de OliveiraCMA. (2013) Synthesis and absolute stereochemistry of the bicyclic goniofupyranone core. Journal of Molecular Structure, 1035, 448–449.
17.
AndrianaivoravelonaJO, SahpazS, TerreauxC, HostettmannK, Stoeckli-EvansH, RasolondramanitraJ. (1999) Two 6-substituted 5,6-dihydro-a-pyrones from Ravensara anisata. Phytochemistry, 52, 265–269.
18.
DeschampsJR, GeorgeC, Flippen-AndersonJL, SpencerG. (2001) A new crytocarya lactone. Acta Crystallographica, E57, o648–o649.
19.
FangXP, AndersonJE, ChangCJ, McLaughlinJL, FanwickPE. (1991) Two new styryl lactones, 9-deoxygoniopypyrone and 7-epi-goniofufurone, from Goniothalamus giganteus. Journal of Natural Products, 54, 1034–1043.
20.
LanYH, ChangFR, LiawCC, WuCC, ChiangMY, WuYC. (2005) Digoniodiol, deoxygoniopypyrone A and goniofupyrone A: Three new styryllactones from Goniothalamus amuyon. Planta Medica, 71, 153–159.
21.
SaidIM, OthmanAH, NgSW. (1995) Crystal structure of 6-(7,8-dihydro-7,8-dihydroxystyryl)-5,6-dihydro-2-pyrone (goniodiol), Malaysian Journal of Science, Series B: Physical & Earth Sciences, 1995, 16, 81–83.
MazaH, MkoungaP, FenkamSL, SadoSK, IshikawaH, NishinoH, NkengfackEA. (2017) Triterpenoids from seeds of Tapinanthus bangwensis. Phytochemistry Letters, 19, 23–29.
24.
LiuQY, WangF, ZhangL, XieJM, LiP, ZhangYH. (2015) A hydroxylated lupeol-based triterpenoid ester isolated from the Scurrula parasitica parasitic on Nerium indicum. Helvetica Chimica Acta, 98, 627–632.
25.
TsaiTH, LiuYC, LinLC. (2010) Flavonoids from Taxillus theifer. Journal of Food and Drug Analysis. 18, 256–262.
26.
OhashiK, WinarnoH, MukaiM, InoueM, PranaMS, SimanjuntakP, ShibuyaH. (2003) Indonesian Medicinal Plants. XXV. Cancer cell invasion inhibitory effects of chemical constituents in the parasitic plant Scurrula atropurpurea (Loranthaceae). Chemical and Pharmaceutical Bulletin, 51, 343–345.
27.
SoberónJR, SgarigliaMA, SampietroDA, QuirogaEN, VattuoneMA. (2010) Free radical scavenging activities and inhibition of inflammatory enzymes of phenolics isolated from Tripodanthus acutifolius. Journal of Ethnopharmacology, 130, 329–333.
28.
GrazianoMN, WidmerGA, JulianiR, CoussioJD. (1967) Flavonoids from the Argentine Mistletoe Psittacanthus cuneifolius. Phytochemistry, 6, 1709–1711.
29.
FukunagaT, NishiyaK, KajikawaI, TakeyaK, ItokawaH. (1989) Studies on the constituents of Japanese Mistletoes from different host trees, and their antimicrobial and hypotensive properties. Chemical and Pharmaceutical Bulletin, 37, 1543–1546.
30.
KonishiT, NishioT, KiyosawaS, FujiwaraY, KonoshimaT. (1996) The constituents of Taxillus kaempferi and the host Pinus thunbergii. I. catechins and flavones of Taxillus kaempferi. Yakugaku Zasshi, 116, 148–157.
31.
HopeH. (1994) X-Ray crystallography: A fast, first-resort analytical tool. Progress in Inorganic Chemistry, 41, 1–19.
32.
SengeMO. (2000) A conformational Study of 5,10,15,20-tetraaalkyl-22H+,24H+-porphyrindiium salts (dication salts). Zeitschrift für Naturforschung, 55b, 336–344.
33.
Bruker (2014) SAINT, APEX3 and SADABS. Bruker AXS Inc., Madison, Wisconsin, USA.
34.
DolomanovOV, BourhisLJ, GildeaRJ, HowardJAK, PuschmannH. (2009) OLEX2: A complete structure solution refinement and analysis program. Journal of Applied Crystallography, 42, 339–341.
