Abstract
Naringenin (NG) is a flavanone abundant in grapefruit and other citrus fruits that presents several pharmacological effects, such as antioxidant, anti-inflammatory, analgesic, among others. We investigated the antinociception of systemic administration of naringenin (NG) and some of the mechanisms of action underlying its effect. Intraperitoneal administration of NG (10 mg/kg) inhibited the mechanical allodynia induced by partial sciatic nerve ligation (PSNL) and carrageenan in 65 ± 4 and 43 ± 9% (2 h), respectively. NG also reduced the writhes number (30 mg/kg: 90 ± 9%) and the nociceptive response of formalin (100 mg/kg: 75 ± 12%, inflammatory phase), bradykinin (30 mg/kg: 79 ± 6%) and prostaglandin E2 (100 mg/kg: 98 ± 1%). Besides, NG reduced the glutamate-induced nociception with ID50 value of 66 mg/kg, effect that was reversed by naloxone. NG, at antinociceptive doses, did not affect the locomotor activity. Our findings demonstrated that systemic NG exerts anti-allodynic activity in neuropathic pain model and antinociceptive effect in several chemical and inflammatory models of nociception, with participation of glutamatergic and opioid system.