The isolation is reported of artemisinin (qinghaosu), a drug remarkably effective against malaria, from the aerial parts of Artemisia annua L. (sweet wormwood) at the Department of Chemistry, University of Belgrade (now Faculty of Chemistry), Serbia by the end of 1970, almost two years before the isolation of the same compound in China.
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2.
YouyouT. (2011) The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine. Nature Medicine, 17, 1217–1220. doi:10.1038/nm.2471/Published online 11 October 2011.
3.
(a) StefanovićM., JokićA., BehbudA., JeremićD. (1972) New type of sesquiterpene lactone isolated from Artemisia annua L.- arteannuin epoxide.8th International Symposium on the Chemistry of Natural Products, New Delhi, Abstracts C-56, 221; (b) Jeremić D, Jokić A, Behbud A, Stefanović M. (1972) New type of sesquiterpene lactones isolated from Artemisia annua L.- ozonide of dihydroarteannuin. 8thInternational Symposium on the Chemistry of Natural Products, New Delhi, Abstract C-57, 222.
4.
JeremićD., JokićA., BehbudA., StefanovićM. (1973) A new type of sesquiterpene lactone isolated from Artemisia annua L. arteannuin B. Tetrahedron Letters, 3039–3042.
5.
BehbudA. (1971) Chemical investigation of some domestic Artemisia. PhD Thesis (in Serbian), Faculty of Science, University of Belgrade.
6.
HerzW., HögenauerG. (1961) Isolation and structure of coronopilin, a new sesquiterpene lactone. The Journal of Organic Chemistry, 26, 5011–5013.
7.
Cooperative Group on Qinghaosu Structural Research. (1977) A new type of sesquiterpene lactone—Qinghaosu. Ke Xue Tong Bao (Engl. Chinese Science Bulletin), 22, 142.
8.
StefanovićM., SolujićS., JeremićD., JokićA., MiljkovićD., VelimirovićS. (1977) Chemical transformations of arteannuin B – cadinane sesquiterpenic lactone – isolated from Artemisia annua L. Bulletin de la Société Chimique Beograd, 42, 227–236.
9.
BrownG.D. (2010) The biosynthesis of artemisinin (qinghaosu) and the phytochemistry of Artemisia annua L. (Qinghao). Molecules, 15, 7603–7698.
10.
UskokovićM.R., WilliamsT.H., BlountJ.F. (1974) The structure and absolute configuration of arteannuin B. Helvetica Chimica Acta, 57, 600–602.
11.
LeppardD.G., ReyA., DreidingA., GriebR. (1974) The structure of arteannuin B and its acid hydrolysis product. Helvetica Chimica Acta, 57, 602–615.
12.
BhakuniR.S., JainD.C., SharmaR.P., KumarS. (2001) Secondary metabolites of Artemisia annua and their biological activity. Current Science, 80, 35–48.
13.
ZhangC., GongM-X, QiuF., LiJ., Man-WangM-Y. (2016) Effects of arteannuin B, arteannuic acid and scopoletin on pharmacokinetics of artemisinin in mice. Asian Pacific Journal of Tropical Medicine, 9, 677–681.
14.
SyL-K, BrownG.D. (2001) Deoxyarteannuin B, dihydro-deoxyarteannuin B and trans-5-hydroxy-2-isopropenyl-5-methylhex-3-en-1-ol from Artemisia annua. Phytochemistry, 58, 1159–1166.
15.
RothR.J., ActonN. (1987) Epideoxyarteannuin B isolated from Artemisia annua. Planta Medica, 53, 576.
16.
BrownG.D. (1992) Two new compounds from Artemisia annua. Journal of Natural Products, 55, 1756–1760.
17.
DjermanovićM., JokićA., MladenovićS., StefanovićM. (1975) Quercetagetin 6,7,3′,4′-tetramethyl ether: a new flavonol from Artemisia annua. Phytochemistry, 14, 1873.
18.
(a) YouyouT., MuyunN., YurongZ., LannaL., ShulianC., MuqunZ., XiuzhenW., ZhengJ., XiaotianL. (1982) Studies on the constituents of Artemisia annua. Planta Medica, 44, 143–145, and references therein; (b) Misra LN, Ahmad A, Thakur RS, Jakupovic J. (1993) Bisnor-cadinanes from Artemisia annua and definitive 13C NMR assignments of β-arteether. Phytochemistry, 33, 1461–1464.
19.
Jing-MingL., Mu-YunN., Ju-FenF., You-YouT., Zhao-HuaW., Yu-LinW., Wei-ShanZ. (1979) Structure and reaction of arteannuin. Hua Xue Xue Bao (Acta Chemica Sinica), 37, 129–143.
20.
Qinghaosu Antimalaria Coordinating Research Group. (1979) Antimalarial studies of qinghaosu. Chinese Medical Journal (English edition), 92, 811–816.
21.
Qinghaosu Res. Group, Inst. Biophysics, Academia Sinica (1980) Crystal structure and absolute configuration of qinghaosu. Scientia Sinica (English Edition), 23, 380–396.
